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Knee Osteoarthritis clinical trials

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NCT ID: NCT03064139 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Mindful Walking Intervention for Knee Osteoarthritis

Start date: April 2017
Phase: N/A
Study type: Interventional

This study evaluates the feasibility of a mindful walking intervention for management of knee osteoarthritis. Half of the participants will receive the mindful walking intervention while the other half will receive education on osteoarthritis management.

NCT ID: NCT03058393 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Teach-Back for Knee Replacement Discussions

Start date: March 1, 2017
Phase: N/A
Study type: Interventional

The goal of this study is to analyze how using the teach-back communication technique can improve patient:provider communication surrounding the discussion of knee replacement options, specifically Total Knee Arthroplasty(TKA) or a Unicompartmental Knee Arthroplasty(UKA). Orthopedic residents, fellows, physician assistants, and attendings that agree to participate will be consented and patients that have a clinical indication for a TKA and a UKA will be recruited from participating providers clinical schedules. Patient:provider interactions will be recorded and then the providers will attend a 1 hour education lecture about how to use teach-back. After attending the lecture, additional patient:provider interactions will be recorded and analyzed via a qualitative approach. Additionally, providers will participate in a semi-structured interview to capture their perceptions of teach-back and what challenges and benefits they may derive from using it.

NCT ID: NCT03058380 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Stated-Preferences in Knee Arthroplasty

Start date: March 1, 2017
Phase: N/A
Study type: Observational

The primary objectives of this study are to apply best-practice stated-preference methods to quantify patient preferences for benefit-risk tradeoffs associated with arthroplasty treatment options for end-stage osteoarthritis of the knee. Duke will develop and administer stated-preference surveys to adult patients (Ages 40-80) with knee pain to collect preference data, estimate the relative importance of treatment features and outcomes, and estimate maximum acceptable risks for given benefits and minimum acceptable benefits for given harms. This study proposal describes plans for the patient stated-preference survey.

NCT ID: NCT03051984 Recruiting - Knee Osteoarthritis Clinical Trials

Skeletal Muscle Atrophy and Dysfunction Following Total Knee Arthroplasty

Start date: January 1, 2017
Phase: N/A
Study type: Interventional

Total knee replacement, or arthroplasty, is the final clinical intervention available to relieve pain and functional limitations related to advanced stage knee osteoarthritis. Despite its beneficial effects, the early post-surgical period is characterized by the erosion of lower extremity muscle size and strength that cause further disability and slow functional recovery. While the detrimental effects of this period on muscle are widely recognized, the mechanisms underlying these adaptations are poorly understood and there are currently no widely-accepted clinical interventions to counter them

NCT ID: NCT03048773 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Extracorporeal Shockwave Therapy for Knee Osteoarthritis

Start date: February 20, 2017
Phase: N/A
Study type: Interventional

Knee osteoarthritis is a common disease that causes joint pain, stiffness, and movement limitation. Nearly 50% in those 75 years and above are affected. In Taiwan, the reported prevalence was more than 6000 per year. The cause of pain is joint instability and structure changed, including hyaline articular cartilage lost, bony remodeling, capsular stretching and periartcular muscle weakness. Current guidelines for treatment of symptomatic knee osteoarthritis include exercise, anti-inflammatory drugs, transcutaneous electrical stimulation(TENS) and magnetic fields(MF) which reduce pain and improve the patient's quality of life. However, conservative therapies and oral supplements have been evaluated but are without clear efficacy. Prolotherapy is an injection therapy for chronic musculoskeletal pain. One of the hypotheses is stimulating local healing and current study demonstrated clinical benefit for pain and improvement of function. The effects of multi-point injections were more pronounced in several studies than single-point injection. Extracorporeal shock wave is common treatment for kidney stones, has been widely used in soft tissue diseases, such as calcified tendon lesions and plantar fasciitis. The theory of extracorporeal shock wave is energy of high-frequency vibration caused destruction of stones and other hard material and by increasing the rate of vascular regeneration in the injured area and increasing the rate of autologous tissue repair, possible biological processes include increased mesenchymal stem cell proliferation and differentiation, slowing the inflammatory response and antimicrobial efficacy. Current studies have shown equivalent clinical outcomes on calcific rotator cuff tendinopathy among extracorporeal shock wave therapy, sono-guided acupuncture and arthroscopic surgery and the extracorporeal shock wave has the advantage of non-invasive treatment. Taking the advantages of non-invasive treatment of extracorporeal shockwave. We want to design a randomized control trial by multi-point shockwave therapy and physical therapy compared with placebo shockwave therapy and physical therapy. Two randomized controlled trial (RCT) reported improvement in outcomes in response to shockwave therapy but were not methodologically rigorous. The investigators therefore conducted a two-arm RCT to assess the hypothesis that adults with symptomatic knee pain receiving shockwave therapy will report greater improvement in knee-related quality-of-life than sham shockwave therapy.

