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Pulmonary Emphysema clinical trials

View clinical trials related to Pulmonary Emphysema.

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NCT ID: NCT06249529 Recruiting - Emphysema or COPD Clinical Trials

Airway Bypass - Safety and Feasibility Study

AIRWAY
Start date: January 26, 2024
Phase: Early Phase 1
Study type: Interventional

The objective of this study is to evaluate its safety and feasibility of the Airway Bypass Stent System in patients with severe emphysema. The study will collect clinical data through 12 months to assess procedural and device safety.

NCT ID: NCT06181357 Not yet recruiting - COPD Clinical Trials

Trial Evaluating the Rate of Pneumothorax in Severe Emphysema Secondary to Endoscopic Volume Reduction With Two-stage ZEPHYR® Valves Versus Endoscopic Volume Reduction With One-stage ZEPHYR® Valves

REPEAT
Start date: March 15, 2024
Phase: N/A
Study type: Interventional

Chronic obstructive pulmonary disease (COPD) affects 3.5 million people and is the third leading cause of death worldwide. Emphysema involves air retention in the lungs and is ultimately responsible for a major deterioration in the quality of life. Available drug treatments have moderate efficacy whereas surgical lung volume reduction can improve exercise capacity when offered to a very selected population but at the cost of significant morbidity and mortality. Endoscopic Lung Volume reduction with ZEPHYR® valves improves respiratory function at rest, exercise tolerance and quality of life in patients with little or no interlobar collateral ventilation. If this technique has therefore proven its effectiveness, it is not devoid of complications and is notably responsible for pneumothorax in 27% of cases. The management of this complication is clearly codified, ranging from patient monitoring to the removal of one or more valves. It is therefore a subject of major concern for multiple reasons: high incidence, lengthening of hospital stay, increase in the overall cost of care, potential loss of benefit for the patient in the event of permanent withdrawal. valves and above all a potentially fatal event. A new strategy for implanting ZEPHYR® valves in two stages has been developed in Limoges University Hospital. This innovative algorithm has been evaluated in several non-comparative single or multicenter studies. In those studies, pneumothorax' rate secondary to lung volume reduction with endobronchial valves is rated between 4.5 and 12%. The efficacy of the treatment appears to be comparable with the data found in the trials evaluating in which the entire lobe was treated in one procedure. Moreover, despite two procedures, there does not seem to be any increased risk of occurrence of other complications. Finally, the systematic scheduling of a thoracic computed tomography between the two procedures showed that 26.6% of patients presented a reduction in volume greater than 350mL despite incomplete treatment. These data seem promising but no direct comparison with standard one-step treatment has ever been conducted so far.

NCT ID: NCT06163131 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

The Effect of Treatment of Emphysema With Endobronchial Valves on the Diaphragm Mobility

Start date: November 27, 2023
Phase:
Study type: Observational

In some patients with chronic obstructive pulmonary disease (COPD) the breathlessness is caused by hyperinflation of the lungs. This causes difficulty breathing air out and makes it harder to breath in new air and limits the movement of the diaphram. The diaphragm is the muscle used for breathing between the chest and the stomach. Some of these patients can receive treatment with endobronchial valves, where one-ways are inserted into the bronchial system the let out some of the excess air, and thereby relieve breathlessness. The goal of this observational study is to investigate the effect of endobronchial valves on the mobility of the diaphragm in patients with chronic obstructive pulmonary disease. The main questions it aims to answer are: - If the movement of the diaphragm improves after treatment with endobronchial valves. - If there is a link between improvement of diaphragm function and improvement of symptoms, lung function and physical ability. - If ultrasound scan immediately after the treatment will predict which patients will benefit from the treatment. Participants will undergo ultrasound before, 1 day after and 90 days after the procedure, and lung function examinations from their already planned control visits will be collected.

