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NCT01860898 Clinical Trial

A Phase I Study of iPS Cell Generation From Patients With COPD

Lung Cancer Clinical Trial

Official title:
A Phase I Study of iPS Cell Generation From Patients With COPD

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01860898
Other study ID # 09-005334
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date September 2009
Est. completion date October 28, 2014

Study information
Verified date September 2022
Source Mayo Clinic
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

As part of the long-term goal of successfully implementing tissue regeneration strategies in an individualized manner for patients with thoracic diseases including, but not limited to: cystic fibrosis, pulmonary fibrosis and pulmonary hypertension, the investigators will assess the feasibility of collecting skin biopsies from patients undergoing surgery for thoracic disease, culturing skin fibroblasts from the biopsy, and reprogramming these skin fibroblasts into induced pluripotent cells.

Recruitment information / eligibility
Status Completed
Enrollment 31
Est. completion date October 28, 2014
Est. primary completion date October 28, 2014
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Undergoing Thoracic Surgery at the Mayo Clinic Rochester - Presence of a Thoracic Disease

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Skin Biopsy
Biopsy samples will be taken as a 2mm x 2cm excision of a wedge of skin at the edge of the incision during your surgery at the Mayo Clinic Rochester. Such excisions are frequently done as part of routine skin closure for optimal skin cosmesis following the surgical procedure.

Locations
Country Name City State
United States Mayo Clinic in Rochester Rochester Minnesota

Sponsors (1)
Lead Sponsor Collaborator
Mayo Clinic

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Feasibility As part of the long-term goal of successfully implementing tissue regeneration strategies in an individualized manner for patients with thoracic diseases including, but not limited to: cystic fibrosis, pulmonary fibrosis and pulmonary hypertension, we will assess the feasibility of collecting skin biopsies from patients undergoing surgery for thoracic disease, culturing skin fibroblasts from the biopsy, and reprogramming these skin fibroblasts into induced pluripotent cells. Markers of induced pluripotent phenotype will be utilized to assess successful reprogramming. 1 year
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