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NCT05178732 Clinical Trial

The Effect of Menstrual Cycle Phase and a Protein-polyphenol Drink on Muscle Protein Synthesis

Muscle Protein Synthesis Clinical Trial

Official title:
The Effect of Menstrual Cycle Phase on Muscle Protein Synthesis in Response to Exercise and a Protein-polyphenol Drink in Young Females

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05178732
Other study ID # 21-10-20-B-03
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date January 16, 2022
Est. completion date March 31, 2023

Study information
Verified date November 2023
Source University of Exeter
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Amino acid (building blocks of protein) and polyphenol supplements are commonly consumed post resistance exercise in order to aid muscle recovery. Both supplements have been shown to be beneficial in isolation, however, there is little known about the effect on recovery of combining the two. Muscle recovery is related to the ability to build new muscle protein from amino acids (muscle protein synthesis). This response is thought to be impacted in females by hormones that fluctuate across different phases of the menstrual cycle. However, the effect of menstrual cycle phase on muscle protein synthesis during recovery is not known.

Recruitment information / eligibility
Status Completed
Enrollment 28
Est. completion date March 31, 2023
Est. primary completion date February 28, 2023
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 18 Years to 40 Years
Eligibility Inclusion Criteria: - BMI between 18 and 30 - Recreationally active - Regular menstrual cycle Exclusion Criteria: - Smoking - Metabolic disease - Any motor disorder - Use of over-the-counter pharmaceuticals, during the study. - Pomegranate, milk or lidocaine allergy - Taken contraceptives in the past 3 months - Irregular menstrual cycle (less than 9 cycles per year and a length not between 21-35 days) - Post-menopausal women - Pregnancy and lactation

Study Design

Related Conditions & MeSH terms

Intervention

Dietary Supplement:
• Bolus ingestion of protein
Different phases of the menstrual cycle
• a blend of protein and polyphenol
a blend of protein and polyphenol

Locations
Country Name City State
United Kingdom University of Exeter Exeter Devon

Sponsors (2)
Lead Sponsor Collaborator
University of Exeter P.volve LLC

Country where clinical trial is conducted

United Kingdom, 

Outcome
Type Measure Description Time frame Safety issue
Primary Muscle protein synthesis The rate of synthesis of new muscle protein 7.5 hours
Secondary Plasma amino acid kinetics The appearance of amino acids in the circulation. 7.5 hours
Secondary Serum insulin concentrations Basal and postprandial concentrations of serum insulin 7.5 hours
Secondary Blood flow Basal and postprandial blood flow using ultrasound 7.5 hours
Secondary Sex hormone concentrations Serum oestrogen and progesterone 5 minutes
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