NCT ID: NCT06152107 Not yet recruiting - Severe Emphysema Clinical Trials

A Multi-center RCT to Evaluate Subsegmental BTVA Treatment for Severe Emphysema

BTVA
Start date: November 26, 2023
Phase: N/A
Study type: Interventional

To compare the efficacy and safety of subsegmental treatment and segmental treatment with InterVapor in patients with severe emphysema

NCT ID: NCT06068647 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Ultrasound and Respiratory Physiological Signals in Lung Diseases

SAURON
Start date: March 22, 2023
Phase: N/A
Study type: Interventional

The use of lung ultrasound is instrumental in the evaluation of many chest pathologies and its ability to detect pleuro-pulmonary pathology is widely accepted. However, the use of ultrasound to explore the state of the peripheral lung parenchyma, when the organ is still aerated, is a relatively new application. Horizontal and vertical artifacts are separate and distinct artifacts that can be seen during ultrasound examination of the lungs. While the practical role of lung ultrasound artifacts is accepted to detect and monitor many conditions, further research is needed for the physical interpretation of ultrasound artifacts. These artifacts are diagnostic signs, but we don't fully understand their origin. The artifactual information deriving from the surface acoustic interaction, beyond the pleural line, in the ultrasound images of the normally aerated and non-deflated lung, represents the final result of complex interactions of acoustic waves with a specific three-dimensional structure of the biological tissue. Thus, the umbrella term "vertical artifacts" oversimplifies many physical phenomena associated with a pathological pleural plane. There is growing evidence that vertical artifacts are caused by physiological and pathological changes in the superficial lung parenchyma. Therefore, the need emerges to explore the physical phenomena underlying the artifactual ultrasound information deriving from the surface acoustic interaction of ultrasound with the pleuro-pulmonary structures.

NCT ID: NCT06035120 Recruiting - Emphysema or COPD Clinical Trials

An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema

CONVERT_II
Start date: February 22, 2024
Phase: N/A
Study type: Interventional

This is a prospective, open-label, multi-center, single-arm study planned to enroll 200 subjects with heterogeneous emphysema and collateral ventilation (CV) in the target lobe. Subjects will undergo instillation of AeriSeal Foam in the target lobe and subsequent assessment of CV status using Chartis Pulmonary Assessment System. Subjects with CV- status will then undergo placement of Zephyr Valve in the target lobe for bronchoscopic lung volume reduction (BLVR) and be followed for 24 months.

NCT ID: NCT05949645 Recruiting - Emphysema or COPD Clinical Trials

Study to Assess Safety, Feasibility, and Preliminary Efficacy of the Apreo Implant for Severe Emphysema

BREATHE-2
Start date: August 15, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to test the feasibility of an implant for severe emphysema in up to 30 participants at up to 5 study centers located in Europe and the United Kingdom. The main questions this clinical trial aim to answer are: Is it safe? Does it work? Participants who meet eligibility criteria will have up to two procedures 30 days apart, in which up to 3 implants will be placed in each lung during the procedure(s). Participants will be asked to return for follow-up visits at 30 days, and 3, 6, and 12 months after the procedure(s).

NCT ID: NCT05897424 Not yet recruiting - Emphysema Clinical Trials

Open Label Extension Study of INBRX-101 in Adults With AATD Emphysema

ELEVAATE OLE
Start date: June 2024
Phase: Phase 2
Study type: Interventional

Phase 2 open label extension study to evaluate INBRX-101 in adults with AATD emphysema

NCT ID: NCT05856331 Recruiting - Emphysema Clinical Trials

Study of INBRX-101 Compared to Plasma-derived A1PI Therapy in Adults With AATD Emphysema

ELEVAATE
Start date: October 12, 2023
Phase: Phase 2
Study type: Interventional

Phase 2 study to compare INBRX-101 to plasma derived A1PI therapy in adults with AATD emphysema

NCT ID: NCT05854550 Recruiting - Emphysema or COPD Clinical Trials

First in Human Study to Assess an Implant to Treat Severe Emphysema

BREATHE-1
Start date: May 5, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to test the feasibility of an implant for severe emphysema in up to 30 participants. The main questions it aims to answer are: Is it safe? Does it work? Participants who meet eligibility criteria will have up to two procedures 30 days apart, in which up to 3 implants will be placed in each lung during the procedure(s). Participants will be asked to return for follow-up visits at 30 days, and 3, 6, and 12 months after the procedure(s).