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Knee Osteoarthritis clinical trials

View clinical trials related to Knee Osteoarthritis.

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NCT ID: NCT02777684 Completed - Knee Osteoarthritis Clinical Trials

Motivators and Barriers to Physical Activity in Knee Osteoarthritis Patients: a Qualitative Study

Start date: June 2014
Phase: N/A
Study type: Observational

This study sought to better identify the motivators and barriers to osteoarthritic patients practising regular physical activity. This is a crucial step towards enabling each health professional to adapt their therapy recommendations, while taking into account the patient's overall lifestyle.

NCT ID: NCT02769572 Recruiting - Knee Osteoarthritis Clinical Trials

Moxibustion in Osteoarthritis of the Knee

Start date: May 2016
Phase: Phase 3
Study type: Interventional

This is a multicenter , double-blinded, double-dummy, randomized controlled clinical trial to evaluate the efficacy of moxibustion for osteoarthritis of the knee.

NCT ID: NCT02767492 Recruiting - Knee Osteoarthritis Clinical Trials

Steroid Injection vs. BioDRestore for Patients With Knee OA

Start date: May 2016
Phase: N/A
Study type: Interventional

This study will include patients who are diagnosed with knee OA and are recommended for a knee injection. Study subjects will be randomized to receive either the standard of care knee injection (steroid) or amniotic tissue injection (BioDRestore). Study subjects will be asked for permission for a baseline knee aspiration prior to the knee injection. At 6 months post-injection, knee aspirations will be taken and sent for analysis. Study subjects will be followed for 1 year post-injection to include range of motion measurements and patient-reported pain/functional outcome measurements. X-rays will also be taken at the 1-year post-injection appointment.

NCT ID: NCT02766231 Recruiting - Knee Osteoarthritis Clinical Trials

Physica CR and PS Clinical Trial

Start date: February 2016
Phase: N/A
Study type: Observational

Type & Design: Post-market, international, multicentre Prospective, parallel groups, open-label, baseline controlled Objectives: 1. Assessment of clinical, radiographic and patient-reported outcomes of Physica CR and PS designs 2. Incidence of adverse events and identification of possible risk factors for unsatisfactory results 3. Mid-term survivorship of the implants

NCT ID: NCT02765685 Recruiting - Knee Osteoarthritis Clinical Trials

Internal Compartment Knee Osteoarthritis: ODRA (Orthosis Distraction and Rotation for osteoArthritis) Made-to-measure Hinged Knee Brace Versus Usual Care.

ERGONOMIE
Start date: February 2015
Phase: N/A
Study type: Interventional

This is a biomedical study on a medical device. 120 patients will participate in this study and will be split into 2 groups: - 60 patients in the "usual care" group: these patients will receive the usual care proposed by their doctor for 12 months. - 60 patients in the "ODRA" group: these patients will wear the ODRA brace for 12 months in addition to their usual care. They will be instructed to wear the brace for at least 6 hours per day, 5 days per week and to take it off during rest periods when lying down. The distribution of patients in the groups will be randomized. For this study, patients will be followed for 12 months, spread over 3 visits: inclusion visit, follow-up visit at 6 months and 12 months.

NCT ID: NCT02761590 Recruiting - Knee Osteoarthritis Clinical Trials

Circuit Training on Knee Osteoarthritis Patients

Start date: March 2015
Phase: N/A
Study type: Interventional

Introduction: The increase in intermuscular adipose tissue (IMAT) can contribute to muscle weakness and consequently on progression of knee OA. The prescription of exercise protocols has been used as a treatment strategy to minimize some of the bouts. Circuit training (CT) involves the combination of strength training and aerobic in the same session and has shown benefits in body composition and physical function. But the literature is unclear with respect to the influences of CT in the concentration of IMAT in the population with knee OA. Objective: To investigate the influence of a 14-week CT protocol in body composition and thigh IMAT concentration as well as cartilage degradation indicators and systemic inflammation and its impact on quality of life in patients with knee OA.

NCT ID: NCT02759198 Recruiting - Knee Osteoarthritis Clinical Trials

A Clinical Trial of YH23537 in Patients With Knee Osteoarthritis

Start date: April 2016
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate efficacy and safety of YH23537 versus celebrex in patients with knee osteoarthritis.

NCT ID: NCT02753634 Active, not recruiting - Knee Osteoarthritis Clinical Trials

An Innovative Mind-motor Exercise Approach to Osteoarthritis Treatment

Start date: April 2015
Phase: N/A
Study type: Interventional

Osteoarthritis (OA) is a growing burden in an aging society. There are few proven treatments and hence disability contributes to poor quality of life and direct/indirect costs to society. OA symptoms include both increased pain and reduced mobility. Strength training and aerobic exercise has been shown to improve symptoms in OA; however, the impact of targeted mobility and balance training in patients with osteoarthritis is unclear. The investigators propose a novel, low-impact exercise modality that improves balance and gait. The results of this research project should improve patient options and improve knowledge in OA management.

NCT ID: NCT02740231 Recruiting - Knee Osteoarthritis Clinical Trials

A Study on Visco-antalgic Intra-articular Administration in Symptomatic Knee Osteoarthritis

Start date: February 2016
Phase: Phase 2/Phase 3
Study type: Interventional

Osteoarthritis (OA) is the most common joint disease affecting millions of people around the world, for which there is unfortunately no cure. Among existing therapies, viscosupplementation, i.e., the injection of hyaluronic acid into the joint, has an established place in the symptomatic treatment of knee OA. The present Phase IIb/III aiming to assess the safety and efficacy of JTA-004 is organized in two phases. With results obtained in the first phase the best dose of JTA-004 is determined, and the efficacy of the selected dose will then be confirmed in the second phase.

NCT ID: NCT02734342 Recruiting - Knee Osteoarthritis Clinical Trials

Mixed Methods Assessment of Exercises for Knee OA

Start date: February 2016
Phase: N/A
Study type: Interventional

Osteoarthritis (OA) is a condition that causes cartilage loss, bony remodeling, joint stiffness and generalized muscle weakness. 90% of OA presentation has been reported within the leg; with 44% affecting the knee joint. Knee OA is expected to increase by 50% over the next twenty years due to an ageing population, obesity, and societal trends such as lack of activity. Only 13% of knee OA sufferers reach the recommended levels of exercise therefore an understanding of how psychological and functional relationships effect exercise engagement, which in turn would provide a more comprehensive rehabilitation programme for patients with knee OA. The aim of this study is to investigate exercise in knee OA and it it's correlation with fear of movement, using a mixed methods approach. Quantitative methodology will investigate lower limb exercises for pain and function and fear of movement. The desired outcome of the study will show that a reduction in pain with patient specific exercise will also reduce the fear of movement and allow patients to self-manage their symptoms without fear. Other quantitative factors such as intensity of exercise and postural stabilization using the Y balance test will also be utilized to review the functional relationship of muscle strength and balance to kinesiophobia. A semi-structured interview will be completed at the end of the course of treatment to highlight what patients think about exercise as an intervention. Participants aged forty-five and above with specific clinical symptoms will be invited into the study and will be asked to attend eight exercise sessions within a class environment, which will last for 1 hour within the Physiotherapy Department.