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Knee Osteoarthritis clinical trials

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NCT ID: NCT03302832 Enrolling by invitation - Knee Osteoarthritis Clinical Trials

Effectiveness of Reduced Frequency Physical Therapy in Total Knee Arthroplasty

Start date: October 2017
Phase: N/A
Study type: Interventional

Rehabilitation after Total Knee Arthroplasty surgery involves physical therapy services to address limitations in range of motion, strength, and participation in normal daily activities. This investigation will compare the outcomes from standard physical therapy intervention in comparison to reduced frequency physical therapy sessions supplemented with in-home exercise equipment.

NCT ID: NCT03299439 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Acupuncture Treatment for Knee Osteoarthritis With Sensitive Acupoints and Tender Points

Start date: October 20, 2017
Phase: N/A
Study type: Interventional

The investigators plan to investigate the effectiveness of acupuncture at highly sensitive points, compared with lowly/non-sensitive points or no acupuncture (waiting-list), in improving pain, joint function and quality of life, among patients with KOA. The safety of acupuncture will also be assessed during the study period.

NCT ID: NCT03294408 Recruiting - Knee Osteoarthritis Clinical Trials

Multimodal Imaging of Subchondral Bone in Knee Osteoarthritis : Predictive Model

MOSART
Start date: November 29, 2016
Phase: N/A
Study type: Interventional

Predictive factors of osteoarthritis progression are not yet well understood. However, a growing role attaches importance to the subchondral bone. The aim of the present project is to determine predictive factors of progression of osteoarthritis at the knee by a multimodal characterization of subchondral bone by Medical Resonnance Imaging, direct high resolution digitization radiographs and bone texture analysis. At the end of the project, an innovative imaging device, combining semi-automatic softwares for texture analysis, control detection and image registration would be supplied. This will enable on the one hand a more accurate and reproducible way to measure the joint space width of the affected compartment and on the other hand, an assistance to better detect patients at risk of progression of their knee osteoarthritis. Identifying These "progressors" patients might permit their selection in clinical trials at baseline adapted to their severe disease, using for example biologic treatments targeting knee osteoarthritis. The main objective of this study is to analyze the predictive capacities of bone texture parameters measured on the high-resolution radiography of the knee on the structural evolution of the knee osteoarthritis at 3 years.

NCT ID: NCT03293238 Recruiting - Knee Osteoarthritis Clinical Trials

Ultrasound Guided Knee Injections in Musculoskeletal Medicine

PRISMM
Start date: November 3, 2011
Phase: N/A
Study type: Interventional

This study will compare the accuracy and patient reported outcomes between four different techniques used to perform a knee injection.

NCT ID: NCT03290365 Not yet recruiting - Knee Osteoarthritis Clinical Trials

The Combination Effect of Platelet-rich Plasma and Hyaluronic Acid for Knee Osteoarthritis

Start date: November 1, 2017
Phase: N/A
Study type: Interventional

Although platelet rich plasma (PRP) and Hyaluronic acid (HA) are beneficial for osteoarthritis of knee (OA knee), the combined effect of PRP with HA was not clear so far. Hence, investigator assess a prospective randomized double-blind controlled trial.

NCT ID: NCT03290170 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Radiostereometric Analysis of Gap Balancing Versus Measured Resection for the Journey II Total Knee Replacement

Start date: October 1, 2017
Phase: N/A
Study type: Interventional

This is a randomized study comparing the measured resection and gap-balancing surgical techniques for total knee replacement (TKR) using a cemented Journey II TKR implant system. We will be comparing the two surgical methods by evaluating implant migration using radiostereometric analysis (RSA) imaging, evaluating contact kinematics (knee mechanics) through RSA under dynamic conditions and comparing patient knee outcome scores.

