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Knee Osteoarthritis clinical trials

View clinical trials related to Knee Osteoarthritis.

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NCT ID: NCT03240913 Recruiting - Knee Osteoarthritis Clinical Trials

A PROMs Based Educational Tool (PROM-DA) for Patients Considering Total Knee Arthroplasty

Start date: June 19, 2017
Phase: N/A
Study type: Interventional

The primary objectives of this study are to: 1) develop an educational tool known as the Patient Reported Outcome Measure informed Decision Aid (PROM-DA) that will describe the options for patients considering total knee arthroplasty (TKA) surgery, and help them imagine what to expect if they choose either option; 2) assess the extent that the PROM-DA improves patients decision quality; 3) determine the feasibility of a larger trial to test the PROM-DA in multiple sites and more patients.

NCT ID: NCT03233620 Completed - Knee Osteoarthritis Clinical Trials

Effectiveness of Contemporary Knee Arthroplasty in Working-age Patients

Start date: March 1, 2012
Phase: N/A
Study type: Interventional

The aim of our study was to assess the effectiveness of contemporary knee arthroplasty in working-age patients (< 65 years) by conducting a prospective cohort study with 2-year follow up. Outcomes were measured comprehensively using various patient-reported outcome measures (PROMs) to provide information on the effect of knee arthroplasty on pain, satisfaction, physical activity, activities of daily living, and quality of life.

NCT ID: NCT03217513 Not yet recruiting - Osteoporosis Clinical Trials

Knee Osteoarthritis Outcome Measures in Arthritic Patients With Osteoporosis

Start date: September 1, 2017
Phase: N/A
Study type: Observational

The purpose of this study is to generate proof of concept human data by evaluating osteoarthritis outcome measures in arthritic patients that are prescribed Forteo® as the standard of care to treat their primary diagnosis of osteoporosis.

NCT ID: NCT03215602 Recruiting - Knee Osteoarthritis Clinical Trials

EXercise as TReatment for osteoArthritis

EXTRA
Start date: July 18, 2017
Phase: N/A
Study type: Interventional

Osteoarthritis (OA) of the knee is a chronic musculoskeletal disease, and a major cause of pain and disability worldwide. Exercise has previously demonstrated good effect in alleviating OA symptoms. However, optimal exercise modes in OA are currently unknown. This study seeks to evaluate the effects of supplementary focused, knee extensor strength training in addition to neuromuscular exercise (NEMEX) and education in people with OA of the knee as performed in Good Life with osteoArthritis in Denmark (GLA:D ᵀᴹ). Through a randomized design, study participants will either be allocated to 12 weeks (twice weekly) of NEMEX and education or 12 weeks (twice weekly) of NEMEX and education and focused, knee extensor strength training. The primary outcome measurement for this study is the Knee injury and Osteoarthritis Outcome Score, subscale Activities of Daily Living (KOOS-ADL), which is a self-reported questionnaire on daily life activities. Other outcomes include parameters of maximal muscle strength and muscle power, muscle imaging, physical function, pain and self-reported health status.

NCT ID: NCT03211663 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Performance of MOTO Medial® Unicompartmental Knee Arthroplasty

Start date: August 1, 2017
Phase: N/A
Study type: Interventional

This is a prospective, multi-center study, designed to assess mid-term performance of the MOTO Medial® Unicompartmental Knee Arthroplasty (UKA), with patient report outcomes, clinical findings and radiographic analysis.

NCT ID: NCT03211650 Recruiting - Knee Osteoarthritis Clinical Trials

Efficacy of Hyaluronic Acid and Platelet-rich Plasma Combination in Knee Osteoarthritis

Start date: October 14, 2016
Phase: Phase 4
Study type: Interventional

The purpose of this study is to evaluate the efficacy of intra-articular injections of combined hyaluronic acid and platelet-rich plasma in knee degenerative joint disease in improving joint function and reducing pain.

NCT ID: NCT03210584 Active, not recruiting - Knee Osteoarthritis Clinical Trials

Multimodal Evaluation of Cartilage Lesions of Patellofemoral Joint

MULTICART
Start date: October 2016
Phase: N/A
Study type: Observational

Evaluation and comparison of histological analysis, 9,4 tesla MRI, Full-Field Optical Coherence Tomography (FFOCT) and ultrasound-based navigation system for cartilage degeneration analysis of patellofemoral joint.

NCT ID: NCT03203408 Completed - Knee Osteoarthritis Clinical Trials

Efficacy of OSTENIL PLUS (Hyaluronic Acid) Versus SYNVISC-ONE in Patients With Tibiofemoral Osteoarthritis

Start date: June 21, 2011
Phase: N/A
Study type: Interventional

The main objective of the study was to demonstrate the non-inferiority of the efficacy of a single intra-articular injection of OSTENIL PLUS compared to that of a single intra-articular injection of the reference product SYNVISC-ONE in the treatment of symptomatic tibiofemoral osteoarthritis. The primary endpoint was the change in mean score on the WOMAC pain scales from D0 to D180.

NCT ID: NCT03201276 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Individual Differences in Glucosamine Sulfate Exposure Levels

Start date: July 2, 2017
Phase: N/A
Study type: Observational

Glucosamine is an important part of the treatment strategy for osteoarthritis, but its effectiveness is still controversial. To explain the efficacy differences of glucosamine, in this study the investigators detect the concentration of glucosamine in the plasma and synovial fluid, some effect indexes such as inflammatory markers and gene polymorphism of glucosamine transporters. On the one hand, the investigators compare the plasma peak and gluten glucosamine concentration and the concentration in synovial fluid among participants to observe the individual differences of glucosamine exposure in vivo. On the other hand, the investigators investigate the correlation between drug concentrations, effect index and gene polymorphism. The hypothesis is that glucosamine exposure in vivo has individual differences and gene polymorphism can explain this differences.

NCT ID: NCT03200288 Recruiting - Knee Osteoarthritis Clinical Trials

A Study to Evaluate the Clinical Performance and Safety of an Intra-articular Hyaluronic Acid in Knee Osteoarthritis

Start date: June 29, 2017
Phase: Phase 3
Study type: Interventional

This is a study to evaluate the Clinical Performance and Safety of a single intra-articular (i.a.) injection of hyaluronic acid product (as HL-01) in the treatment of pain due to osteoarthritis (OA) of the knee.