HIV Infection Clinical Trial
Official title:
Prognosis After Acute Coronary Syndrome in HIV-infected Patients
Objectives: Evaluate differences for mortality, morbidity and the cardiovascular risk factors between HIV and non-HIV patients with an acute coronary syndromes (ACS) after a 3-years follow up.
Background: There have been many cases of myocardial infarction reported in HIV-infected
young adults treated with HAART. Little is known to date, concerning the outcome and
prognostic factors of patients with acute coronary syndrome and HIV-infection.
Methods: Prospective cohort study to compare the evolution and prognosis between HIV and
non-HIV patients with an ACS.
Duration of the study: Two years for including patients. Three years of follow-up 100
HIV-patients with ACS and 200 non-HIV patients with ACS will be included in the study. All
patients will be included in the study from 30 Intensive Care Unit of Cardiology departments
in France.
Results: To compare the incidence of total mortality, cardiovascular mortality (myocardial
infarction, sudden death, cardiogenic shock, fatal stroke), morbidity (non fatal myocardial
infarction, unstable angina, recurrence of ischemia, cardiac failure, non fatal stroke) and
revascularization (percutaneous coronary intervention, coronary artery bypass graft surgery)
during a 3-year follow-up between HIV and non-HIV patients with ACS. Univariate and
multivariate analysis of predictive factors for cardiovascular events will be done.
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Observational Model: Case Control, Time Perspective: Prospective
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