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NCT ID: NCT06358040 Not yet recruiting - Pain, Postoperative Clinical Trials

Opioid Dispenser for Microdiscectomy/Laminectomy

Start date: July 2024
Phase: N/A
Study type: Interventional

The opioid crisis continues to plague the United States. While great strides have been made nationwide to decrease overprescribing, improvements are still needed to appropriately educate patients on the safe and responsible use, storage and disposal of opioids. Pain after surgery is often treated with opioid medications. Opioid medications can have side effects. Some side effects are relatively minor (constipation, nausea, vomiting), while others are more severe (sedation, abnormal breathing, etc.) and can lead to serious illness or death. Opioid pain medications when used the wrong way may also be addictive. Due to theses side effects, sometimes patients feel uncomfortable about taking these medications, and doctors prescribe them very cautiously. However, when used properly and safely, opioid pain medications are excellent pain relievers. Addinex, a technology company, has developed a device to help patients take opioids more safely. In this study the investigators aim to enroll a total of 30 patients who undergo spine surgery. Half will be randomly assigned to receive a standard pill bottle with opioids at discharge and will download a mobile app so that they can record their daily pain scores and the number of opioids they take for two weeks after surgery. The other half will receive the new opioid dispenser filled with opioids and a mobile app that generates a passcode that opens that device only at designated times. For this group of patients, every time the patient wants to take an opioid, they need to go to the app, enter their pain score before the app generates a passcode. The investigators will be tracking all study patients' opioid use and pain scores for the two weeks after surgery, will count how many pills they have left over 14 days after their surgery during a live telehealth session, and ask patients how they liked using the device. Results from this study will help understand if the Addinex device could potentially be useful to patients in the future after surgeries as opposed to typical pill bottles.

NCT ID: NCT06346132 Not yet recruiting - Pain Clinical Trials

Effect of Virtual Reality on Patient's Comfort During Cardiac Electronic Device Implantation.

Start date: April 1, 2024
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the effect on patient's comfort of a virtual reality experience during a procedure of cardiac electronic device implantation under local anesthesia.

NCT ID: NCT06334523 Not yet recruiting - Clinical trials for Ventilator-Induced Lung Injury

Ventilation of the Extremely Premature Infants Optimized by Dead Space Washout

Volem
Start date: November 1, 2024
Phase: N/A
Study type: Interventional

The Continuous Tracheal Gas Insufflation (CTGI) is a ventilation option of conventional ventilation to reduce or even cancel dead space due to respiratory prostheses. This objective is particularly interesting in the smallest preterm infants in which the volume of anatomical dead space due to prostheses is little different from the tidal volume. The principle of this option is to continuously blow an additional flow of 0.2 L/min at tip of endotracheal tube to purge expired CO2 trapped in the prostheses to have a CO2-free volume of gas available for subsequent insufflation.

NCT ID: NCT05921344 Not yet recruiting - Type 2 Diabetes Clinical Trials

Preclinical Research of mμSORS for Noninvasive Blood Glucose Detection

Start date: June 20, 2023
Phase: N/A
Study type: Interventional

This is a single-center, open-label, prospective study. Blood glucose was measured at different time points during oral glucose tolerance testing in patients with type 2 diabetes mellitus, using both venous plasma and multi-channel microspatial offset Raman scattering spectroscopy (mμSORS). Venous plasma glucose was set as gold standard.The two measurements were collected synchronously so as to calculate the mean absolute relative difference (MARD) and the consensus error grid (CEG). Accuracy of non-invasive blood glucose testing by mμSORS will be validated. MARD for two measurement methods in different blood glucose ranges and the safety outcomes of mμSORS such as adverse events will also be assessed.

