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Knee Osteoarthritis clinical trials

View clinical trials related to Knee Osteoarthritis.

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NCT ID: NCT03160781 Completed - Knee Osteoarthritis Clinical Trials

Intraosseous PRP for Knee Osteoarthritis: Pilot Study

Start date: January 28, 2014
Phase: Phase 2
Study type: Interventional

The aim of this study was to assess a novel approach to treating severe knee osteoarthritis by targeting synovialmembrane, superficial articular cartilage, synovial fluid, and subchondral bone by combining intra-articular injections and intraosseous infiltrations of platelet rich plasma.This study explored a new strategy consisting of intraosseous infiltrations of platelet rich plasma into the subchondral bone in combination with the conventional intra-articular injection in order to tackle several knee joint tissues simultaneously.

NCT ID: NCT03155737 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Self-administered Acupressure for Knee Osteoarthritis: A Pilot Randomized Controlled Trial

Start date: June 1, 2017
Phase: N/A
Study type: Interventional

Objectives: To test the feasibility of the study design and clinical effects of self-administered acupressure on relieving knee osteoarthritis (OA) pain. Hypothesis: self-administered acupressure would have a superior beneficial effect compared to health education control group in terms of pain relief in patients with knee osteoarthritis across the 6-week study period. Design and subjects: A pilot randomized controlled trial. 36 subjects with knee OA will be recruited; 18 per group. All eligible subjects will be randomized to either self-administered acupressure or health education control group in 1:1 ratio. Interventions: Subjects in the self-acupressure group will attend two 1.5 hours training sessions to learn self-acupressure and will practice self-acupressure every morning and night for 6 weeks; subjects in the education control group will receive two 1.5 hours training sessions to learn the health information related to knee OA. Main outcome measures: The primary outcome measure is the numerical rating scale for knee pain. Other measures include Western Ontario and McMaster University Osteoarthritis Index, knees' range of motion (ROM), and SF-6D. Acceptability of the self-acupressure training course will also be evaluated. Data Analysis: Differences in the questionnaire scores and ROM will be examined using a mixed-effects model. Both completer and intention-to-treat analyses will be conducted. Effect sizes will be computed by dividing the difference in means by the pooled standard deviation.

NCT ID: NCT03152357 Recruiting - Knee Osteoarthritis Clinical Trials

A Retrospective Study to Evaluate the ConforMIS iUni, iDuo & iTotal® KRS

Start date: April 1, 2017
Phase: N/A
Study type: Observational

This study is designed to evaluate implant survivorship, patient satisfaction, and patient-reported outcomes of subjects who have undergone surgery with any of the following ConforMIS knee implants: the iUni®, iDuo® or iTotal® Cruciate Retaining (CR) Knee Replacement Systems.

NCT ID: NCT03136887 Not yet recruiting - Knee Osteoarthritis Clinical Trials

JOURNEY II XR Safety and Effectiveness PMCF

Start date: May 2017
Phase: N/A
Study type: Interventional

This study was designed to demonstrate the safety and performance of the JOURNEY II XR total knee system by evaluating implant survival rates at 10 years using Kaplan-Meier analysis. All participants will be implanted with the JOURNEY II XR total knee system.

NCT ID: NCT03125954 Recruiting - Knee Osteoarthritis Clinical Trials

Changes in Physical Inactivity in Patients With Knee Osteoarthritis

Start date: May 1, 2017
Phase: N/A
Study type: Observational

This is an objective cohort study using objective recording of physical activity (accelerometry) during and after the GLAiD intervention to investigate if a sedentary behavior change by participating in an 6-week physiotherapy-led exercise and education program (GLAiD) occurs. The GLAiD intervention is an education and exercise based intervention aiming at decreasing pain and improving function in patients with knee osteoarthritis. The primary outcome is change in objective recorded physical activity between baseline and follow-up.

NCT ID: NCT03122860 Recruiting - Knee Osteoarthritis Clinical Trials

A Study Evaluating the Safety and Efficacy of SM04690 for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis

Start date: April 24, 2017
Phase: Phase 2
Study type: Interventional

This phase 2 study is a placebo-controlled, double-blind, parallel group study of four concentrations of SM04690 (0.03, 0.07, 0.15, and 0.23 mg per 2 mL injection) injected intraarticularly (IA) into the target knee joint of subjects with moderately to severely symptomatic osteoarthritis (OA). Based on previous studies of SM04690, key phenotypes of laterality (unilateral vs bilateral) as well as chronic pain (as measured by the Widespread Pain Index) were identified as confounding variables impacting the overall assessment of both radiologic and clinical efficacy outcomes. The design of SM04690-OA-04 is based upon previous study designs while assessing strategies to combat the confounding impact of laterality and chronic pain. To evaluate the effect of IA vehicle injection on patient-reported outcomes (PRO) such as pain, stiffness, and function in OA, this study will also include two placebo cohorts-one cohort that receives a 2 mL IA injection of vehicle, and one cohort that receives a sham injection (i.e., a needle stick with 0 mL vehicle injected).

NCT ID: NCT03120988 Active, not recruiting - Knee Osteoarthritis Clinical Trials

Catabolic Marker Levels After Platelet Poor Plasma (PPP) Lavage

PPP
Start date: July 2016
Phase: Phase 1
Study type: Interventional

The purpose of this study is to understand how the components of osteoarthritic knee joint fluid (synovial fluid) change after lavage treatment with platelet poor plasma. Additionally, the study participants will complete outcome questionnaire surveys before and after the treatment in conjunction with when synovial fluid is removed from the knee (2, 4, and 6 weeks after lavage). This data will help determine if the treatment of an osteoarthritic knee joint with platelet poor plasma lavage is a suitable stand-alone therapy or to improve outcome by preparing a patient's knee for further regenerative therapies.

NCT ID: NCT03120052 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Physical Therapy Components for Maximum TKR Outcome

Start date: September 2017
Phase: N/A
Study type: Observational

The overall goal of this study is to identify what Physical Therapy care components are associated with the best patient-reported functional outcome after Total Knee Replacement (TKR) surgery. The investigators are specifically looking at outcomes at 6 and 12 months after surgery.

NCT ID: NCT03117959 Withdrawn - Knee Osteoarthritis Clinical Trials

TKA Using Patient-Specific Instrumentation

Start date: February 2014
Phase: Phase 4
Study type: Interventional

The purpose of our study is to determine if anatomic/kinematic total knee arthroplasties (TKAs) are superior to mechanical axis-referenced TKAs with respect to determinants of gait functionality, patient satisfaction and other objective tests of knee function as a potential indicator of long-term prosthesis outcomes. To our knowledge there has not been any literature comparing TKAs using the kinematic and mechanical axes with respect to gait analysis. A single study has compared gender-specific TKAs and found that there is no difference with respect to determinants of gait when using these prostheses (Thomsen et al, 2012), but again this study was not based on referencing off of the anatomical/kinematic axis of the knee. Our group is hoping that the small variability that may be detectable with the precision of gait analysis may be used as a predictor of future prosthesis outcome measures.

NCT ID: NCT03116230 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Gait Modification Treatments for Knee Pathology

Start date: July 2017
Phase: N/A
Study type: Interventional

The objective of this study is complete a longitudinal cross-over clinical study to investigate the effect of treatments for knee pathology, including cutaneous stimulation (skin vibration and soft knee brace), on locomotion tasks (i.e. walking, jogging, stair ascending and descending), muscle function, and pain/function.