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Clinical Trial Summary

This is a multicenter, open-label, phase I/II basket study, evaluating the safety, tolerability, RP2D, pharmacokinetics, pharmacodynamics and antitumor activity of EOS-448 combined with standard of care and/or with investigational therapies in participants with advanced solid tumors.: EOS-448 will be combined with pembrolizumab, a marketed anti-PD-1 antibody in one treatment arm and a second treatment arm will evaluate EOS-448 combined with inupadenant, an investigational adenosine A2A receptor antagonist.

Clinical Trial Description

The study will be conducted in multiple staged parts: - Part 1 consists of two dose finding cohorts evaluating safety and tolerability as well as determining the recommended phase 2 dose (RP2D) of EOS-448 combined with pembrolizumab (Part 1A) or with inupadenant (Part 1B), in participants with advanced solid tumors. - Part 2 is the expansion part of the study. It will further explore the safety, tolerability, anti-tumor activity as well as pharmacokinetics and pharmacodynamics of EOS-448 combined with pembrolizumab in participants with PD-L1 positive first line (1L) mNSCLC (Part 2A and 2B) or in participants with PD-L1 positive 1L mHNSCC (Part 2C and 2D) and, of EOS-448 combined with inupadenant in participants with anti-PD-(L)1 resistant metastatic cutaneous melanoma (Part 2E), treated at the respective combinations RP2D. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05060432
Study type Interventional
Source iTeos Therapeutics
Contact Clarisse Truong
Phone 0032477892186
Email [email protected]
Status Recruiting
Phase Phase 1/Phase 2
Start date September 6, 2021
Completion date September 2024

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