Diabetes Clinical Trial
Official title:
A Pilot Study of the Changes in Inflammatory State in Asian Americans Changing From Traditional Asian Diet to Typical American Diets
We hypothesize that Asian Americans compared to Caucasians, will be at higher risk of
developing a pro-inflammatory state that may contribute to the development of heart disease
and diabetes when they change from a traditional Asian diet to a typical Western diet. These
inflammatory responses will be reflected by the activation of monocytes as measured by
protein kinase C (PKC), a known activator of monocytes.
We also hypothesize that the changes of these inflammatory responses in the gingival
crevicular fluid (GCF) will reflect similar changes of these markers in the plasma and
monocytes.
Specific aims:
1. To compare the inflammatory responses (primarily PKC activation in monocytes), between
Far-East Asian Americans and Caucasian Americans, when they change from a traditional
Asian diet to a typical American diet.
2. To correlate the biochemical changes of inflammatory responses in the plasma and
monocytes with those in the gingival crevicular fluid (GCF).
n/a
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