NCT ID: NCT05909605 Completed - Medical Device Clinical Trials

Clinical Feasibility of a Conformal Ultrasound Blood Pressure Sensor

Start date: October 20, 2020
Phase:
Study type: Observational

Blood pressure (BP) monitoring is essential for managing cardiovascular diseases. Arterial line (A-line), the clinical gold standard for BP monitoring, is too invasive for routine measurements. The sphygmomanometer, on the other hand, is non-invasive but captures only discrete values. The recently introduced conformal ultrasound sensor offers non-invasive and continuous monitoring of BP, which can potentially improve the quality of patient care, but its accuracy has yet to be thoroughly validated. Here the investigators are working to validate the accuracy of a redesigned ultrasound sensor with enhanced reliability in BP measurements at-home and in clinics even under different interventions.

NCT ID: NCT05781295 Recruiting - Children Clinical Trials

Multicentre Randomised Study Comparing a Taurolidine Lock and a Standard Saline Lock in Paediatric Oncology

PEDIALOCK
Start date: January 19, 2024
Phase: N/A
Study type: Interventional

Interest of a Taurolidine lock at each catheter closure in the primary prevention of catheter-related endoluminal infection in paediatric oncology. Multicentric, controlled, randomized and double-blind label study.

NCT ID: NCT05504005 Not yet recruiting - Diabetes Mellitus Clinical Trials

Clinical Validation of mμSORS for Noninvasive Blood Glucose Detection

Start date: August 19, 2022
Phase: N/A
Study type: Interventional

This is a single-center, open-label, prospective study. Blood glucose was measured at different time points during oral glucose tolerance testing in healthy subjects and patients with type 2 diabetes mellitus, using both venous plasma and multi-channel microspatial offset Raman scattering spectroscopy (mμSORS). Venous plasma glucose was set as gold standard.The two measurements were collected synchronously so as to calculate the mean absolute relative difference (MARD) and the consensus error grid (CEG). Accuracy of non-invasive blood glucose testing by mμSORS will be validated. MARD for two measurement methods in different blood glucose ranges and the effect of mμSORS on safety in the patient such as adverse events will also be assessed.

NCT ID: NCT05380310 Not yet recruiting - Medical Device Clinical Trials

Impact on the Time to Diagnosis of Serious Postoperative Complications by a Controlled Connected Medical Device

SMARTANGEL
Start date: June 1, 2022
Phase: N/A
Study type: Interventional

Post-operative mortality in case of scheduled surgery is 3% in France (Lancet 2013) mainly due to cardiovascular or respiratory complications, by decompensation of pre-existing pathologies. Complications due to the medical practice are the third cause of morbidity (BMJ, 2016). More than half are preventable and are mainly observed in surgical patients. In conventional hospitalization, excluding intensive care, monitoring is done discontinuously for most of the patients, which does not allow early diagnosis of a vital cardiovascular or respiratory failure. Diagnosis and late treatment do not allow good recovery. The early identification of a vital failure by the continuous monitoring of three simple physiological parameters (SpO2, heart rate and respiratory rate) would allow faster management by the hospital staff and a reduction in immediate and possibly delayed postoperative mortality.

NCT ID: NCT05329246 Completed - Clinical trials for Cardiovascular Diseases

Validation of PMcardio AI-assisted Clinical Assistant in Primary Care

PMCARDIO-PT1
Start date: November 22, 2021
Phase: N/A
Study type: Interventional

This study aimed to analyze and investigate whether the use of the PMcardio clinical assistant leads to a more efficient patient management in primary care and more accessible specialised care compared to usual standards of care and to assess the reliability and safety of the PMcardio smartphone application in the primary care use environment. Additionally, to evaluate time savings and cost saving implications of increased availability of specialised care at the primary care level.

NCT ID: NCT05294016 Recruiting - Breast Cancer Clinical Trials

Smart Bra for Diagnosing Breast Cancer

CBRA
Start date: April 13, 2022
Phase: N/A
Study type: Interventional

This project aims to assess the ability of a portable and connected medical device to detect breast abnormalities, for breast cancer screening. It will accelerate technological progress in the face of breast cancer.