View clinical trials related to Fatigue.
Filter by:When receiving adjuvant chemotherapy, a variety of symptoms will appear and it is very painful. These symptoms occur at the same time and are related to each other. The symptom distress may affect the patient's compliance with adjuvant chemotherapy and whether the adjuvant chemotherapy can be completed on schedule. Among the symptoms of trouble, cancer-related fatigue is the most common, and the incidence can be as high as 99%. In this study, I want to track the population of breast cancer patients receiving adjuvant chemotherapy, and women in the control group who receive only anti-hormonal breast cancer or carcinoma in situ. During the treatment period, at different time points, it also collects subjective symptom distress changes and changes. The study aimed cancer-related exhaustion is measured to gain a deeper understanding of the effects of symptom troubles suffered by patients during treatment. We also hoped that in the future, it can be provided to colleagues in clinical work and can be given to breast cancer patients receiving adjuvant chemotherapy and increased holistic care quality.
Among healthcare providers, nursing is a stressful and compassionate profession. Nurses empathetically support patients with pain, loneliness, disease and even confronted with death in line with their critically physical, mental, emotional, and spiritual needs and provide comfort, help, presence for them. Because nurses are frequently exposed to highly stressful and emotional situations, they suffer compassion fatigue (CF) over time under repeated exposures. CF will have a series of physiological, social, emotional, spiritual, and cognitive effects on nurses, threatening the existential integrity of them. The effects include high rates of anxiety and depressive disorders, decreased productivity, increased clinical errors, decreased quality of care and level of job satisfaction. Therefore, it is particularly important to pay attention to compassion fatigue to maintain mental health of nurses. Compassion fatigue refers to that in the process of providing assistance, the helper bears the pain of the recipient due to empathy, which reduces the helper's own energy or interest.Based on a widespread conceptual model, CF consists of two constructs: burnout and secondary traumatic stress. Nurses are at a great risk of compassion fatigue. CF is gradually becoming a serious problem which can affect nurses' physical and psychological health, performance, job satisfaction and quality of care . Thus, investigating the prevalence of CF among nurses and its related factors are warranted to prevent CF among nursing population. Research has studied the influencing factors of CF. Some studies have found that the demographic characteristics, worked related factors , the degree of exposure to traumatic events and psychological factors are important factors affecting nurses' compassion fatigue. Some studies suggest that resilience, social support, sense of control and meaningful recognition are negatively correlated with CF . Among them, resilience and self-efficacy are considered as important psychological factors affecting the individual's mental health, and they play an important role in the occurrence of CF. The working pressure of clinical nurses comes from the situations that they are exposed to patients' traumatic events and give excessive empathy for a long-term. CF among nurses is an undesirable outcome caused by maladaptation to this pressure. What's more, resilience, and self-efficacy play an important role in individual coping and psychological adjustment in face of stressful events. Therefore, it is necessary to explore the roles of resilience and self-efficacy in the process of CF. According to the theoretical path analysis of professional caregivers' quality of life, work environment, client environment and person environment factors have an influence on the development of compassion fatigue . Regarding to the psychological stress system , When confronted with stressful events, the individuals will have a stress response as a joint result of environmental factors and personnel factors. Thus, in accordance with the above two theories, being exposed to traumatic events is considered as a stressor, which could lead to CF. During this process, several external factors (work-related environmental factors) and internal factors (personality, social support) have effects on CF. In this study, resilience, and self-efficacy will be recognized as individual psychological characteristics and CF will be treated as a psychological change. Although there have been several studies on the predictors of CF in nurses around the world, limited knowledge exists in considering both internal factors (resilience and self-efficacy) and external predictive factors (demographic, work-related factors) of CF among nurses, especially in mainland China. The study aims to investigate the level of compassion fatigue among Chinese nurses and test the influences of demographic characteristics, work-related factors, resilience, and self-efficacy on compassion fatigue.
Depression is a major public concern associated with profound distress, intense suffering, and impairment in social, professional and familial functioning. Among the numerous symptoms defining depression, fatigue and motivation are not only frequent but also highly associated with poor quality of life and resistance to conventional antidepressant. Recent data, mainly obtained in animals, suggest that these symptoms may be linked to inflammatory processes within the central nervous system. Yet access to the brain is too invasive for exploring this link in patients with psychiatric conditions. However, certain conditions in neurosurgery, such as aneurysm rupture, require external evacuation, over several days or weeks, of the fluid bathing the brain through a catheter directly inserted into it. Critically, these patients also exhibit extreme exhaustion and fluctuating motivation, allowing to investigate the involvement of neuroinflammation in lack of motivation and fatigue by carrying out repeated motivation assessments with short behavioral tests (around ten minutes), while performing an analysis of inflammation markers in the fluid evacuated from the brain. The identification of inflammatory mechanisms underlying lack of motivation and fatigue could lead to the development of treatments for both resistant depression and motivation deficits that largely hamper rehabilitation in neurosurgery.
