Effect of Protein Quality During Overreaching in Trained Cyclists

Status Completed

Clinical Trial Summary

Athletes frequently undertake periods of intensified training commonly referred to as "overreaching." These training periods acutely decrease performance, with the expectation that performance will rebound and improve after a short recovery. Yet, overreaching does not always improve performance and may be a precursor to overtraining syndrome, a long-term decrement in performance. A nutritional intervention focused on the adoption of 'best practices' for protein feeding (optimal timing, dose, and quality) could help reduce the stress of overreaching, reduce the likelihood of developing overtraining syndrome, and augment adaptations to intensified exercise. While the nutrition study is our main interest, the investigators first want to validate the measurement of exercise performance. Accordingly, this project consists of two related studies: (1) the assessment of short time trials for reliability and validity; and (2) the assessment of optimal protein feeding to decrease the stress of overreaching and improve outcomes following training.

Clinical Trial Description

Endurance-trained athletes frequently undergo periods of overreaching (increased training loads) to improve performance. In study 1, the investigators will determine whether 4-min and 20-min time trials are repeatable and whether they (individually or collectively) relate to 1-hour time trial performance. For Study 2, the investigators propose that proper nutrition (with a focus on the dose, timing, and quality of protein) can help mitigate the stress of overreaching, which will improve performance. Thus, the investigators will compare the effects of two diets that differ in terms of protein servings (dose, timing, quality). In Study 2, skeletal muscle biopsies will be collected to determine how dietary protein intervention impacts the quality and quantity of skeletal muscle mitochondria in response to intense training.

For study 1, the objective is to determine the reliability and validity of 4-min and 20-min time trial performance (mean power output).

For study 2, the objective is to (1) determine whether following an optimal protein diet during a period of intense training will, relative to a typical diet: (1) improve measures of exercise performance, (2) improve sleep quality, psychological wellbeing, and immune function, (3) improve the quality and quantity of skeletal muscle mitochondria.

Study 1 is a reliability and validity experiment designed to assess the key outcome measure in study 2.

Study 2 is a randomized, crossover study. Participants will, in a randomized order, complete both conditions, separated by a 4-day washout period. ;

Study Design

Related Conditions & MeSH terms

Muscle Protein Synthesis

Clinical Trial Details

NCT number	NCT03994198
Study type	Interventional
Source	McMaster University
Contact
Status	Completed
Phase	N/A
Start date	November 1, 2017
Completion date	August 30, 2018

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05386771` - Effects of Whey and Collagen Protein Blend on Protein Synthesis Rates	N/A
Recruiting	`NCT05711095` - The Anabolic Properties of Fortified Plant-based Protein in Older People	N/A
Withdrawn	`NCT00653679` - Exercise and Muscle Protein Signalling	N/A
Completed	`NCT03372928` - Essential Amino Acids and Protein Kinetics During Caloric Deprivation	N/A
Completed	`NCT04121689` - Time Course of Postprandial Protein Metabolism	N/A
Completed	`NCT03303729` - Influence of Carbohydrate on Amino Acid Absorption From Dietary Protein (ICADP)	N/A
Not yet recruiting	`NCT02732353` - Absorption and Muscle-stimulating Effect of Hydrolyzed and Minced Beef	N/A
Completed	`NCT04302038` - The Effects Potato Protein on Rates of Myofibrillar Muscle Protein Synthesis in Young Women	N/A
Active, not recruiting	`NCT05347667` - Menstrual Cycle Phase Muscle Protein Synthesis	N/A
Completed	`NCT04894747` - Mycoprotein and Pea Protein Blend and Muscle Protein Synthetic Response	N/A
Recruiting	`NCT05664269` - Anabolic Properties of Canola	N/A
Completed	`NCT05353595` - The Effect of Mealworm Protein Ingestion on Muscle Protein Synthesis After Running Exercise in Humans	N/A
Completed	`NCT05151887` - The Impact of a Whole-food Animal-based Versus Plant-based Protein Rich Meal on Muscle Protein Synthesis	N/A
Recruiting	`NCT04232254` - Defining Beef and Meal Frequency as Key Components of a Healthy Eating Pattern for Muscle Health and Wellbeing	N/A
Completed	`NCT04981652` - The Effect of Whole Milk to Improve Muscle Health in Older Women	N/A
Recruiting	`NCT05876299` - The Anabolic Properties of a Lipid-rich Pork Matrix	N/A
Completed	`NCT02282566` - Effect of Protein-nutrition Beverages on Muscle Protein Synthesis in Women	N/A
Completed	`NCT01885429` - Effect of Supplementing a Mixed Macronutrient Beverage With Graded Doses of Leucine on Myofibrillar Protein Synthesis	N/A
Completed	`NCT05178732` - The Effect of Menstrual Cycle Phase and a Protein-polyphenol Drink on Muscle Protein Synthesis	N/A
Completed	`NCT05679596` - Exogenous Ketosis During Bed Rest in Older Adults	N/A