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Neuropathic Pain clinical trials

View clinical trials related to Neuropathic Pain.

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NCT ID: NCT06330181 Recruiting - Clinical trials for Spinal Cord Injuries

Virtual Walking Therapy for Neuropathic Pain Following Incomplete Spinal Cord Injury

Start date: March 2024
Phase: N/A
Study type: Interventional

The purpose of this study is to determine if playing a virtual reality walking game can help improve neuropathic pain in adults with incomplete spinal cord injury.

NCT ID: NCT06324123 Recruiting - Neuropathic Pain Clinical Trials

Observational Study Aimed at Evaluating the Trend of Neuropathic Pain

NEURATIL
Start date: June 9, 2023
Phase:
Study type: Observational

The present study aims to evaluate the trend of neuropathic pain in patients treated with Peacetil for a period of two months. Neuropathic pain will me assessed through the Numeric Rating Scale (NRS) questionnaire score.

NCT ID: NCT06297915 Completed - Neuropathic Pain Clinical Trials

Infusion Treatments of Chronic Peripheral Neuropathic Pain

Start date: May 17, 2022
Phase:
Study type: Observational

This study aimed to evaluate and compare the efficacy of ketamine and lidocaine infusion in patients with chronic peripheral neuropathic pain. Patients who received intravenous ketamine infusion and the other patient group who received intravenous lidocaine infusion were evaluated in the study. Pain scores and quality of life were assessed with scales before treatment at two weeks, two months, and six months after treatment.

NCT ID: NCT06292962 Active, not recruiting - Diabetes Mellitus Clinical Trials

Evaluating the Impact of Vagus Nerve Stimulation on Diabetic Peripheral Neuropathic Pain

VNSDPN
Start date: October 1, 2023
Phase: N/A
Study type: Interventional

The purpose of the study is to investigate the effects of non-invasive invasive vagal nerve stimulation on diabetic peripheral neuropathic pain in people with diabetes.

NCT ID: NCT06290661 Recruiting - Neuropathic Pain Clinical Trials

Clinical Trial of the Safety and Efficacy of Peripheral Nerve Stimulation in the Treatment of Postherpetic Neuralgia.

Start date: February 9, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to evaluate safety and efficacy of percutaneous peripheral nerve stimulation in patients with postherpetic neuralgia. The main questions it aims to answer are: 1. The efficacy of percutaneous peripheral nerve stimulation in patients with postherpetic neuralgia 2. The safety of percutaneous peripheral nerve stimulation in patients with postherpetic neuralgia Participants are going to undergo procedure that implant peripheral nerve stimulation electrode produced by Jiangsu CED Medtech Co., Ltd. Then the subjects, whose VAS scores decrease more 30% than baseline level, are classified into two groups randomly. One of the group receiving active stimulation called trial group and another receiving placebo stimulation called control group. All subjects are required to make their own subjects' pain diary to record VSA score before and after implantation until at the end of follow-up. Also, participants are asked to report use of analgesic medications, number of awakenings and adverse events. Researchers will compare pain scores between the two groups to see if peripheral nerve stimulation is effective to patients with postherpetic neuralgia.

NCT ID: NCT06284694 Not yet recruiting - Neuropathic Pain Clinical Trials

Treatment of Neuropathic Pain Following Spinal Cord Injury - a rTMS Approach

Start date: May 1, 2024
Phase: N/A
Study type: Interventional

This study aims to determine if repetitive transcranial magnetic stimulation (rTMS) can improve pain symptomology in adults with neuropathic pain (NP) following a spinal cord injury (SCI).

