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Dementia clinical trials

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NCT ID: NCT05543681 Recruiting - Depression Clinical Trials

IGC-AD1 Trial on Agitation in Dementia Due to Alzheimer's

IGC-AD1-P2
Start date: October 11, 2022
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the efficacy of an oral medication, IGC-AD1 that is a natural THC-based (Tetrahydrocannabinol) formulation, administered in micro doses, twice a day, on symptomatological Agitation, in patients with mild to severe dementia from Alzheimer's.

NCT ID: NCT05536830 Active, not recruiting - Dementia Clinical Trials

Assessment of DeMentia Nutrition Intervention Needs Among Care Recipients and carEgivers

ADMIRE
Start date: October 25, 2022
Phase:
Study type: Observational

Nutrition is critical for disease prevention and brain health. Malnutrition and weight loss often affect persons with Alzheimer's dementia (PWD), worsening overall health and dementia. Informal caregivers (usually family members) perform many nutrition-related tasks as part of daily care such as food preparation and feeding. Limited research, however, suggests informal caregivers experience high rates of caregiver burden, malnutrition and low health literacy. More research is needed to uncover these and other factors that may contribute to malnutrition for both PWDs and their caregivers. Nutrition literacy, or ability to navigate nutrition information to select healthy food, may be an important caregiving factor that protects both individuals from experiencing nutritional decline. Although the NIH has increased funding to support caregiver research, caregiver interventions that include nutrition are lacking. The purpose of this study is to inform the design of a future nutrition intervention study.

NCT ID: NCT05535790 Not yet recruiting - Dementia Clinical Trials

Effect of Circadian Light on Hospitalized Persons With Dementia and Older Adults With Cognitive Impairments.

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

Light stimulates the human visual system and the biological functions in the retina, also referred to as non-visual responses, e.g. hormone production. Exposure to the correct light composition can produce acute alertness and increase good sleep quality (1). In this study, subjects will be exposed to 24-hour LED naturalistic lighting (intervention) or traditional lighting (control) during all days of hospitalization. Subjects will be blinded to the intervention as they will not be told if they are admitted to an intervention patient room or a control patient room. The primary outcome measure is cortisol levels measured in saliva samples. Secondary outcome measures are delirium rates, length of admission, use of constant observation, mortality and adverse advent. It is estimated that 80 subjects will be included in the study.

NCT ID: NCT05535478 Enrolling by invitation - Diabetes Clinical Trials

Deprescribing of Diabetes Regimens in Long Term Care Residents With Alzheimer's

Start date: January 31, 2023
Phase: N/A
Study type: Interventional

Objectives To 1) examine the ability of the STRIDE (Simplification of Treatment Regimens and Individualized Diabetes Education) educational program to increase deprescribing of high hypoglycemia risk glucose-lowering medications (HRMs) among long term care facility (LTCF) residents with ADRD, 2) assess key implementation constructs (secondary outcomes) of the STRIDE program, including acceptability, appropriateness, and feasibility, and 3) validate the primary HRM use outcome measure.

NCT ID: NCT05534958 Recruiting - Clinical trials for Mild Cognitive Impairment and Dementia

UK Validation of the Automated "AcceXible" Speech Analysis Software

Start date: August 1, 2022
Phase:
Study type: Observational

Dementia, especially dementia caused by Alzheimer's disease, is considered one of the most severe health problems of our time. It is currently known that the disease begins many years before clinical symptoms appear. The sooner the patient is diagnosed, the sooner the patient will be in a position to prevent further deterioration. A recent orientation is the analysis of language in relation to the description of images with a high and varied semantic and emotional content. It can be studied that changes in the description of an image check if these changes are associated with the evolution of a person with probable impairment both in memory and cognitive as well as emotional, psychiatric, behavioral and even in their interaction with environmental factors especially those associated with socialization and loneliness. The present study has the objective of validating a digital method for detection and follow-up of patients with mild cognitive impairment (MCI) or dementia in a memory clinic setting.

NCT ID: NCT05532657 Enrolling by invitation - Aging Clinical Trials

ACHIEVE Brain Health Follow-Up Study

ACHIEVE-BHFU
Start date: January 12, 2023
Phase: Phase 3
Study type: Interventional

The ACHIEVE Brain Health Follow-Up Study is a 3-year follow-up to the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) randomized study to determine the long-term effect of hearing intervention vs. successful aging/delayed hearing intervention on rates of cognitive decline and incident mild cognitive impairment or dementia.

NCT ID: NCT05531591 Active, not recruiting - Depression Clinical Trials

RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT)

ONR
Start date: August 1, 2019
Phase: Phase 4
Study type: Interventional

The purpose of this study is to assess which antidepressants work the best in older adults who have treatment-resistant depression (TRD), and to test whether treatment-resistant late life depression is associated with declines in memory and attention and brain structure and function.

NCT ID: NCT05530590 Recruiting - Alzheimer Disease Clinical Trials

Minnesota Inclusive LTSS for LGBTQ Seniors

MILLS
Start date: January 31, 2024
Phase: N/A
Study type: Interventional

This study is designed to help improve the care of sexual and gender minority (SGM) with Alzheimer's Disease and Alzheimer's Disease Related Dementia (AD/ADRD) in long-term services and supports (LTSS) by training the state's LTSS workforce in SGM culturally responsive care. The randomized controlled trial will rigorously test the effects of an in person versus an online training program on improving SGM culturally responsive care with a waitlist control.

NCT ID: NCT05529706 Recruiting - Alzheimer Disease Clinical Trials

Community-based Brain Health Program to Address Dementia Risk

C-BBHP
Start date: April 24, 2023
Phase: N/A
Study type: Interventional

This is a validation study to evaluate the acceptability, feasibility and preliminary efficacy of the Brain Health Program, a multimodal curriculum covering dementia risk factors and evidence-based change interventions. The goal of this study is to evaluate the Brain Health Program in individuals with identified risk factors for the onset of dementia and to prepare for a large-scale efficacy trial in this population.

NCT ID: NCT05529277 Active, not recruiting - Dementia Clinical Trials

Implementing Dementia Care Management Into Routine Care in the Region Siegen-Wittgenstein

RoutineDeCM
Start date: September 1, 2022
Phase:
Study type: Observational

Dementia Care Management (DeCM) is an evidence-based model of care in Germany. It has proven its efficacy and cost-effectiveness. However it has not been implemented into routine care so far. The aim of this trial is to implement Dementia Care Management into routine care in a selected region in Germany and evaluate the process of implementation as well as the effect of Dementia Care Management on participants. Recruited in regular routine care n=60 people with cognitive impairment and/ or their cares will receive Dementia Care Management provided by specifically trained and qualified dementia care managers for 6 months. Data will be assessed and analysed prior to the implementation, immediately after having received the intervention and at a later time point. The effect of the intervention on person-oriented health care outcomes wil be analysed as well as factors associated with that.