Clinical Trials Logo

Knee Osteoarthritis clinical trials

View clinical trials related to Knee Osteoarthritis.

Filter by:

NCT ID: NCT03527849 Recruiting - Knee Osteoarthritis Clinical Trials

Effects of Mindfulness-Based Stress Reduction on Knee Osteoarthritis

MBSR on KOA
Start date: January 30, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to see if stress reduction can lead to less pain due to knee osteoarthritis. To do this the investigators will compare two types of stress reduction modalities, Mindfulness-Based Stressed Reduction (MBSR) and a Health Enhancement Program (HEP). Both include stress reduction techniques, but MBSR has a mindfulness component that includes meditation. MBSR will be provided either in-person or online and HEP will be in-person. The assignment to the stress reduction program will be determined by the Principal Investigator. In order to assess for stress reduction and pain reduction the investigators will use validated measuring tools before, during, and after the course instructions.

NCT ID: NCT03509025 Active, not recruiting - Knee Osteoarthritis Clinical Trials

Follow-up Study for Participants Jointstem Clinical Trial

Start date: February 8, 2017
Phase: Phase 2
Study type: Interventional

This study is a long term follow-up study to investigate the safety of autologous transplantation of Adipose Tissue derived Mesenchymal stem cells (MSCs) in patient with Knee Osteoarthritis.

NCT ID: NCT03491761 Recruiting - Knee Osteoarthritis Clinical Trials

Intra-articular Platelet-Rich Plasma Compared With Viscosupplementation in the Treatment of Knee Osteoarthritis

Start date: April 21, 2017
Phase: Phase 2
Study type: Interventional

This is a single-center, prospective, randomized, single-blind, comparator therapy, parallel group study for symptomatic patients diagnosed with knee osteoarthritis. The aim is to demonstrate superior efficacy of platelet-rich plasma (PRP) as compared to hyaluronic acid (HA) in treating knee osteoarthritis. This aim will be objectively measured by endpoint consisting of changes in cartilage thickness from baseline in the MRI. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), total score at 12 months, will measure changes in pain and function from baseline. Approximately 100 subjects will be treated at NorthShore University HealthSystem as part of this study. This study has the potential to improve outcomes in a very common chronic degenerative disease, osteoarthritis, which can have a significant effect on individuals' quality of life.

NCT ID: NCT03491397 Not yet recruiting - Knee Osteoarthritis Clinical Trials

GAE for the Treatment of Knee Osteoarthritis

GAE-OA
Start date: June 1, 2018
Phase: N/A
Study type: Interventional

The purpose of this clinical research study is to examine whether Embozene treatment of the genicular artery is a safe and effective way to treat arthritic knee pain. Embozene is a medical device made by Boston Scientific approved in the United States for the treatment of hypervascular tumors and arteriovenous malformations. It consists of thousands of microscopic spheres that are injected into the artery in the knee going to the region of pain. One of the causes of pain in the setting of knee arthritis is increased blood flow going to the specific area of pain. The goal of this procedure is to decrease the blood flow (embolize) to the specific region of the knee that is causing your pain. This is done by infusing Embozene particles into the specific blood vessel (genicular artery) supplying the area of pain in the knee.

NCT ID: NCT03485157 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Micronized dHACM vs. Saline in the Treatment of Osteoarthritis of the Knee

Start date: March 2018
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine the safety and effectiveness of micronized dehydrated human amnion chorion membrane as compared to the 0.9% Sodium Chloride Injection, USP placebo control for the treatment of knee osteoarthritis

NCT ID: NCT03484091 Recruiting - Knee Osteoarthritis Clinical Trials

Comparison of Single Intra-articular Injection of Hyruan-One With Hylan G-F 20 in Knee Osteoarthritis

Start date: April 1, 2018
Phase: Phase 4
Study type: Interventional

We compare the efficacy of intra-articular injection of Hyruan-One with Hylan G-F 20 and placebo (NSS) controlled in a double-blind RCT.