A typical tennis match can take 1 to 5 hours. Tennis serve can be divided into eight stages and three phases. Injuries usually happen in the cocking stage and acceleration phase of the serve, where it requires large shoulder range of motion and proper scapular motion, including sufficient scapular upper rotation, external rotation, and posterior tilt to produce a powerful serve. Altered shoulder kinematics are associated with shoulder injuries in tennis players, including delayed shoulder horizontal adduction, and early external rotation. Due to the long duration and repetition of activity in a match, fatigue may happen and result in decreases in sensory input, passive range of motion, ball speed, and muscle strength. These changes may further lead to altered glenohumeral and scapular kinematics. However, previous studies mainly focused on the effects of fatigue on scapular kinematics in constrain movements and applied different fatigue protocols, which lead to inconsistent results. Tennis serve in cocking stage and the acceleration phase require high activation of shoulder external rotators and internal rotators, including infraspinatus, pectoralis major, subscapularis, latissimus dorsi and serratus anterior. However, to our knowledge, no study has investigated how fatigue of shoulder rotators influences shoulder kinematic as well as scapular kinematics during the late cocking stage and acceleration phase of tennis serve. Therefore, the investigators aim to investigate whether fatigue of shoulder rotator affects shoulder kinematics in healthy tennis players during the late cocking stage and acceleration phase of tennis serve.This is a single group, pretest-posttest measurement study. In a fatigue protocol, investigators use an isokinetic dynamometer to induce fatigue of shoulder rotators. Outcome measures will be tested before and after the fatigue protocol, including peak torque of shoulder rotators, humerothoracic kinematics, scapulothoracic kinematics, and median power frequency recorded by a surface electromyography. Peak torque of shoulder rotators will be measured with an isokinetic dynamometer. Surface electromyography will be used to measure peripheral muscle fatigue by maximum voluntary isometric contraction. Humerothoracic kinematics and scapulothoracic kinematics during a functional tennis serve and scaption will be collected with a motion capture system.
To gain a comprehensive understanding of the biomechanical behaviour of human heart to explore the concept of myocardial fatigue in response to a temporal range of preload, afterload and drug-induced inotropy using in-vitro contractile assays.
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterised by destruction of the intrahepatic bile ducts leading to liver inflammation and fibrosis, and ultimately liver cirrhosis and end-stage liver disease. More than 50% of patients with PBC suffer from chronic fatigue, and approximately 20% suffer from severe fatigue with negative impact on their quality of life. Although fatigue is a large problem in patients with PBC, no effective treatments are available. A Danish intervention study have shown that high dose oral thiamine (Vitamin B1) were effective in treating chronic fatigue in patients with inflammatory bowel disease. In this study, only few and minor adverse events to thiamine treatment were observed. Although the precise mechanism of work remains unknown, the investigators see no reason that this cannot be transferred topatients with PBC. Hence, the investigators aim to conduct a study investigating the use of oral thiamine in chronic fatigued patients with PBC. The study will be conducted as a double-blinded, placebo-controlled, randomised, crossover trial including 36 patients with PBC and with a higher fatigue level than in the general population for more than six months. The patients will be randomised into one of two 3x4 weeks setups; 1) thiamine for four weeks followed by four weeks washout and finally four weeks of placebo or 2) placebo for four weeks followed by four weeks washout and finally four weeks of thiamine. The primary endpoint is to investigate the fatigue-level before and after treatment with thiamine and placebo using every patient as their own control. Fatigue-level will be measured using international validated questionnaires. The doses of thiamine are calculated based on the patient gender and weight. All patients will be included in the outpatient clinic at the Department of Hepatology and Gastroenterology at Aarhus University Hospital.
The objective of this study is to carry out a randomized clinical trial with healthcare workers in Mexico through a web platform. The intervention aims to reduce anxiety, depressive symptoms, burnout, stress, compassion fatigue, and increase the quality of life and sleep and self-care, as well as improve skills in providing bad news to patients and their families. A self-applied intervention will be compared with an intervention delivered by therapists providing the same intervention implemented through Zoom, Skype, or Microsoft Teams, to ensure sanitary protection measures.
The purpose of this study is to evaluate an educational professional development program designed to assist health care professionals in developing self-awareness and self-care choices as a means to avoid compassion fatigue and improve resilience.
Mask wearing during the Covid-19 pandemic has been proven substantially effective in containing the spread of infection, with cloth masks being the most universally used. However, cloth masks may be uncomfortable and have physiological repercussion during exercise. This study aims to investigate the impact of cloth masks during exercise.
Overloading is a key training principle used by athletes and coaches to improve physical performance. Intensified training periods are therefore commonly incorporated into the course of a regular training season. From a clinical point of view, very intense periods of training are associated with a temporary immunological deficiency which can lead to teh "overreaching syndroms". During periods of overreaching, nutritional strategies are mainly aimed at ensuring sufficient amounts of energy to support the increase in effort. However less is known about nutritional supplements to attenuated the inflammatory/immunological response to training stress. Probiotic bacteria are defined as live food ingredients beneficial to the host's health. Numerous health benefits have been attributed to probiotics, including effects on gastrointestinal tract function and disease, immune function, hyperlipidemia, hypertension, and allergic conditions. Studies in the literature on the ergogenic effect of probiotics in athletes are still scarce today. this study aims to explore the potential role of probiotics on performance, recovery from fatigue and immune function during intensive period of training.