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NCT04894747 Clinical Trial

Mycoprotein and Pea Protein Blend and Muscle Protein Synthetic Response

Muscle Protein Synthesis Clinical Trial

— BPM  

Official title:
Comparing Postprandial Muscle Protein Synthesis Rates Following the Consumption of Mycoprotein, Pea Protein and a Mycoprotein/Pea Protein Blend in Resistance Trained Individuals

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04894747
Other study ID # 200325_B_04UOE
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date May 1, 2021
Est. completion date June 15, 2022

Study information
Verified date March 2023
Source University of Exeter
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Dietary protein is vital for the preservation of health and optimal adaptation to training. Plant proteins are considered inferior to animal proteins with respect to their ability to stimulate an acute muscle building response and therefore support long-term muscle reconditioning. Pea protein is a highly commercially available plant proteins source (available as supplements, food ingredients etc.), yet there is no research investigating its ability to stimulate a muscle building response. The investigators aim to assess the effect of consuming pea protein on muscle protein synthesis rates and compare these results to mycoprotein, a source known to elicit a robust anabolic response. Pea protein is lower in some of the essential amino acids, namely methionine, which could mean it is less effective compared with mycoprotein which has a more complete amino acid profile. So in addition to comparing pea with mycoprotein, the investigators also want to compare to a blend of pea and mycoprotein to see if replenishing the amino acid content in pea 'rescues' the anabolic response.

Recruitment information / eligibility
Status Completed
Enrollment 33
Est. completion date June 15, 2022
Est. primary completion date June 15, 2022
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 40 Years
Eligibility Inclusion Criteria: - BMI between 18 and 30 - Resistance trained Exclusion Criteria: - Any metabolic impairment - Smoking - Use of over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices). - A personal family history of epilepsy, seizures or schizophrenia. - Allergic to Quorn/mycoprotein/edible fungi/environmental mould products. - Any motor disorder.

Study Design

Related Conditions & MeSH terms

Intervention

Dietary Supplement:
• Bolus ingestion of protein
Ingestion of 25g of protein

Locations
Country Name City State
United Kingdom University of Exeter Exeter

Sponsors (2)
Lead Sponsor Collaborator
University of Exeter Quorn

Country where clinical trial is conducted

United Kingdom, 

Outcome
Type Measure Description Time frame Safety issue
Primary Muscle protein synthesis The rate of synthesis of new muscle protein (Fractional synthetic rate %/h) 8.5 hours
Secondary Plasma amino acid kinetics The appearance of amino acids from the protein drink in the circulation. 8.5 hours
Secondary Serum insulin concentrations Basal and postprandial concentrations of serum insulin 8.5 hours
Secondary Translocation of mTOR via immunohistochemistry Locality of mTOR within the muscle cell 8.5 hours
Secondary mTOR phosphorylation via ATP kinase assay The amount of mTOR that has been activated in the muscle cell 8.5 hours
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