NCT ID: NCT03477942 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Impact of Mesenchymal Stem Cells in Knee Osteoarthritis

Start date: May 2018
Phase: Phase 1
Study type: Interventional

Many patients with osteoarthritis of the knee fail non-operative measures and elect to have knee arthroplasty to improve their quality of life. If successful, intra-articular mesenchymal stem cell (MSC) injections into the knee may offer another viable non-operative treatment modality. Additionally, this modality may have reparative or regenerative potential, which could lead to the first treatment for osteoarthritis that treats the underlying disease as opposed to symptomatic control. Additionally, there are no acceptable non-surgical treatments for focal chondral defects of the knee. Surgical treatments that do exist have diminished outcomes if performed on patients older than age 30-40 years. If successful, intra-articular MSC injections into the knee would represent the first non-operative treatment for focal chondral defects and also represent a potential option for treatment in patients over the age of 30-40 years. This trial will be a prospective, single-center phase I pilot study to evaluate the safety and tolerability of a single intra-articular injection of autologous bone marrow-derived MSCs in 16 subjects, 8 who have knee osteoarthritis and 8 who have a focal chondral defect in the knee. Patients will undergo a bone marrow harvest procedure at the Dahms Clinical Research Unit (DCRU) of University Hospitals Cleveland Medical Center. MSCs will be isolated and expanded. After approximately 2-3 weeks, patients will return for an intra-articular injection of 50x106 MSCs Subsequent study visits will occur on post-injection day 7 and months 2, 6, 12, and 24. Safety of intra-articular injection of MSCs will be evaluated at study visits by interval history, physical examination and assessment of any adverse events that are observed/reported. Additionally, efficacy will be evaluated by having patients complete functional outcome measures including: Visual Analog Score (VAS) for pain, Knee Injury and Osteoarthritis Outcome Score (KOOS), International Knee Documentation Committee (IKDC) Subjective Knee Form, and Lysholm Knee Scale. These will be completed at the pre-treatment visit and then repeated at the 2, 6, 12, and 24-month follow-up visits. Lastly, T1 rho and T2 mapping on magnetic resonance imaging (MRI) will be used to assess for improved cartilage quality after intra-articular injection of MSCs. An MRI will be obtained at the pre-treatment visit. At the 12 and 24 month follow up visit, additional MRIs will be obtained and analyzed to compare the pre-treatment MRI to post-treatment MRIs.

NCT ID: NCT03473873 Recruiting - Knee Osteoarthritis Clinical Trials

Protective Role of Muscle Function for Early Features of Knee Osteoarthritis After Anterior Cruciate Ligament Injury

SHIELD
Start date: March 2018
Phase:
Study type: Observational

In this longitudinal prospective cohort study including young people with anterior cruciate ligament reconstruction (ACLR), the aims are to 1) study the association between different measures of muscle function and early future of knee osteoarthritis (OA) assessed as patient-reported pain, 2) monitor the patients' functional status, and early OA development over time, 3) explore potential associations between muscle function and features indicative of early radiographic OA measured with MRI, and early detection of OA in biomarker profiles, respectively. The main hypothesis is that knee extensor weakness predicts future symptomatic OA of the knee (KOOS pain).

NCT ID: NCT03472300 Not yet recruiting - Pain Clinical Trials

Prevalence of Self-disclosed Knee Trouble and Use of Treatments Among Elderly Individuals

Start date: June 2018
Phase:
Study type: Observational

Although knee pain is prevalent among community-dwelling older adults, little is known about how people in general handle their pain. We will conduct a survey to explore how knee pain affects people's lives and which treatments or self-management strategies they have chosen (or are being offered), and how these interact concerning pain reduction and maintenance of function.

NCT ID: NCT03460665 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Symptomatic Efficacy of Microparticle Arterial Embolization in Knee Osteoarthritis Resistant to Medical Treatment

EMBARGO
Start date: June 1, 2018
Phase: N/A
Study type: Interventional

The aim of this double-blind, randomized, single-center prospective study (patient and evaluator) is to evaluate the efficacy of arterial occlusion (embolization) of neovessels by microparticle versus placebo on pain in disabling knee osteoarthritis at 12 months.