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COVID-19 clinical trials

View clinical trials related to COVID-19.

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NCT ID: NCT04632537 Withdrawn - COVID-19 Clinical Trials

BCG Vaccination to Prevent COVID-19

Start date: December 7, 2020
Phase: Phase 3
Study type: Interventional

The current COVID-19 epidemic threatens to overwhelm the capacity of many countries to meet their populations' health care needs. Although several vaccines specific for SARS-CoV-2 have been or are being developed, these require testing in animal and human safety studies and they are unlikely to be available during the expected peak periods of the growing epidemic. Two groups at especially high risk of infection and disease are front line health care workers working directly with COVID-19 patients and elderly residents of group homes or facilities that provide skilled nursing care to this frail population. Interim measures to protect these groups while we await a high efficacy vaccine are desperately needed. Based on the capacity of BCG to (1) reduce the incidence of respiratory tract infections in children and adults; (2) exert antiviral effects in experimental models; and (3) reduce viremia in an experimental human model of viral infection, we hypothesize that BCG vaccination may induce (partial) protection against susceptibility to and/or severity of SARS-CoV-2 infection. This study will evaluate the efficacy of BCG to reduce risk of infection by SARS-CoV-2 and mitigate COVID-19 disease severity in at risk health care providers. A phase III randomized controlled trial provides the highest validity to answer this research question. Given the immediate threat of the SARS-CoV-2 epidemic the trial has been designed as a pragmatic study with a highly feasible primary endpoint, which can be continuously measured. This allows for the most rapid identification of a beneficial outcome that would allow other at-risk individuals, including the control population, to also benefit from the intervention if and as soon as it has demonstrated efficacy and safety.

NCT ID: NCT04603690 Withdrawn - Covid-19 Clinical Trials

Study to Investigate the Benefits of Colchicine in Patients With COVID-19

Start date: December 15, 2020
Phase: Phase 3
Study type: Interventional

COVID-19 is associated with a cytokine storm that leads to respiratory distress, multiorgan failure and elevated mortality. Oral Colchicine exhibits high anti-inflammatory capacity attributed to the inhibition of microtubules polymerization, inflammasome and production of IL-1β and IL-6, which could prevent the inflammatory storm in COVID-19 patients at risk. The investigators present a randomized, controlled, open-labeled, and pragmatic clinical trial to study the treatment effect of Colchicine in COVID-19 patients requiring hospitalization, but no intensive care yet. Colchicine will be started within the first 48 hours and continue for 14 days using a descending dose. The benefits will be studied in terms of clinical evolution (WHO 7-point scale) and IL-6 levels, as well as other clinical and biochemical secondary end-points. In the case of positive results, the clinical impact would be relevant given that this oral medication is affordable and widely accessible which would help to prevent the inflammatory complications associated with COVID-19.

NCT ID: NCT04537975 Withdrawn - COVID-19 Clinical Trials

C2Rx Hemofiltration Treatment in Severe or Critically Ill Adults With COVID-19

Start date: September 15, 2020
Phase: N/A
Study type: Interventional

The clinical trial will evaluate the short term and extended impact on on respiration, pulmonary function and cardiovascular function in C2Rx treatment verse Standard of Care (SOC) in critically ill adults with COVID-19 infections .

NCT ID: NCT04528927 Withdrawn - COVID 19 Clinical Trials

Evaluation of the Efficacy and Safety of Treatments for Patients Hospitalized for COVID-19 Infection Without Signs of Acute Respiratory Failure, in Tunisia

Start date: May 15, 2020
Phase: Phase 3
Study type: Interventional

Evaluation of the efficacy and safety of Treatments for Patients Hospitalized for COVID-19 Infection without signs of acute respiratory failure, in Tunisia Multicentric Randomized Comparative Study

NCT ID: NCT04522817 Withdrawn - Covid-19 Clinical Trials

CLBS119 for Repair of COVID-19 Induced Pulmonary Damage

Start date: October 5, 2020
Phase: Phase 1
Study type: Interventional

This clinical trial will explore the safety and potential efficacy of CLBS119 for the repair of COVID-19 induced pulmonary damage in adults.

NCT ID: NCT04502069 Withdrawn - COVID-19 Clinical Trials

Treatment of COVID-19 With Opaganib in Patients With Pneumonia Requiring Oxygen

Start date: August 2020
Phase: Phase 1/Phase 2
Study type: Interventional

Patients diagnosed with COVID-19 infection will be offered treatment with Opaganib, 500 mg Q12 hours. Opaganib will be continuously administered for up to 2 weeks, until discharged on room air (if earlier than 2 weeks).

NCT ID: NCT04477642 Withdrawn - COVID-19 Clinical Trials

Abatacept for Patients With COVID-19 and Respiratory Distress

Start date: August 2020
Phase: Phase 1/Phase 2
Study type: Interventional

This is a single-arm open label trial for hospitalized patients with COVID-19 (Coronavirus). The primary endpoint of the study is to assess the requirement for mechanical ventilation in patients who are admitted to the hospital with COVID-19 infection and a Pulse Oxygen Level </= 93% on room air. The primary endpoint analysis will be performed using all enrolled patients.

NCT ID: NCT04467151 Withdrawn - COVID-19 Clinical Trials

Administration of Anti-SARS-CoV-2 Convalescent Plasma in Hospitalized, Non-ICU Patients With COVID-19

Start date: October 2020
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the efficacy and safety of the administration of anti-SARS-CoV-2 convalescent plasma in COVID-19 patients who are sick enough to warrant hospitalization, but not yet admitted to the ICU (prior to the onset of overwhelming disease including a systemic inflammatory response, sepsis, and/or ARDS).

NCT ID: NCT04459702 Withdrawn - COVID-19 Clinical Trials

A Study of Combination Therapies to Treat COVID-19 Infection

Start date: July 2020
Phase: Phase 2
Study type: Interventional

This study seeks to determine whether dual or quadruple therapy is more effective in treating COVID-19.

NCT ID: NCT04456088 Withdrawn - COVID-19 Clinical Trials

Inhaled NO for the Treatment of COVID-19 Caused by SARS-CoV-2 (CANADA Trial)

Start date: July 15, 2020
Phase: Phase 2
Study type: Interventional

The purpose of this open label, 2-phase, study is to obtain information on the safety of 80 ppm and the safety and efficacy of 150 ppm Nitric Oxide given in addition to the standard of care of patients with COVID-19 caused by SARS-CoV-2.