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Knee Osteoarthritis clinical trials

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NCT ID: NCT06013306 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Long-Term Follow-up Study of Subjects With Knee Osteoarthritis Who Had Administered FURESTEM-OA Kit Inj. in K0701 Study

Start date: September 14, 2023
Phase:
Study type: Observational

Long-Term Follow-up Study of Subjects with Knee Osteoarthritis who had administered FURESTEM-OA Kit Inj. in K0701 study

NCT ID: NCT06004024 Not yet recruiting - Quality of Life Clinical Trials

Psychometric Properties of the Short Form 12-item (SF-12) Health Questionnaire in Individuals With Knee Osteoarthritis

SF-12
Start date: September 1, 2023
Phase:
Study type: Observational [Patient Registry]

Knee Osteoarthritis (OA) is one of the most common joint diseases with chronic low-severity inflammation. 80% of individuals with knee OA have limited movements; It was found that 25% of them could not do their daily work. In addition, it has been shown that the quality of life of individuals with OA is lower compared to healthy individuals. This showed that measuring and reporting quality of life should be mandatory in clinical studies conducted in individuals with knee OA. It was stated that the most frequently used general scales in the evaluation of quality of life in these individuals were SF-36 or SF-12. It takes a long time for the SF-36 to be filled by individuals, which creates a disadvantage for both patients and clinicians. Developed as a shorter alternative to SF-36, SF-12 has also been shown to give similar results to SF-36 in individuals with knee OA who have undergone total knee arthroplasty. However, the psychometric properties of SF-12 in individuals with knee OA have not been examined. The purpose of this study is to examine whether SF-12 is valid and reliable in individuals with knee OA and to determine the minimum detectable change (MDC) value.

NCT ID: NCT06000670 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Efficacy of Autologous Adipose Derived Stromal Vascular Fraction for Musculoskeletal Conditions

SVF
Start date: December 30, 2024
Phase: N/A
Study type: Interventional

clinical efficacy of autologous stromal vascular fraction SVF,for inflammatory and degenerative conditions of the knees

NCT ID: NCT05996224 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Allogenic Adipose-Derived Mesenchymal Progenitor Cells for the Treatment of Knee Osteoarthritis

Start date: October 2023
Phase: Phase 3
Study type: Interventional

Evaluate the efficacy and safety of Allogenic Adipose Tissue-Derived Mesenchymal Progenitor Cells Therapy

NCT ID: NCT05993637 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Comparison of Proprioception for HTO (High Tibial Osteotomy) and UKA (Unicompartmantal Knee Arthroplasty)

Start date: May 2024
Phase:
Study type: Observational

Osteoarthritis of the knee (KOA), a common degenerative joint disease, affects a significant part of the world's population. Although it can hold all the compartments in the knee joint, isolated medial compartment involvement has been reported in about 85% of individuals diagnosed with KOA. In the management of degenerative medial gonarthrosis; symptomatic relief and provide orthopaedic surgeons with the aim to slow down the progression of Total Knee Arthroplasty (TKA) unikompartmental knee arthroplasty (UKA) and high tibial osteotomy (HTO) is used. In recent years, HTO and UKA have been preferred more frequently among these surgical methods due to a number of advantages they provide for patients. As a result of the orthopedic surgeries performed, interventions are made on bone and joint structures and problems may occur in the proprioceptive inputs provided by the body. In UKA, a new joint structure is created by changing the bone structure and removing the tibial plateau, while in HTO, the existing bone structure is preserved and a positional change is created. Thus, while it is expected that the proprioceptive response to be different between the two surgeries, no studies have been found in the literature on this issue. Accordingly, the purpose of this study is to compare the effects of HTO and UKA surgeries applied to individuals diagnosed with medial gonarthrosis on the proprioception of patients and to examine the effects of HTO and UKA surgeries on patients diagnosed with medial gonarthrosis. H0: There is no difference between the surgical methods applied when the proprioception of patients with HTO and UKA surgeries planned for individuals with medial gonarthrosis is considered. H1: There is a difference between the surgical methods applied when the proprioception of patients with HTO and UKA surgeries planned for individuals with medial gonarthrosis are considered.

NCT ID: NCT05988307 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Effect of Percussion Massage Gun on Hamstrings Flexibility.

Start date: August 1, 2023
Phase: N/A
Study type: Interventional

The purpose of this study would be to investigate: - The effect of using percussion massage gun on Hamstring flexibility in patients with knee osteoarthritis. - The effect of using percussion massage gun on pain in patients with knee osteoarthritis. - The effect of using percussion massage gun on ROM in patients with knee osteoarthritis. - The effect of using percussion massage gun on knee function in patients with knee osteoarthritis.

NCT ID: NCT05986513 Not yet recruiting - Chronic Pain Clinical Trials

Brain MRI for Knee OA

Start date: September 1, 2023
Phase: N/A
Study type: Interventional

It has been estimated that 300 million people worldwide have osteoarthritis (OA), and this has increased by 97% over the past 25 years. OA is degenerative joint disease that has joint cartilage break down and causes the surrounding bone to change and rub. The pain and loss of mobility experienced by people with knee OA can seriously reduce quality of life, while pain management causes significant healthcare spending. Unfortunately, the pain associated with OA is complex and difficult to treat other than to have a total knee replacement surgery to replace the damaged bone and surrounding tissues with artificial ones. Our research study plans to use advanced magnetic resonance imaging techniques and novel analysis methods to determine if specific parts of the brain are responsible for difficult to describe and diagnose aspects of chronic pain. This study will help us better understand the effects of chronic pain in the brain and the results will help guide future research into new therapeutic options that would focus on relieving the brain dysfunction caused by chronic pain.

NCT ID: NCT05962463 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Pulsed Radiofrequency Therapy vs Canal Adductor Blockade in Knee Osteoarthritis

Start date: December 20, 2023
Phase:
Study type: Observational

This study is intended to prove the efficacy and safety of ultrasound-guided pulsed radiofrequency therapy on adductor canal nerves by patients with Knee osteoarthritis.

NCT ID: NCT05944627 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Evaluate Safety and Explore Efficacy of FURESTEM-OA Kit Inj. in Patients With Knee Osteoarthritis

Start date: July 6, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

A Single, Dose Escalation, Optimal Dose Finding Phase I/IIa Clinical Trial to Evaluate Safety and Explore Efficacy of the Single Treatment of FURESTEM-OA Kit Inj. in Patients with Knee Osteoarthritis

NCT ID: NCT05936060 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Cartilage Recovery in Adults With Knee Osteorthritis by Mesenchymal Cell Therapy: Randomized Trial of Radiologic and Clinical Outcomes

INMUNOCEM-OA
Start date: October 1, 2023
Phase: Phase 2
Study type: Interventional

The treatment of osteoarthritis (OA) of the knee remains still controversial. Despite that fact advanced stages with symptomatic and functional improvement are obtained with total knee replacement, however, there is no treatment that neither modifies the natural history of this disease, nor avoid joint replacement surgery in young patients in whom the prosthesis has conflictive indications. Moreover, prosthetic surgery leads to lower long-term survival and in older patients, higher morbidity and mortality. Cell therapy promises to be a treatment option through the use of mesenchymal cells with the capacity control inflammatory responses and trigger the differentiation into chondrocytes. Here we propose a randomized placebo-controlled clinical trial to evaluate radiologic and clinical outcomes in patients with knee OA.