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Dementia clinical trials

View clinical trials related to Dementia.

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NCT ID: NCT06331247 Not yet recruiting - Stroke Clinical Trials

MIND Diet to Improve Cognitive Function in Mild Stroke Patients (MINDICOMS) II

Start date: March 18, 2024
Phase: N/A
Study type: Interventional

A 6-month pilot randomized controlled trial designed to test the effect of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet + usual medical care versus usual medical care on cognitive change and several other secondary outcomes through a randomized controlled trial in 60 mild stroke patients aged 35-70 years without dementia.

NCT ID: NCT06330155 Not yet recruiting - Alzheimer Dementia Clinical Trials

A Genetic Study for Alzheimer Dementia: Case-control Study

Start date: March 26, 2024
Phase:
Study type: Observational

The purpose of this study is to find out the difference in genetic test results between Alzheimer's dementia patients and healthy subjects. We want to identify genes that are importantly related to Alzheimer's dementia.

NCT ID: NCT06327022 Completed - Quality of Life Clinical Trials

Social Media-based Electronic Bibliotherapy for Dementia Caregivers

Start date: July 1, 2022
Phase: N/A
Study type: Interventional

This study aims to assess the efficacy of social media-based electronic bibliotherapy in improving the well-being of informal caregivers of people with dementia compared to a control group.

NCT ID: NCT06326424 Not yet recruiting - Dementia Clinical Trials

Delirium Identification in Older Patients With Alzheimer's and Other Related Dementias In the Emergency Department

DELIRIUM
Start date: April 10, 2024
Phase:
Study type: Observational

Delirium is highly prevalent and very bad for patients with dementia. Delirium is a dangerous medical condition that occurs in 6-38% of older Emergency Department patients and 70% of ICU patients. A person who develops delirium in the ED or hospital has a 12 times higher odds of being newly diagnosed with dementia in the next year compared to a similar patient who does not become delirious. Delirium is especially dangerous for persons living with Alzheimer Disease and Related Dementias (AD/ADRD). Persons living with ADRD have an almost 50% chance of developing delirium in the hospital. Clinicians are bad at recognizing delirium. A recent systematic review led by the Geriatric Emergency Care Applied Research network (NIH funded) found that current delirium screening tools are at most 64% sensitive, meaning that physicians can identify some phenotypes of delirium well, but cannot easily rule out delirium in acutely ill older patients. The investigators propose integrating wrist biosensors into the emergency management of older adults with dementia. The investigators will monitor heart rate variability, movement, and electrodermal activity (electrical activity of at the level of the skin) to determine if an array of biosensors more sensitive to delirium than current verbal screening tools.

NCT ID: NCT06322121 Recruiting - Dementia Clinical Trials

Vascular Aspects in Dementia: Part 2

Start date: September 4, 2023
Phase:
Study type: Observational

Cerebral amyloid angiopathy (CAA), a common cerebrovascular small vessel disease (SVD), is a frequently (98%) found co-morbidity at autopsy in patients with Alzheimer's disease (AD). Current in vivo hallmarks of CAA represent changes relatively late in the disease process and leaves CAA in AD often undetected. Recently, it was shown that decreased vascular reactivity (VR) measured with blood oxygen level dependent (BOLD) MRI, after visual stimulus, is an early CAA marker. With BOLD-MRI to detect decreased VR in different stages of AD, it was shown that increasing stages of AD associate with decreasing VR independent of age, classic SVD markers and atrophy. Moreover, VR is associated with cognitive deficits. Therefore, cross-sectional data indicate that decreased VR is an important co-morbidity already in early stages of AD with an independent effect on disease severity. In this respect, the study aim is to determine the natural course of the decrease of VR in both controls and (early stage) AD patients to monitor AD disease progression. This is an essential step to aid in the development and application of effective treatment as it is expected that CAA can cause/worsen AD pathology.

NCT ID: NCT06321588 Recruiting - Dementia Clinical Trials

Autoimmune Dementia: Predictors of Neuronal Synaptic Antibodies in Patients With New-ONset Cognitive Impairment

ADONIS
Start date: May 10, 2023
Phase:
Study type: Observational

The goal of this observational study is to investigate the frequency and the possible pathogenic role of neuronal synaptic antibodies (NSAb) in patients with cognitive impairment (CI). The main questions it aims to answer are: 1. the frequency and associated features of NSAb in patients with CI and the usefulness of a clinical score in improving autoimmune dementia (AID) diagnosis; 2. the clinical significance of NSAb in patients with CI not fulfilling the autoimmune encephalitis (AE) criteria and serum NSAb (NSAb-pos-CI); 3. the impact of blood-brain-barrier (BBB) dysfunction on their pathogenicity.

NCT ID: NCT06321380 Not yet recruiting - Alzheimer Disease Clinical Trials

Working Memory Functioning in Alzheimer's Disease and Vascular Dementia

MEMTRAV-COG
Start date: April 2024
Phase:
Study type: Observational [Patient Registry]

The aim of the present study is to investigate potential cognitive mechanisms contributing to working memory impairment in Alzheimer's disease and vascular dementia. The investigators consider a new hypothesis suggesting that difficulties in mobilizing maintenance strategies of information could explain this working memory deficit. More specifically, the investigators assume that patient groups will have difficulties in employing both refreshing and elaborative strategies during a working memory task (i.e., complex span task), as compared to a control group.

NCT ID: NCT06320093 Completed - Dementia Clinical Trials

Training Social and Health Care prOfessionals in mUsic-based Therapeutic iNterventions to Support Older People With Dementia

SOUND
Start date: October 3, 2023
Phase: N/A
Study type: Interventional

The study will investigate the effects of an inovative intervention based on the use of music on 45 professionals in the field of dementia, 45 elderly people with dementia.

NCT ID: NCT06313853 Not yet recruiting - Cancer Clinical Trials

Enhancing Triadic Communication About Cognition for Older Adults With Alzheimer's Disease or Related Dementias Facing a Cancer Management Decision

COACH-Cog
Start date: March 15, 2024
Phase: N/A
Study type: Interventional

Building upon prior work, the investigator team developed a communication intervention for older adults with ADRD who are considering a decision about cancer management (adapted intervention: COACH-Cog). The investigators hypothesize that for patients with dual diagnoses of ADRD and cancer, COACH-Cog will increase autonomy support of care partners and patients in the decision-making process, leading to greater acknowledgement and support of cognitive concerns and cognitive-related goals, thereby improving goal concordant care. The investigators are conducting a pilot randomized controlled trial (RCT; cluster randomized by physician) including approximately 45 oncology clinicians and 130 patient/care partner dyads evaluating the effect of COACH-Cog on care partner and patient autonomy support, care partner well-being, goal-concordance, and communication.

NCT ID: NCT06307197 Recruiting - Dementia Clinical Trials

HAAL: HeAlthy Ageing Eco-system for peopLe With Dementia

HAAL
Start date: October 2, 2023
Phase: N/A
Study type: Interventional

HAAL project aims to test several technological devices in order to improve the quality of life of older people with dementia and their informal and formal caregiver.