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Fatigue clinical trials

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NCT ID: NCT03809130 Not yet recruiting - Malignant Neoplasm Clinical Trials

Untire Application Intervention in Reducing Cancer-Related Fatigue in Cancer Patients and Survivors

Start date: March 31, 2019
Phase: N/A
Study type: Interventional

This trial studies how well Untire application intervention works in reducing cancer-related fatigue in cancer patients and survivors.The Untire application focuses on themes that have been identified as causing or contributing to cancer-related fatigue. It may provide information and tips to improve lifestyle, give exercises for body and mind to increase energy levels, offer weekly reports to measure progress, and offer access to an online support community.

NCT ID: NCT03807973 Not yet recruiting - Healthy Clinical Trials

Tracking Peripheral Immune Cell Infiltration of the Brain in Central Inflammatory Disorders Using [Zr-89]Oxinate-4-labeled Leukocytes.

Start date: March 4, 2019
Phase: Phase 1
Study type: Interventional

This study will use brain PET/MRI and an investigational radioactive drug called [Zr-89]oxine to track the location of white blood cells in the body. PET/MRI will be used to visualize labeled white blood cells and determine if they enter the central nervous system in conditions associated with brain inflammation (also called neuroinflammation). By better understanding the roleneuroinflammation in fibromyalgia, chronic fatigue syndrome, and multiple sclerosis, we hope to be able to better diagnose and treat patients in the future.

NCT ID: NCT03803956 Not yet recruiting - Clinical trials for Muscle; Fatigue, Heart

Infrared Low-level Laser Therapy Before Intense Progressive Running Test of High-level Soccer Players

Start date: January 16, 2019
Phase: N/A
Study type: Interventional

Photobiomodulation therapy (PBMT) has recently been used to alleviate postexercise muscle fatigue and enhance muscle recovery, demonstrating positive results. A previous study by the investigator's research group demonstrated the optimal dose and the optimal output power (100 mW) for an infrared wavelength (810 nm). However, the effects of optimized PBMT on performance and post-exercise recovery in high-level soccer players, to date have not been evaluated. The present research project aims to evaluate the effects of PBMT (using low-level laser therapy) applied before a progressive running test on functional, muscle damage, inflammatory and oxidative stress markers in high-level soccer players.

NCT ID: NCT03800342 Recruiting - Fatigue Clinical Trials

Recovery, Fatigability, and Proteomic Response to Aerobic Exercise Training in Healthy Individuals

Start date: January 2019
Phase: N/A
Study type: Interventional

The purpose of this protocol is to investigate the role of expired non-metabolic carbon dioxide in the relationship between fatigability and recovery and the response to aerobic exercise training in healthy individuals. Both fatigability and recovery are profoundly influenced by mitochondrial energetics which can be inhibited by ionic by-product accumulation during exercise. Buffering mechanisms of these fatigue-inducing ions releases non-metabolic carbon dioxide (CO2) that can be measured as expired CO2 (VCO2) during cardiopulmonary exercise testing (CPET), however the role of non-metabolic VCO2 in the relationship between fatigability and recovery has yet to be investigated. Furthermore, this study aims to identify the how the patterns of proteins in healthy individuals respond to aerobic exercise training (e.g. stationary cycling) over approximately one month. The underlying mechanisms of recovery after physical activity, including mechanisms or biological pathways that could be highlighted by analysis of proteins in urine, could add to scientific knowledge regarding physical activity tolerance and potential exercise interventions. This knowledge could eventually assist with designing precise and personalized exercise interventions to improve physical activity performance. The investigators hypothesize that 1) non-metabolic CO2 will be at least moderately associated with the inverse relationship between fatigability and recovery; and 2) highly active adults, compared to sedentary individuals, will exhibit differential proteomic patterns in response to an initial acute bout and subsequent repeated bouts of aerobic exercise.