NCT ID: NCT06270940 Not yet recruiting - Neuropathic Pain Clinical Trials

Prospective Study Upon Pulsed Radiofrequency Therapy on Peripheral Nerves Monitoring Pain, Quality of Life, Patient Satisfaction and Efficacy

PURPOSE
Start date: March 1, 2024
Phase:
Study type: Observational [Patient Registry]

Neuropathic pain is a chronic condition caused by damage to the somatosensory nervous system. The pain associated with neuropathic pain is often severe and debilitating, and can significantly interfere with the quality of life and daily functioning of affected patients. Current pharmacologic treatments, such as antidepressants, antiepileptics, and opioids, can offer only partial relief for 40-60% of patients, and are often accompanied by severe side effects. This has led to increasing interest in non-pharmacologic management options for neuropathic pain. One such promising treatment option is pulsed radiofrequency (PRF) treatment applied to the affected peripheral nerve in conjunction with local anesthetic and/or corticosteroid medication. Several studies, including case reports, retrospective studies, and small randomized controlled trials, have shown that PRF treatment to the affected peripheral nerve can be beneficial and effective for managing chronic peripheral neuropathic pain. Several peripheral neuralgias, such as thoracic postherpetic neuralgia, occipital neuralgia, pudendal neuralgia, meralgia paresthetica, painful shoulder, post-thoracotomy syndrome, and carpal tunnel syndrome, have been successfully treated with PRF. PRF treatment has garnered significant interest among ultrasound-skilled pain physicians because of its superior, safe, and non-destructive percutaneous approach to peripheral nerves, visualized by today's excellent visual ultrasound guidance. Our academic pain center performs approximately more than 1000 ultrasound-guided peripheral nerve blocks per year on a wide range of peripheral nerves. Moderate evidence for treating peripheral nerves with PRF treatment is available; however, PRF treatment settings such as voltage, number of cycles, and treatment duration vary, and it is not clear which setting contributes most substantially to pain reduction results. The aim of this prospective longitudinal observational data collection is to evaluate the efficacy of PRF treatment applied to peripheral nerves, to observe the clinical course of chronic peripheral neuropathic pain under conditions of routine clinical practice, and to link these observations with clinical outcomes.

NCT ID: NCT06252116 Recruiting - Neuropathic Pain Clinical Trials

Study of Analgesic Action of Pregabalin, Duloxetine and Tramadol in Patients With Different Neuropathic Pain Phenotypes

Start date: March 5, 2018
Phase:
Study type: Observational [Patient Registry]

Chronic pain is the most frequent cause from which millions of patients suffer worldwide, which makes them unable to work but also greatly affects their quality of life. Chronic pain is a condition in itself. Neuropathic pain is a consequence of damage or disease of the peripheral or central nervous system and presents a heterogeneous clinical profile. A large number of pharmaceutical and non-pharmacological agents, as well as various complementary therapies, have been used in the treatment of neuropathic pain. However, their effectiveness is considered moderate and limited and is under investigation because a significant proportion of patients do not respond satisfactorily to treatment. Purpose: The purpose of the study is to investigate the effectiveness of analgesics in the different phenotypes of neuropathic pain.

NCT ID: NCT06250491 Recruiting - Fibromyalgia Clinical Trials

Deep rTMS (H-coil) for Neuropathic Pain or Fibromyalgia

H-FINEP
Start date: January 30, 2024
Phase: N/A
Study type: Interventional

This study will investigate the efficacy and safety of "deep" rTMS on neuropathic pain or fibromyalgia. It will be randomized and sham controlled and will last 3 months. Patients will be randomized to receive acctive rTMS or sham rTMS and will receive repeated rTMS sessions (5 daily sessions then one session per week then every 2 to 3 weeks for up to 10 weeks).

NCT ID: NCT06249724 Not yet recruiting - Chronic Pain Clinical Trials

Noninvasive Modulation of Chronic Neuropathic Pain

Start date: April 1, 2024
Phase: Phase 1/Phase 2
Study type: Interventional

This study will apply low-intensity transcranial focused ultrasound to dorsal root ganglia in patients with chronic neuropathic pain. The target will be validated using magnetic resonance imaging. The stimulation will first be delivered using a range of stimulation parameters during psychophysical and physiological monitoring. A well-tolerated stimulation protocol will be selected for subsequent testing in a blinded randomized sham-controlled cross-over trial. The level of pain will be evaluated using the Numerical Rating Scale (NSR-11) and the Patient-Reported Outcomes Measurement Information System (PROMIS) numerical rating scales of pain.