Fatigue, Depressive Disorders and Insomnia in Adult Patients With Marfan Syndrome and Ehlers-Danlos Syndrome: Survey — FAMED  

Depression Clinical Trial

Official title: Observational Survey on Fatigue Levels in Relation to Depressive Disorders and Insomnia in Adult Patients With Marfan Syndrome and Ehlers-Danlos Syndrome

Status Completed

Clinical Trial Summary

The goal of this observational study is to describe and assess the presence of perceived fatigue in subjects with MFS and EDS. the main question it aims to answer through the FSS instrument is:

• The relationship of fatigue with physical and psychological characteristics, the presence of depressive disorders and insomnia.

Clinical Trial Description

Marfan syndrome (MFS) and Ehlers-Danlos Syndrome (EDS) are rare diseases of the connective tissue presenting peculiar symptoms as well as high mortality due to complications related to dilatation and dissection of the ascending aorta and great arteries. Life expectancy of patients with MFS and EDS has improved markedly in the last decades, but still remains lower than that of the general population. Fatigue represent one of the main causes that limit the quality of life in these populations. The Fatigue Severity Scale (FSS) is a questionnaire widely used in populations with chronic diseases and has been previously applied in MFS and EDS population: indeed, fatigue interferes with activities of daily living and the presence of chronic pain. However, the potential correlations that fatigue may have with different aspects of psychological well-being (i.e. insomnia and depression) were not investigated in MFS and EDS. ;

Related Conditions & MeSH terms

• Depression
• Depressive Disorder
• Ehlers-Danlos Syndrome
• Fatigue
• Insomnia
• Marfan Syndrome
• Rare Diseases
• Sleep Initiation and Maintenance Disorders
• Syndrome

• NCT number: NCT05712564
• Study type: Observational
• Source: IRCCS Policlinico S. Donato
• Status: Completed
• Start date: January 9, 2023
• Completion date: May 9, 2023