NCT ID: NCT03047564 Active, not recruiting - Knee Osteoarthritis Clinical Trials

Metal Ion Concentration Between Coated and Uncoated TKA

Start date: February 1, 2012
Phase: N/A
Study type: Interventional

Metal ion release from metal implants may have side effects. It can be reduced by coating of the implant. This study compares coated and uncoated TKA.

NCT ID: NCT03047252 Recruiting - Knee Osteoarthritis Clinical Trials

SWORD Phoenix Versus Standard of Care in the Rehabilitation After Total Knee Replacement

Start date: December 19, 2016
Phase: N/A
Study type: Interventional

The study was designed to evaluate the effectiveness of a novel kinematic biofeedback system - SWORD Phoenix- in the rehabilitation after total knee replacement . SWORD Phoenix allows the patients to perform independent rehabilitation sessions at home, under remote monitoring from the clinical team. The investigators hypothesize that the clinical outcomes of a home-based rehabilitation program will be at least similar to the outcomes of a traditional home-based rehabilitation with face-to-face sessions. This is a randomized controlled trial with active comparator. Patients will be enrolled and randomized pre-operatively into 2 groups: intervention group and control group. Both groups will perform 8 weeks of rehabilitation starting on day 7 after surgery. The intervention group will perform daily rehabilitation sessions at home using SWORD Phoenix, under remote monitoring from a physical therapist. The control group will perform 1h rehabilitation sessions 3 times a week, at home, given by a physical therapist. Outcomes will be measured at weeks 4 and 8. The primary outcome is the performance in the Timed-up-and-Go (TUG) test between in each patient in comparison with the pre-operative score. Secondary outcomes will be measured in term of: a) range of motion of the knee joint (flexion/extension); b) Knee Osteoarthritis Outcome Score); c) quality of life, as measured by the SF-36 scale.

NCT ID: NCT03039452 Recruiting - Knee Osteoarthritis Clinical Trials

High Intensity Interval Training in Osteoarthritis, Effects on Metabolomics

Start date: January 2017
Phase: N/A
Study type: Interventional

Purpose: The purpose of this study will be to examine the feasibility and acceptability of a 6-week high intensity interval training (HIIT) program in patients with knee OA symptoms ranging from mild to severe. A secondary purpose will be to evaluated changes in whole body metabolism induced by 6-weeks of HIIT. Participants: Fifteen patients (age 40-70 yrs; BMI 20-35 kg/m²) with symptomatic knee OA Procedures (methods): All participants will be assigned to the single-arm of the study in which all participants will receive 6 weeks of HIIT, delivered twice per week. Outcomes will be assessed at baseline and 6 weeks. The primary outcome will evaluate tolerability, feasibility, acceptability, compliance, and adherence to the HIIT program. Secondary outcomes will include whole body metabolism markers, inflammation, and a set of physical function including knee osteoarthritis symptomatic burden and pain, cardiorespiratory fitness, isometric knee extensor and flexor strength (factors associated with physical function and symptomatic knee OA progression), and body composition.

NCT ID: NCT03039153 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Pressure Ulcers in Knee Replacement Surgery

peripress
Start date: March 1, 2017
Phase: N/A
Study type: Observational

From the point of view of nursing to know exactly the different risk factors for the onset of pressure ulcers is very important as it allows to accurately orient preventive care interventions. All the variable that could influence the development of pressure ulcer in patients undergoing knee replacement surgery are identified and collected: age, sex, body max index, risk to develop Pressure Ulcer (braden score), treatment to prevent pressure ulcers (typology of the devices used, such as air mattresses with alternating or static pressure, heel drains, frequency of mobilization carried out by both the patient care), management of eventual incontinence (use of diapers, urinary catheter), type of anesthesia, type of analgesia, length of stay, the ASA physical status classification system (ASA score), comorbidity, cancer, use of devices for controlling the position of the operated limb (foam valve), the number of physical therapy sessions actually carried out.

NCT ID: NCT03032133 Recruiting - Knee Osteoarthritis Clinical Trials

Pain Control After Total Knee Arthroplasty

Start date: February 2016
Phase: N/A
Study type: Interventional

Patients are randomized to receive pain control after Total Knee Arthroplasty with either a regional pain catheter or a local intraarticular pain catheter. Pain, analgetic use and mobility is asessed.