NCT ID: NCT03799887 Completed - Parkinson Disease Clinical Trials

Effects of Different Percentages Body Weight Supported Treadmill Training on Gait, Balance, Quality of Life and Fatigue in Parkinson's Disease

Start date: October 20, 2010
Phase: N/A
Study type: Interventional

Body weight supported treadmill training (BWSTT) is an important rehabilitative choice for neurologically impaired subjects such as Parkinson's disease (PD). The aim of the study is to evaluate the effectiveness of different percentages BWSTT on gait, balance, quality of life and fatigue in moderate to advanced PD.

NCT ID: NCT03794947 Not yet recruiting - Fatigue Clinical Trials

Remote Ischaemic Conditioning for Fatigue After Stroke

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

This is a pilot randomised control trial to assess the safety, compliance, and acceptability of delivering a 6-week programme of remote ischaemic conditioning (RIC) to stroke patients suffering with fatigue, and study feasibility. A minimum of 34 patients who have suffered an ischeamic or haemorrhagic stroke and who suffer from fatigue, will be recruited and randomised to receive a 6-week programme of either RIC or a sham intervention.

NCT ID: NCT03789188 Not yet recruiting - Fatigue Clinical Trials

Characterizing Fatigue Experienced by Registered Nurses

Start date: January 23, 2019
Study type: Observational

Background: Nursing is a high-stress job. It can be physically and mentally taxing. Nurses can have health problems due to long work hours, stressful work environments, and shift work. Fatigue is common among registered nurses (RNs). It has been linked with job burnout, missing work, injuries at work, and reduced job performance. Fatigue in RNs has been studied, but researchers want to learn more about it. Objectives: To learn more about how fatigue affects registered nurses. Eligibility: RNs at least 18 years old who work at NIH Design: Part 1: All RNs at the NIH will be invited to participate in an anonymous online survey. They will answer questions about their jobs and fatigue. Part 2: Fatigue levels in a small group of RNs will be evaluated more closely. They will be screened with questions by phone or in person. They will be asked about their work schedule, ability to speak and read English, and general health. Participants in Part 2 of the study will have 3 study visits. -Visit 1 will be at least 48 hours after the last time the participant worked. Participants will fast before the visit. They will have a medical history, physical exam, and blood tests. They will receive a food diary and a sleep watch and diary. They will wear the watch and complete the diaries for 1 week. Participants will answer questions on an iPad 2 times a day for 4 days. The first day will be when they complete visit 1. They then will do this for 3 workdays in a row. This will be right before and after work on those days. Questions will test their thinking and ask about their feelings. - Visit 2 will be right after finishing 3 work days in a row. Participants will have blood pressure and blood samples taken. - Visit 3 will be 1 week after finishing the diaries. Participants will return the sleep watch, iPad, and diaries A dietician may ask them questions about the food diary.

NCT ID: NCT03786640 Not yet recruiting - Fatigue Clinical Trials

Abbott Brady 3T MRI PMCF

Start date: May 2019
Study type: Observational

The objective of this post-market, clinical follow up (PMCF) study, is to confirm the long-term safety of the Tendril STS and Isoflex leads, implanted with the Assurity MRI™ or Endurity MRI™ pacemakers, in patients undergoing a clinically indicated 3T MRI scan.

NCT ID: NCT03775902 Recruiting - Clinical trials for Type 2 Diabetes Mellitus

Regulation of KATP Channels and Na+/K+ ATPase in Relation to Fatigue Development

Start date: December 19, 2018
Phase: N/A
Study type: Interventional

To investigate the role of ATP sensitive K+ potassium channels and the Na+/K+ pump in the development of fatigue in healthy and in pre/diabetic subjects.

NCT ID: NCT03773003 Not yet recruiting - Clinical trials for Fatigue Syndrome, Chronic

Research for Pathophysiology of Cancer Related Fatigue (CRF) and Chronic Fatigue (CFS/ME)

Start date: April 1, 2019
Phase: N/A
Study type: Interventional

Research for Pathophysiology of Cancer Related Fatigue (CRF) and Chronic Fatigue Syndrome (CFS/ME) by Lipidomics, Metabolomics, Intestinal and Peritoneal Microbiome Analysis and Exome Analysis and Investigation of a Possible Benefit of Probiotics.