Clinical Trials Logo

Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05664269
Other study ID # NL81203.068.22 / METC 22-031
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date March 20, 2023
Est. completion date August 1, 2024

Study information

Verified date December 2022
Source Maastricht University Medical Center
Contact Wesley Hermans, MSc
Phone 0031433881810
Email w.hermans@maastrichtuniversity.nl
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Muscle tissue consists of proteins. These proteins are built up of small building blocks: amino acids. By consuming enough protein in our diet, we make sure that the body is provided with enough amino acids to facilitate muscle protein building. Also after exercise is protein intake important as it contributes to the recovery process. Providing the growing world population with sufficient animal-derived protein is a challenge. Plant proteins can be produced on a more sustainable commercial scale than conventional animal-derived proteins and therefore, can contribute to feeding our future population. Canola protein is a protein that is derived from rapeseed. The composition of canola seems to be comparable to that of other high-quality animal-based protein sources. But there is no data yet on the effect of canola protein ingestion on muscle growth. Additionally, most research on the effect of protein intake and muscle growth/recovery has been performed in males and we need more insight into the effect in females. The goal of this study is to investigate whether the ingestion of canola protein can stimulate muscle growth just as good as whey protein after a strength exercise session in females. Primary objective: To assess the impact of 20g canola or 20g whey protein vs placebo ingestion on acute 5-hour postprandial muscle protein synthesis rates during recovery from lower-body resistance-type exercise in vivo in young females. Secondary objective: To assess the impact of 20g canola protein vs 20g whey protein ingestion on acute 5-hour postprandial muscle protein synthesis rates during recovery from lower-body resistance-type exercise in vivo in young females. Tertiary objectives: Compare signaling pathways and. postprandial 5-hour plasma glucose, insulin, and amino acid concentrations, (including area under the curve, peak concentrations, and time to peak) following canola protein, whey protein, and placebo ingestion during recovery from lower-body resistance-type exercise in young females. Hypothesis: it is hypothesized that acute 5-hour postprandial muscle protein synthesis rates will be not different following 20g canola protein and 20g whey protein ingestion and higher compared to placebo during lower-body post-exercise recovery in healthy young females.


Description:

Read more »
Read more »

Study Design


Related Conditions & MeSH terms


Intervention

Dietary Supplement:
drink ingestion
drink ingestion of a vanilla-flavoured beverage from a non-transparent shaker
Behavioral:
resistance-type exercise
Lower body resistance-type exercise on the supine leg press and seated knee extension machine. Both machines 4 sets at 80% 1RM for 8-10 reps.

Locations

Country Name City State
Netherlands Maastricht University Medical Centre+ Maastricht Limburg

Sponsors (2)

Lead Sponsor Collaborator
Maastricht University Medical Center DSM Food Specialties

Country where clinical trial is conducted

Netherlands, 

Outcome

Type Measure Description Time frame Safety issue
Other Age in years Age in years reported by participants baseline at screening
Other bodymass in kg scale baseline at screening
Other Height in m stadiometer baseline at screening
Other BMI in kg/m^2 calculated from height and body mass baseline at screening
Other Whole body lean mass in kg dexa baseline at screening
Other Appendicular lean mass in kg dexa baseline at screening
Other bodyfat% dexa baseline at screening
Other Dietary macronutrient intake assessed by written dietary intake records 2 days prior to experimental trial day
Other Maximal leg strength 1-Repetition-maximum assessed on leg press and knee extension baseline at screening
Other drink palatability Assessed by a visual analogue scale after drink ingestion On experimental trial day directly after drink ingestion
Primary Postprandial muscle protein fractional synthesis rate Muscle protein synthesis rates are calculated using L-ring-13C6-phenylalanine tracer and provided as 1 integrated value over the specified timeframe using plasma as precursor. 0-5 hours
Secondary 'basal' muscle protein fractional synthesis rate Muscle protein synthesis rates are calculated using L-ring-13C6-phenylalanine tracer and provided as 1 integrated value over the specified timeframe using plasma as precursor. -3 - 0 hours
Secondary Plasma glucose concentrations Plasma glucose concentrations 0-5 hours
Secondary Plasma insulin concentrations Plasma insulin concentrations 0-5 hours
Secondary Plasma amino acids concentrations Plasma amino acids concentrations 0-5 hours
See also
  Status Clinical Trial Phase
Completed NCT05386771 - Effects of Whey and Collagen Protein Blend on Protein Synthesis Rates N/A
Recruiting NCT05711095 - The Anabolic Properties of Fortified Plant-based Protein in Older People N/A
Withdrawn NCT00653679 - Exercise and Muscle Protein Signalling N/A
Completed NCT03372928 - Essential Amino Acids and Protein Kinetics During Caloric Deprivation N/A
Completed NCT04121689 - Time Course of Postprandial Protein Metabolism N/A
Completed NCT03303729 - Influence of Carbohydrate on Amino Acid Absorption From Dietary Protein (ICADP) N/A
Not yet recruiting NCT02732353 - Absorption and Muscle-stimulating Effect of Hydrolyzed and Minced Beef N/A
Completed NCT04302038 - The Effects Potato Protein on Rates of Myofibrillar Muscle Protein Synthesis in Young Women N/A
Completed NCT03994198 - Effect of Protein Quality During Overreaching in Trained Cyclists N/A
Active, not recruiting NCT05347667 - Menstrual Cycle Phase Muscle Protein Synthesis N/A
Completed NCT04894747 - Mycoprotein and Pea Protein Blend and Muscle Protein Synthetic Response N/A
Completed NCT05353595 - The Effect of Mealworm Protein Ingestion on Muscle Protein Synthesis After Running Exercise in Humans N/A
Completed NCT05151887 - The Impact of a Whole-food Animal-based Versus Plant-based Protein Rich Meal on Muscle Protein Synthesis N/A
Not yet recruiting NCT06435637 - Effects of Ingesting Multiple Boluses of Collagen on Muscle & Skin Connective Protein Synthesis in Vivo in Humans N/A
Recruiting NCT04232254 - Defining Beef and Meal Frequency as Key Components of a Healthy Eating Pattern for Muscle Health and Wellbeing N/A
Completed NCT04981652 - The Effect of Whole Milk to Improve Muscle Health in Older Women N/A
Recruiting NCT05876299 - The Anabolic Properties of a Lipid-rich Pork Matrix N/A
Completed NCT02282566 - Effect of Protein-nutrition Beverages on Muscle Protein Synthesis in Women N/A
Completed NCT01885429 - Effect of Supplementing a Mixed Macronutrient Beverage With Graded Doses of Leucine on Myofibrillar Protein Synthesis N/A
Completed NCT05178732 - The Effect of Menstrual Cycle Phase and a Protein-polyphenol Drink on Muscle Protein Synthesis N/A