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Knee Osteoarthritis clinical trials

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NCT ID: NCT05632783 Withdrawn - Knee Osteoarthritis Clinical Trials

TreatMent Of Knee osTeoarthritis wIth chONdroitin Sulfate - the OA MOTION Study

MOTION
Start date: December 2023
Phase: Phase 3
Study type: Interventional

The goal of this phase III study is to evaluate the efficacy, safety, and tolerability of chondroitin sulfate 800 mg oral tablets versus placebo in the treatment of subjects with pain due to knee OA (osteoarthritis). The further aims of the study are to evaluate the durability of the treatment effect (up to week 36) and to gain further long-term safety and efficacy data (up to 48 weeks). The primary outcome of interest will be the effect of chondroitin sulfate on pain in the index knee at week 24 compared to placebo. The effect of chondroitin sulfate in the index knee functionality and the patient global impression of changes at 24 weeks compared to placebo are included as key-secondary endpoints. An additional key secondary endpoint will assess the durability of the effect on pain compared to placebo at week 36. Several additional secondary endpoints are included to further support the beneficial effect of the treatment and the improvements in patient's quality of life (i.e., Western Ontario and McMaster Universities Arthritis Index -WOMAC- subscales and total scores at each study visits, changes in patient's quality of life, use of rescue medication etc.) other than the safety of the product.

NCT ID: NCT05482672 Withdrawn - Depression Clinical Trials

GetHealthy-OA: A Program to Improve Pain and Function for Patients With Knee Osteoarthritis, Obesity, and Depression

Start date: April 2023
Phase: Phase 2/Phase 3
Study type: Interventional

The investigators have previously identified knee osteoarthritis patients with the combination of depression and an unhealthy weight may be an increased risk of more rapid joint degeneration and worsening pain. The GetHealthy-OA program combines a mind-body program with the oral supplement fisetin to potentially reduce the risk for this population by treating psychosocial, mechanical, and inflammatory mechanisms of knee osteoarthritis. This randomized clinical trial will compare the GetHealthy-OA program to minimally-enhanced usual care plus an oral placebo.

NCT ID: NCT05461638 Withdrawn - Knee Osteoarthritis Clinical Trials

Kinematic Alignment vs Mechanical Alignment for Total Knee Arthroplasty

KA vs MA
Start date: January 5, 2020
Phase: N/A
Study type: Interventional

This is a prospective, randomized, single-blinded, multi-center trial comparing Kinematic Alignment vs Mechanical Alignment in TKA patients using patient reported outcomes, clinical and functional performance tests and radiographic analyses.

NCT ID: NCT05374330 Withdrawn - Knee Osteoarthritis Clinical Trials

Electroacupuncture Treatment for Those With End Stage Knee Osteoarthritis on a Total Knee Arthroplasty Waitlist

Start date: September 2023
Phase: N/A
Study type: Interventional

A 3-armed pilot randomized controlled trial: electroacupuncture, sham acupuncture and waitlist groups.

NCT ID: NCT05202847 Withdrawn - Knee Osteoarthritis Clinical Trials

Clinial Application of Park et al.(The Knee 27 (2020) 1577-1584)'s Study

Start date: December 7, 2022
Phase: N/A
Study type: Interventional

The goal of this study was to perform pulsed radiofrequency ablation with a modified target suggested in the cadaver study by Park et al. (The Knee 27 (2020) 1577-1584) on knee osteoarthritis patients, and to evaluate the effect of reducing the frequency of intravascular injection and reducing pain.

NCT ID: NCT04595890 Withdrawn - Knee Osteoarthritis Clinical Trials

Knee Injections for the Clinical Management of Knee OsteoArthritis

KICK-OA
Start date: September 1, 2022
Phase: N/A
Study type: Interventional

Knee osteoarthritis (OA) is an incurable disease that involves breakdown of the knee joint. This breakdown is often accompanied by knee pain and stiffness, which can limit a person's daily physical activity. Fortunately, there are treatments that may stop or slow the progression of knee OA. Bone marrow aspirate can be extracted and processed into autologous, nucleated cells, then injected back into the knee affected by OA. These cells provide important nutrients that can improve the health of the knee joint and alleviate the symptoms of knee OA. Therefore, the investigators are interested in determining whether an injection of autologous, nucleated cells can improve physical activity, pain and function in people who are diagnosed with knee OA. The investigators will recruit a total of 100 subjects for this study and examine changes in physical activity using a research-grade Actigraph Monitor.

NCT ID: NCT04412837 Withdrawn - Osteoarthritis Clinical Trials

The Use of Cannabinoid Patch for Knee Osteoarthritis

Start date: October 2022
Phase: Phase 2
Study type: Interventional

This randomized, double-blind 2-arm parallel group study to determine the efficacy of a cannabinoid (CBD) patch on reducing pain in patients with knee osteoarthritis.

NCT ID: NCT04189640 Withdrawn - Knee Osteoarthritis Clinical Trials

Ultrasound-Guided Adductor Canal Block for Total Knee Arthroplasty Surgery

Start date: January 10, 2020
Phase: N/A
Study type: Interventional

The ultrasound-guided selective blockade of the saphenous nerve in the adductor canal provides effective analgesia and reduces postoperative pain in patients undergoing arthroscopic medial meniscectomy. Selective blockade of the saphenous nerve in the adductor canal provides effective analgesia without quadriceps muscle weakness. It has been shown that the adductor canal block (ACB) block increases the spread of local anesthetics in a distal and proximal way. Therefore, the proximal spread of local anesthetics may cause possible quadriceps weakness. The distal spread of local anesthetics may increase analgesic effect via sciatic nerve. The different volumes for ACB is a topic of discussion. The aim of this study is to compare the different volumes of US-guided ACB performing for postoperative analgesia management after total knee arthroplasty surgery.

NCT ID: NCT03975101 Withdrawn - Knee Osteoarthritis Clinical Trials

Very Small Embryonic-like Stem Cells for Knee Osteoarthritis

Start date: July 5, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

The aim of this study is the safety and efficacy of autologous very small embryonic-like stem cells(VSELs) to knee osteoarthritis.

NCT ID: NCT03936192 Withdrawn - Knee Osteoarthritis Clinical Trials

A Parallel-group Active Comparator, Double-blind, Multicenter, Randomized, Double-blind, Phase III Clinical Study

SAVE
Start date: January 2019
Phase: Phase 3
Study type: Interventional

A multicenter, randomized, double-blind, parallel-group, placebo-controlled, and active-drug, 12-week, multicenter clinical study. Participants will be randomized 2: 2: 1 to receive the combination of glucosamine sulfate + meloxicam (experimental group), combination of glucosamine sulfate + chondroitin sulfate (active control group) or placebo.