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Nausea clinical trials

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NCT ID: NCT03137121 Completed - Advanced Cancer Clinical Trials

Olanzapine for the Treatment of Chronic Nausea and/or Vomiting in Advanced Cancer Patients

Start date: July 12, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to evaluate the use of olanzapine for the treatment of cancer patients with chronic nausea and/or vomiting unrelated to chemotherapy or radiation in a randomized placebo-controlled pilot trial.

NCT ID: NCT03130218 Completed - Clinical trials for Bariatric Surgery Candidate

Aromatherapy in Management of Postoperative Nausea in Post-Bariatric Surgery Patients

Start date: June 8, 2017
Phase: N/A
Study type: Interventional

Determine the effectiveness of peppermint oil aromatherapy in relieving post-operative nausea in the bariatric surgery patient population.

NCT ID: NCT03125811 Completed - Nausea Clinical Trials

Value of Ondansetron Medication vs Inhaled Isopropyl Therapy in the Emergency Department (VOMIITED)

VOMIITED
Start date: July 17, 2017
Phase: Early Phase 1
Study type: Interventional

This study will compare two different ways to relieve nausea and vomiting in the Emergency Department. The usual treatment for nausea/vomiting is a drug called Zofran, but new studies have suggested that smelling alcohol pads can also help to relieve nausea and vomiting.

NCT ID: NCT03100669 Completed - Postoperative Pain Clinical Trials

Implementing a Postoperative MIRP (Minimally Invasive Repair of Pectus) Program Via Tele-monitoring

Start date: May 1, 2017
Phase:
Study type: Observational [Patient Registry]

MIRP (Minimally Invasive Repair of Pectus) as surgical correction of pectus excavatum or carinatum is performed to achieve physiological, cosmetic, and psychological benefits for the patient. Surgery is often associated with severe postoperative pain. In this study the researchers want to registrate pain, sleep, nausea/vomiting, and daily activities in short and long term follow up.

NCT ID: NCT03076411 Completed - Nausea Clinical Trials

Pepsin in Patients With Functional Dyspepsia

Start date: January 11, 2012
Phase: N/A
Study type: Observational

This non-interventional, observational study investigates the course of symptoms in patients with functional dyspepsia under treatment with a fixed combination of pepsin and amino acid hydrochloride over a period of approximately 6 weeks. The change of the Gastrointestinal Symptom Score (GIS©) was the primary parameter for the assessment of efficacy and was performed at baseline, after 3 and 6 weeks of treatment respectively. Safety measures included recording of AEs and physical examination as well as measurement of vital signs. The aim was to observe 100 patients during the course of this non-interventional study.

NCT ID: NCT03060746 Completed - Weight Loss Clinical Trials

Helicobacter Pylori Sample Collection Protocol Pre Therapy Subjects

Start date: February 14, 2017
Phase:
Study type: Observational

The primary objective is to obtain stool samples from pre-therapy subjects already undergoing evaluation for an H. pylori infection by upper esophagogastroduodenoscopy (EGD) and gastric biopsy.

NCT ID: NCT03060733 Completed - Weight Loss Clinical Trials

Helicobacter Pylori Sample Collection Protocol Post Therapy Subjects

Start date: February 14, 2017
Phase:
Study type: Observational

The primary objective is to obtain stool samples from post-therapy subjects already undergoing evaluation for an H. pylori infection by upper esophagogastroduodenoscopy (EGD) and gastric biopsy.

NCT ID: NCT03045133 Completed - Pain, Postoperative Clinical Trials

QUALITY OF RECOVERY AFTER INTRAOPERATIVE MORPHINE OR METHADONE

Start date: June 20, 2016
Phase: Phase 4
Study type: Interventional

Introduction. Despite the advantages associated with the use of remifentanil during total intravenous anesthesia (TIVA), it has been observed a frequent difficulty in the control of postoperative pain due to the risk of developing hyperalgesia and acute tolerance associated with the administration of this opioid. There is evidence that NMDA receptors are involved in the development of these changes. Methadone is an opioid that exhibits analgesic potency similar to that of morphine but has NMDA antagonist activity and longer duration of action as additional features. The objective of the study was to evaluate the quality of recovery (QoR40) of patients undergoing TIVA for laparoscopic cholecystectomy and who received morphine or methadone to control postoperative pain. Methods. Patients aged 18 to 65 years, physical status ASA I and II, submitted to total venous anesthesia (propofol and remifentanil) for laparoscopic cholecystectomy and eligible to participate in this prospective and randomized clinical study will be evaluated. After induction of anesthesia, patients will receive a solution containing 0.1 mg.kg-1 morphine (MF group) or 0.1 mg.kg-1 methadone (MT group). Data on the presence of pain, nausea, vomiting, tremor, drowsiness, presence of SpO2 <92%, even with O2 face mask (5 L.min-1) and length of stay will be recorded at PACU. The pain will be evaluated every 15 minutes on a verbal numerical scale (ENV) from 0 to 10. E.v. morphine 0.1 mg.kg-1 (MF group) or methadone 0.1 mg.kg-1 (MT group) will be administered every 15 minutes to obtain the score below 3. After discharge from the PACU, all patients will receive intravenous ketoprofen every 12 hours and dipyrone every 6 hours. For cases where the patient considers the analgesic regimen insufficient, tramadol (100 mg) will be administered intravenously at 8-hour intervals. The consumption of analgesics, the intensity of pain, the occurrence of nausea, vomiting and other complications in the ward will be recorded. The application of the questionnaire (QoR40) will be performed in the ward the morning after the surgery by a medical student.

NCT ID: NCT03040726 Completed - Nausea Clinical Trials

Netupitant and Palonosetron Hydrochloride in Preventing Chronic Nausea and Vomiting in Patients With Cancer

Start date: May 3, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

This randomized phase II/III trial studies how well netupitant and palonosetron hydrochloride works in preventing chronic nausea and vomiting in patients with cancer. Netupitant and palonosetron hydrochloride may reduce nausea and vomiting.

NCT ID: NCT03035942 Completed - Pruritus Clinical Trials

Quality of Recovery After Dexamethasone, Ondansetron or Placebo Intrathecal Morphine Administration

Start date: January 2, 2017
Phase: Phase 4
Study type: Interventional

The aim of this study is to evaluate not only the occurrence of side effects, but the quality of the recovery (QoR-40 Questionnaire) of patients submitted to spinal anesthesia with administration of low doses (0.1 mg) of intrathecal morphine for the surgical treatment of fractures in one of the lower limbs and who will receive prophylactic ondansetron (4mg), dexamethasone (8mg) or placebo.