NCT ID: NCT03289754 Not yet recruiting - Knee Osteoarthritis Clinical Trials

A Prospective Study to Evaluate the iTotal Knee and iPoly XE Tibial Inserts

Start date: October 1, 2017
Phase: N/A
Study type: Interventional

This study is designed to evaluate the clinical outcomes of subjects who have recently undergone surgery with the iTotal® Cruciate Retaining (CR) Total Knee Replacement System (KRS) who have also had iPoly XE Tibial Inserts implanted.

NCT ID: NCT03289416 Recruiting - Knee Osteoarthritis Clinical Trials

Bone Marrow Aspirate Compared to Platelet Rich Plasma for Treating Knee Osteoarthritis

EmCyte
Start date: December 5, 2013
Phase: Phase 4
Study type: Interventional

This study is intended to compare whether bone marrow aspirate concentrate or platelet rich plasma injections is more effective in treating knee osteoarthritis.

NCT ID: NCT03289078 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Evaluation of Functional Improvement After Spa Therapy in Fontcaude Center

FONTCAUDE
Start date: October 2017
Phase: N/A
Study type: Interventional

Evaluation of functional improvement after spa therapy in Fontcaude center, for knee osteoarthritis Background. Knee osteoarthritis is the first indication of spa therapy in rheumatology. This therapeutic represents a non pharmacological treatment and is recommended by OARSI. In order to obtain agreement for spa therapy, the center Fontcaude, needs to show clinical improvement for patients, as demonstrated in the Thermarthrose study. This center is near Montpellier and could improve patients localised in this area.

NCT ID: NCT03281837 Recruiting - Knee Osteoarthritis Clinical Trials

2 Weekly Intra-articular Hyaluronan Knee Injections, Given 1 wk. Apart, of HYMOVIS Combined With Physical Exercise Program (PEP) Compared to PEP Alone, in Relatively Young, Active Population of Subjects With Patellofemoral Osteoarthritis (PFOA) and/or Tibiofemoral Osteoarthritis (TFOA)

Start date: September 2017
Phase: N/A
Study type: Interventional

Knee osteoarthritis (OA) is among the most common causes of musculoskeletal pain and disability. At present, there is no cure for OA. Therefore, the primary aims of therapy are to reduce pain, maintain or improve function and mobility, and prevent or slow the progression of adverse changes to the joint tissues, while keeping potential therapeutic toxicities to a minimum. Current treatment guidelines begin with non-pharmacologic modalities, such as patient education, weight loss, and physical therapy. Several exercise-based therapeutic approaches, such as aerobic exercise programs, range-of-motion exercises, and muscle-strengthening exercises are recommended and have shown clinical benefit in randomized, controlled clinical trials. However, non-pharmacologic approaches frequently provide insufficient pain relief and restoration of function and mobility, and pharmacologic modalities become necessary. Although simple analgesics such as acetaminophen provide relief for many OA subjects with mild to moderate pain, alternatives should be considered for subjects who fail to obtain adequate symptomatic relief with these measures. This post-market, single blind, multicenter, randomized, controlled clinical study is designed to enroll a relatively young, active population of subjects with patellofemoral osteoarthritis (PFOA) and/or tibiofemoral osteoarthritis (TFOA), and to compare responses to treatment with 2 weekly intra-articular (IA) hyaluronan (HA) injections, with each injection given 1 week apart, of HYMOVIS combined with a physical exercise program (PEP) to PEP alone. Because PEP or exercise programs may be considered the first line standard of care in OA knee pain, particularly in younger, active patients, the hypothesis of the study is that Hymovis combined with PEP program provides greater relief of pain associated with knee OA in the enrolled study subjects than with use of PEP alone. The study provides for subjects randomized to the PEP alone study group to cross over to HYMOVIS+PEP if improvement has not been achieved by the 3 month follow up visit. Subjects will be recruited over a 6 month period. The duration of the trial per center will be approximately 15 months. This includes the enrollment period of 6 months, the follow-up period at 3 and 6 months and the additional follow-up period for patients who crossed-over; they will be followed for an additional 6 months following the initial 3month follow-up. The trial will end when the last subject makes the last visit.