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Dementia clinical trials

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NCT ID: NCT05043441 Not yet recruiting - Clinical trials for Psychological Distress

A Ten-Week Online Acceptance and Commitment Therapy Intervention for Family Caregivers of People With Dementia

Start date: February 21, 2022
Phase: N/A
Study type: Interventional

The randomized controlled trial aims to assess effects of a coach-guided ten-week online acceptance and commitment therapy (ACT) intervention on distressed family caregivers of people with dementia (PwD) compared to the control group. A total of 64 family caregivers of PwD who meet the inclusion criteria will be recruited and randomized to either the intervention group or the control group. Exploratory hypotheses are that the ACT group will show decreases in caregivers' psychological distress and burden and improvements in psychological quality of life and engagement in meaningful activities at posttest and 3-month follow-up, compared to the control group.

NCT ID: NCT05040321 Not yet recruiting - Dementia Clinical Trials

Sirtuin-NAD+ Activator in Alzheimer's Disease

Start date: October 1, 2021
Phase: Phase 1/Phase 2
Study type: Interventional

The primary objectives are to: 1. To determine whether βNMN, after its daily oral administration, penetrates the blood-brain barrier in humans by measuring the cerebrospinal fluid (CSF) concentrations of βNMN and its key metabolites, nicotinamide (NAM), NR, 2-PY, and MeNAM at baseline and on day 90 at steady state. 2. To evaluate whether oral βNMN administration engages the sirtuin-NAD+ pathway by determining the abundance of NAD+ (a SIRT1 substrate) in the brain using ultra-high field 7T magnetic resonance spectroscopy and in peripheral blood mononuclear cells using a validated LC-MS/MS assay. 3. To determine whether βNMN alters the circulating biomarkers of aging that the geroscience experts have recommended (HbA1C, IGF1, T3, IL6, TNF, and urinary F2-isoprostane).

NCT ID: NCT05038579 Completed - Dementia Clinical Trials

Clinical Validation of a Cognitive Stimulation Platform for Individuals With Dementia - Musiquence

Start date: September 1, 2019
Phase: N/A
Study type: Interventional

Dementia is a neurodegenerative syndrome that leads to cognitive deficits and, consequently, affects functionality and quality of life. This study will explore the clinical impact of a customized cognitive stimulation program, using Musiquence.

NCT ID: NCT05034107 Recruiting - Dementia Clinical Trials

Effects of Diffused Ylang-Ylang Essential Oil Amongst Older Persons With Dementia

Start date: June 30, 2021
Phase: N/A
Study type: Interventional

Ylang-Ylang (Cananga Odorata) essential oil has been postulated to have calming effect, which may improve BPSD in persons with dementia. This study aims to examine dementia-related behavioural changes using established assessment tools and brain derived neurotropic factor (BDNF) in persons with BPSD.

NCT ID: NCT05033262 Completed - Alzheimer Disease Clinical Trials

Our Care Wishes - Dementia

Start date: October 7, 2020
Phase: N/A
Study type: Interventional

This Our Care Wishes- Dementia pilot study is adapting an existing successful online advance care planning platform to the specific needs of persons living with dementia and shared decision-makers (SDMs) and testing the usability and acceptability among nursing home residents and SDMs.

NCT ID: NCT05032664 Recruiting - Clinical trials for Behavioural and Psychiatric Symptoms of Dementia

Effectiveness of Home-based Aromatherapy for BPSD

Start date: August 18, 2021
Phase: N/A
Study type: Interventional

Behavioral and psychological symptoms of dementia (BPSD) is the most prominent and distressing manifestation for older persons with dementia (PWD) and caregivers. Aromatherapy was a potentially safe and effective non-pharmacological strategy in BPSD management and could provide benefits to PWD and caregivers. In Hong Kong, some Residential Care Homes for the Elderly and day care centres have provided aromatherapy service to the PWD receiving service from them. However, no such service was provided to the community-dwelling PWD living at home, which constitute a larger proportion of dementia population in HK. In addition, there is no clear implementation protocol, or formal training to the family caregivers to deliver aromatherapy to PWD in home-based setting. Therefore, this study aims to develop and evaluate the effectiveness of a home-based family caregiver-delivered aromatherapy programme for the management of BPSD. PWD ≥ 60-year-old, with BPSD symptoms, and living at home, as well as their family caregivers will be recruited. Participants who pass the screening are randomly allocated to intervention or control group. Those in the intervention group receive home-based aromatherapy programme. Those in the control group receive no intervention for 3-week control period, and then receive home-based aromatherapy programme. The outcome measures will be conducted at baseline and after the 3-week intervention/control period by using Chinese versions of Neuropsychiatric Inventory (CNPI), Chinese version of Dementia QoL Measure-Proxy (C-DEMQoL-Proxy), and Chinese version of Zarit Burden Interview (CZBI).

NCT ID: NCT05023564 Recruiting - Dementia Clinical Trials

PUMCH Dementia Longitudinal Cohort Study

Start date: December 1, 2020
Study type: Observational

The PUMCH Dementia Cohort is a hospital-based, observational study of Chinese elderly with cognitive impairment.

NCT ID: NCT05014971 Not yet recruiting - Lewy Body Disease Clinical Trials

Telehealth in Lewy Body Dementia

Start date: September 1, 2021
Phase: N/A
Study type: Interventional

Lewy body dementia (LBD) is the 2nd most common neurodegenerative dementia in the US. Optimal care requires an interdisciplinary approach, however often faced barriers include rural residence, limited access to specialists, travel distance, limited awareness of resources, and physical, cognitive, and behavioral impairments making travel to appointments challenging. Delivering interdisciplinary care remotely using video technology has the potential to improve access to care for patients with LBD.

NCT ID: NCT05012410 Not yet recruiting - Alzheimer Disease Clinical Trials

WeCareAdvisor Study for Caregivers of People Living With Dementia

Start date: September 2021
Phase: N/A
Study type: Interventional

The WeCareAdvisor is an online tool to help caregivers manage behavioral and psychological symptoms of people living with dementia. The trial will evaluate its efficacy to reduce caregiver distress, improve confidence managing behaviors, as well as reduce occurrences and severity of behavioral and psychological symptoms.

NCT ID: NCT05009524 Not yet recruiting - Alzheimer Disease Clinical Trials

The Interactive Physical and Cognitive Exercise System (v3) for Mild Cognitive Impairment (MCI)

Start date: August 23, 2021
Phase: N/A
Study type: Interventional

The primary purpose of this study is to attempt to replicate and extend promising pilot findings regarding the cognitive benefits of in-home neuro-exergaming with iPACES (interactive Physical and Cognitive Exercise System v3) for persons with mild cognitive impairment (MCI). Participants will include persons with MCI and their co-residing partner who both exercise at home 3-5 times per week for at least 6 months and are followed through one year. All participation is "remote" (completed at home), with all equipment (pedaler, tablet, etc.) supplied directly to the home, and with all study measures completed via videoconference and mail.