Lipopolysaccharide (LPS) Challenge in Depression

Status Completed

Clinical Trial Summary

LPS Challenge in Individuals with Major Depressive Disorder

Clinical Trial Description

The aim of this project is to understand the biological differences between two distinct subtypes of depression, patients with and without inflammation as defined by c-reactive protein (CRP). Using a double-blinded, parallel group, placebo-controlled design, participants will be phenotyped before and after a low-dose lipopolysaccharide (LPS) challenge designed to perturb the immune system and trigger a transient, mild inflammatory response. This experimental design will allow for the delineation of the homeostatic mechanisms underlying sensitivity to inflammation-related depression. Low-dose LPS has been used by multiple groups to safely induce transient inflammatory responses in humans. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03142919
Study type	Interventional
Source	Laureate Institute for Brain Research, Inc.
Contact
Status	Completed
Phase	Phase 2
Start date	September 7, 2017
Completion date	December 1, 2020

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