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Knee Osteoarthritis clinical trials

View clinical trials related to Knee Osteoarthritis.

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NCT ID: NCT02802878 Recruiting - Knee Osteoarthritis Clinical Trials

Combined Application of Electrical Stimulation and Volitional Contractions for Muscle Strengthening and Knee Pain Inhibition (Seated Study)

Start date: June 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the efficacy of a 12-week low-load neuromuscular electrical stimulation with volitional contraction (NMES-VC) training program to improve quadriceps strength and activation, while not adversely affecting knee-related pain, activities of daily living or quality of life in women with knee pain. The primary outcome will be change in maximal isokinetic knee extensor torque. The investigators will test the following hypotheses. In comparison with low-load (40%) resistance training without electrical stimulation, a 12-week NMES-VC training program will: Hypothesis 1: Increase maximal isokinetic knee extensor torque Hypothesis 2: Increase rate of muscle force development Secondary questions and response variables Hypothesis 3: Not adversely affect knee pain or quality of life, assessed by the Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire Additional hypotheses in women with risk factors for incident symptomatic or progressive KOA: 1. Determine the extent to which NMES-VC-enhanced low-intensity resistance training increases quadriceps muscle rate of force development 2. Determine the extent to which NMES-VC enhanced low-intensity exercise is tolerated (using numeric rating scale survey "level of pain you experienced during the hybrid training or 40% isokinetic exercise") 3. Determine the extent to which NMES-VC-enhanced low-intensity resistance training increases physical function (20m walk, chair stand, stair climb times, KOOS) 4. Determine the extent to which NMES-VC enhanced low-intensity resistance training increases pressure pain threshold

NCT ID: NCT02784964 Recruiting - Knee Osteoarthritis Clinical Trials

Adipose-derived Stem Cells (ADSCs) for Knee Osteoarthritis

Start date: March 2016
Phase: Phase 1/Phase 2
Study type: Interventional

1. To assess the safety of allogeneic injection of expanded ADSCs to patients with knee osteoarthritis 2. To assess the efficacy of allogeneic injection of expanded ADSCs to patients with knee osteoarthritis

NCT ID: NCT02777684 Completed - Knee Osteoarthritis Clinical Trials

Motivators and Barriers to Physical Activity in Knee Osteoarthritis Patients: a Qualitative Study

Start date: June 2014
Phase: N/A
Study type: Observational

This study sought to better identify the motivators and barriers to osteoarthritic patients practising regular physical activity. This is a crucial step towards enabling each health professional to adapt their therapy recommendations, while taking into account the patient's overall lifestyle.

NCT ID: NCT02769572 Recruiting - Knee Osteoarthritis Clinical Trials

Moxibustion in Osteoarthritis of the Knee

Start date: May 2016
Phase: Phase 3
Study type: Interventional

This is a multicenter , double-blinded, double-dummy, randomized controlled clinical trial to evaluate the efficacy of moxibustion for osteoarthritis of the knee.

NCT ID: NCT02767492 Recruiting - Knee Osteoarthritis Clinical Trials

Steroid Injection vs. BioDRestore for Patients With Knee OA

Start date: May 2016
Phase: N/A
Study type: Interventional

This study will include patients who are diagnosed with knee OA and are recommended for a knee injection. Study subjects will be randomized to receive either the standard of care knee injection (steroid) or amniotic tissue injection (BioDRestore). Study subjects will be asked for permission for a baseline knee aspiration prior to the knee injection. At 6 months post-injection, knee aspirations will be taken and sent for analysis. Study subjects will be followed for 1 year post-injection to include range of motion measurements and patient-reported pain/functional outcome measurements. X-rays will also be taken at the 1-year post-injection appointment.

NCT ID: NCT02766231 Recruiting - Knee Osteoarthritis Clinical Trials

Physica CR and PS Clinical Trial

Start date: February 2016
Phase: N/A
Study type: Observational

Type & Design: Post-market, international, multicentre Prospective, parallel groups, open-label, baseline controlled Objectives: 1. Assessment of clinical, radiographic and patient-reported outcomes of Physica CR and PS designs 2. Incidence of adverse events and identification of possible risk factors for unsatisfactory results 3. Mid-term survivorship of the implants

NCT ID: NCT02765685 Recruiting - Knee Osteoarthritis Clinical Trials

Internal Compartment Knee Osteoarthritis: ODRA (Orthosis Distraction and Rotation for osteoArthritis) Made-to-measure Hinged Knee Brace Versus Usual Care.

ERGONOMIE
Start date: February 2015
Phase: N/A
Study type: Interventional

This is a biomedical study on a medical device. 120 patients will participate in this study and will be split into 2 groups: - 60 patients in the "usual care" group: these patients will receive the usual care proposed by their doctor for 12 months. - 60 patients in the "ODRA" group: these patients will wear the ODRA brace for 12 months in addition to their usual care. They will be instructed to wear the brace for at least 6 hours per day, 5 days per week and to take it off during rest periods when lying down. The distribution of patients in the groups will be randomized. For this study, patients will be followed for 12 months, spread over 3 visits: inclusion visit, follow-up visit at 6 months and 12 months.

NCT ID: NCT02761590 Recruiting - Knee Osteoarthritis Clinical Trials

Circuit Training on Knee Osteoarthritis Patients

Start date: March 2015
Phase: N/A
Study type: Interventional

Introduction: The increase in intermuscular adipose tissue (IMAT) can contribute to muscle weakness and consequently on progression of knee OA. The prescription of exercise protocols has been used as a treatment strategy to minimize some of the bouts. Circuit training (CT) involves the combination of strength training and aerobic in the same session and has shown benefits in body composition and physical function. But the literature is unclear with respect to the influences of CT in the concentration of IMAT in the population with knee OA. Objective: To investigate the influence of a 14-week CT protocol in body composition and thigh IMAT concentration as well as cartilage degradation indicators and systemic inflammation and its impact on quality of life in patients with knee OA.

NCT ID: NCT02759198 Recruiting - Knee Osteoarthritis Clinical Trials

A Clinical Trial of YH23537 in Patients With Knee Osteoarthritis

Start date: April 2016
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate efficacy and safety of YH23537 versus celebrex in patients with knee osteoarthritis.

NCT ID: NCT02753634 Active, not recruiting - Knee Osteoarthritis Clinical Trials

An Innovative Mind-motor Exercise Approach to Osteoarthritis Treatment

Start date: April 2015
Phase: N/A
Study type: Interventional

Osteoarthritis (OA) is a growing burden in an aging society. There are few proven treatments and hence disability contributes to poor quality of life and direct/indirect costs to society. OA symptoms include both increased pain and reduced mobility. Strength training and aerobic exercise has been shown to improve symptoms in OA; however, the impact of targeted mobility and balance training in patients with osteoarthritis is unclear. The investigators propose a novel, low-impact exercise modality that improves balance and gait. The results of this research project should improve patient options and improve knowledge in OA management.