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Depressive Disorder clinical trials

View clinical trials related to Depressive Disorder.

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NCT ID: NCT05206734 Active, not recruiting - Schizophrenia Clinical Trials

Risk of Mental Health Conditions in Children and Young Adults With Inflammatory Bowel Disease and Influence on Health

Start date: January 5, 2022
Study type: Observational

This study is a large population-based analysis in the United Kingdom (UK) using routine primary care data to investigate the risk of mental health conditions in children, adolescents and young adults with Inflammatory Bowel Disease, compared to those without Inflammatory Bowel Disease. The study will also compare the impacts on quality-of-life outcomes and use of healthcare services between people with Inflammatory Bowel Disease with and without mental health conditions.

NCT ID: NCT05205915 Not yet recruiting - Clinical trials for Major Depressive Disorder

Home-based Transcranial Direct Current Stimulation (tDCS) for Major Depressive Disorders (MDD)

Start date: February 2022
Phase: N/A
Study type: Interventional

This is an open label pilot feasibility telemedicine study. This pilot will involve a total of 37 at-home stimulation sessions (30-minutes each) of multichannel excitatory tDCS targeting the left dorsolateral prefrontal cortex (DLPFC) administered over 8 weeks, with a follow-up period of 4 weeks following the final stimulation session.

NCT ID: NCT05203861 Recruiting - Depression Clinical Trials

Positive Affect Treatment for Anhedonia, Depression, and Anxiety

Start date: November 22, 2021
Phase: N/A
Study type: Interventional

Affect, or the tendency to experience a given emotion, often is subdivided into two domains. Positive affect is the tendency to experience positive emotions, such as happiness, excitement, elation, and enthusiasm. Negative affect is the tendency to experience negative emotions, such as anger, resentment, sadness, anxiety, and fear. Humans exhibit a range of emotions that span across positive and negative affect domains with some individuals experiencing more of one type of affect than another. Recent research and developing theories have suggested that mental health disorders often involve extremes of positive and negative affect. Therefore, rather than targeting symptoms per se, treatments may be more effective by targeting underlying dysregulation in positive and negative affect. The current study plans to recruit participants for a treatment trial consisting of two psychotherapies: (a) positive affect treatment (PAT), and (b) negative affect treatment (NAT) and to assess the effects on reward and threat sensitivity. Participants will be randomized to either a 15-week positive (PAT) or negative affect treatment (NAT). Participants will complete five laboratory visits (before treatment, during treatment (two times), post-treatment, and 1-month follow-up) to measure potential targets or mediators of PAT. These laboratory-based assessments will include measures of the positive affect system such as experiential, behavioral, and physiological responses to reward, anticipation and motivation, reward attainment, and reward learning and experiential, behavioral, and physiological measures of the negative affect system.

NCT ID: NCT05203341 Recruiting - Clinical trials for Major Depressive Disorder

Study to Assess the Efficacy and Safety of Adjunctive NBI-1065845 in Adults With Major Depressive Disorder (MDD)

Start date: January 2022
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the efficacy of NBI-1065845 compared with placebo used in addition to oral antidepressants in adults with MDD on improving symptoms of depression.

NCT ID: NCT05203198 Recruiting - Depression Clinical Trials

The PATHway Study: Primary Care Based Depression Prevention in Adolescents

Start date: December 1, 2021
Phase: N/A
Study type: Interventional

Prevention of depressive disorders has become a key priority for the NIMH1, but we have no widely available public health strategy to reduce morbidity and mortality. To address this need, we developed and evaluated the primary care based-technology "behavioral vaccine," Competent Adulthood Transition with Cognitive-Behavioral Humanistic and Interpersonal Therapy (CATCH-IT). We will engage N=4 health systems representative of the United States health care system, and conduct a factorial design study to optimize the intervention in preparation for an implementation study and eventual dissemination.

NCT ID: NCT05202119 Not yet recruiting - Clinical trials for Major Depressive Disorder

tDCS in Major Depressive Disorder

Start date: January 22, 2022
Phase: N/A
Study type: Interventional

A two-center trial to investigate whether or not active stimulation with the Flow FL-100 tDCS device is superior to sham stimulation for the treatment of major depressive disorder when used at home.

NCT ID: NCT05196971 Recruiting - Clinical trials for Treatment Resistant Depressive Disorder

A Study To Evaluate The Safety, Tolerability And Pharmacokinetics of HS-10345 In Treatment-Resistant Depression

Start date: October 28, 2021
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the safety, tolerability and pharmacokinetics of intranasal HS-10345 (84mg) compared with placebo in participants with treatment-resistant depression (TRD).

NCT ID: NCT05196152 Not yet recruiting - Clinical trials for Postpartum Depression

MomMoodBooster VA Program

Perinatal MMB
Start date: January 10, 2022
Phase: N/A
Study type: Interventional

The MomMoodBooster intervention is an empirically validated treatment for postpartum depression symptoms. The intervention was created by Brian Danaher and Milagra Tyler, who have continued to update the intervention technology and content. The intervention is now available for pregnant and postpartum Veterans, and it is accessible on browsers via computer, tablet, or mobile phone. The intervention contains six cognitive-behavioral modules that span six weeks, and it includes identification of pleasant activities, tracking mood and thoughts, and identification of goals. The current trial is an expansion of a nationwide service delivery project that has been ongoing for six years with the goal of offering the intervention to postpartum Veterans nationwide. Within that study, Veterans completed the online modules in concert with weekly phone coaching calls wherein coaches applied the content to the Veteran's current life. In addition, two booster modules and associated coaching calls were developed to continue application of the skills beyond the six-week intervention period. The present study seeks to investigate the incremental utility of the phone coaching component of the intervention by randomizing pregnant and postpartum Veterans to the MomMoodBooster intervention or the MomMoodBooster intervention plus phone coaching. Primary outcomes will include depressive symptoms, behavioral activation, and negative automatic thoughts.

NCT ID: NCT05195203 Enrolling by invitation - Clinical trials for Major Depressive Disorder

A Study of HS-10353 in Chinese Participants.

Start date: January 27, 2021
Phase: Phase 1
Study type: Interventional

The primary objective of this study is to assess the safety and tolerability of single and multiple oral administered doses of HS-10353 separately in Chinese healthy and major depressive disorder subjects.

NCT ID: NCT05194332 Not yet recruiting - Clinical trials for Depressive Disorder, Major

Transcranial Low Intensity Focused Ultrasound Neuromodulation as a Probe to Study Human Emotion and Cognitive Function

Start date: January 24, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the low-intensity focused ultrasound pulsation (LIFUP) neuromodulation on emotion processing in healthy individuals, and to assess the overall safety of the LIFUP to stimulate or inhibit brain activity in healthy volunteers.