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Clinical Trial Summary

This is a multicenter, open-label, phase I/II basket study, evaluating the safety, tolerability, RP2D, pharmacokinetics, pharmacodynamics and antitumor activity of EOS-448 (also known as GSK4428859A or belrestotug) combined with standard of care and/or with investigational therapies in participants with advanced solid tumors.


Clinical Trial Description

The combinations evaluated will be: - EOS-448 combined with pembrolizumab, an anti-PD-1 antibody - EOS-448 combined with inupadenant an investigational adenosine A2A receptor antagonist - EOS-448 combined with dostarlimab an anti-PD-1 antibody - inupadenant combined with dostarlimab - EOS-448 combined with inupadenant and dostarlimab - EOS-448 combined with dostarlimab and standard of care chemotherapies in participants with NSCLC ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05060432
Study type Interventional
Source iTeos Therapeutics
Contact iTeos Belgium SA
Phone +32 71 91 99 33
Email clinical_info@iteostherapeutics.com
Status Recruiting
Phase Phase 1/Phase 2
Start date September 6, 2021
Completion date January 2025

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