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Covid19 clinical trials

View clinical trials related to Covid19.

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NCT ID: NCT05087524 Terminated - COVID-19 Clinical Trials

BinaxNOW for Evaluating Children for Infection With SARS-CoV-2

Start date: January 9, 2021
Phase: N/A
Study type: Interventional

This is a study of the BinaxNOW Covid-19 Ag Card as a method to rapidly identify SARS-CoV-2 infection in asymptomatic children, teachers, and other school staff for exclusion. 240 students and 80 teachers in the Madison Metropolitan School District (MMSD) will be enrolled and can expect to be on study for up to 8 weeks.

NCT ID: NCT04810949 Terminated - Covid19 Clinical Trials

Vitamine D3 Supplementation in Patients With Serum Values +/- 20ng/ml

Start date: August 5, 2020
Phase: N/A
Study type: Interventional

A comparative randomized study that will evaluate the effect of a monthly supplementation with 52000 units of Vitamine D3 vs hygienic-dietary measures in the development of respiratory infections such as COVID-19, H1N1, A, B Influenza during 6 months of follow-up in patients with serum vitamin D values +/- 20ng/ml.

NCT ID: NCT04748783 Terminated - COVID19 Clinical Trials

Antiviral Efficacy and Acceptability of Mouth Rinses for Inactivation of COVID-19

COL
Start date: March 26, 2021
Phase: Phase 2
Study type: Interventional

Subjects (125) will be randomized to one of five mouthrinses and will be asked to give a saliva sample immediately before and after a 30-60 second mouthwash. Saliva samples will be collected from subjects at 15-minute intervals thereafter up to one hour (15, 30, 45 and 60 min). The saliva will be used for RT-PCR detection of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) and viral infectivity assays, along with quantitative cytokine and chemokine concentration (pg/mL, Luminex). Subjects will complete a short survey on the taste and experience of using the mouthwash. Peripheral blood will be collected at the end of salivary collection. Subjects, except controls, will be provided materials and oral hygiene instruction related to daily use of oral hygiene products. In the seven-day period between study visit one and study visit two, subjects will be directed to brush with Colgate toothpaste (at least twice per day) and rinse with the Colgate mouthrinse (according to on-label procedures). Controls are asked to carry out their typical oral hygiene regimen with the products they typically use. All subjects keep a daily diary of oral hygiene performance, product usage, COVID-19 symptoms and exposures. Subjects complete study visit two one week after the baseline visit during which additional salivary (1 time point, 2 mL of saliva over 5 min, no rinse) will occur and blood samples collected. each subject will undergo a periodontal exam.

NCT ID: NCT04748120 Terminated - Covid19 Clinical Trials

Operative vs Non-Operative Management of Acute Appendicitis and Acute Cholecystitis in COVID-19 Positive Patients

Start date: December 28, 2020
Phase: N/A
Study type: Interventional

This study evaluates operative and non-operative management of acute appendicitis (infection or inflammation of the appendix) and acute cholecystitis (inflammation/infection of the gallbladder) in patients with active mild to moderate COVID-19 infection. The hypothesis is that COVID+ patients with uncomplicated acute appendicitis or acute cholecystitis amendable to a laparoscopic procedure can have safe operative outcomes compared to those managed non-operatively.

NCT ID: NCT04746430 Terminated - Covid19 Clinical Trials

COVID-19 Primary Care Platform for Early Treatment and Recovery (COPPER) Study

COPPER
Start date: February 16, 2021
Phase: Phase 4
Study type: Interventional

The COVID-19 coronavirus has led to a global pandemic of respiratory diseases with an increase in hospitalization and death risk. To keep COVID-19 manageable for healthcare, early treatment is urgently needed to avoid hospitalization. Dexamethasone can dampen the exaggerated cytokine response to COVID-19 and is a promising agent for preventing disease aggravation, hospitalization and death. However, the evidence on the effectiveness, safety and cost-effectiveness of dexamethasone treatment in primary care is inconclusive.

NCT ID: NCT04734873 Terminated - Covid-19 Clinical Trials

CPI-006 Plus Standard of Care Versus Placebo Plus Standard of Care in Mild to Moderately Symptomatic Hospitalized Covid-19 Patients

Start date: February 25, 2021
Phase: Phase 3
Study type: Interventional

This is a phase 3, randomized, placebo controlled, double-blind, multicenter, stratified study of CPI-006 plus standard of care (SOC) versus placebo plus SOC in mild to moderately symptomatic hospitalized Covid-19 patients with the primary objective to compare the proportion of participants alive and respiratory failure free between CPI-006 plus SOC versus placebo plus SOC.

NCT ID: NCT04725097 Terminated - Covid19 Clinical Trials

A Study to Evaluate Rapid Throughput Screening for Human COVID-19 Infection

Start date: December 10, 2020
Phase:
Study type: Observational

The purpose of this study is to assess the ability of an artificial intelligence smartphone-enabled point of care ECG to detect COVID-19.

NCT ID: NCT04709068 Terminated - Covid19 Clinical Trials

Risk Stratification and Early Alerting Regarding COVID-19 Hospitalization

RiskSEARCH
Start date: February 8, 2021
Phase:
Study type: Observational

The purpose of this research is to remotely monitor individuals who have tested positive for COVID-19 to learn more about progression and recovery from the disease. Individuals who test positive for COVID-19 will wear the Current Health wearable device continuously and answer a brief series of questions on Current Health tablet daily for up to 30 days. The health data will be used to develop predictive models of hospitalization risk.

NCT ID: NCT04698993 Terminated - Covid19 Clinical Trials

Dräger COVID-19 Antigen Test Clinical Performance Study

Start date: February 12, 2021
Phase: N/A
Study type: Interventional

The study is designed to demonstrate suitability of the Dräger Antigen Test for SARS-CoV-2 detection in clinical nasal specimens. Real-time polymerase chain reaction (RT-PCR) on specimens collected by pharyngeal swabs serves as a reference method.

NCT ID: NCT04652765 Terminated - Covid19 Clinical Trials

Camostat With Bicalutamide for COVID-19

COMBO
Start date: February 3, 2021
Phase: Phase 1
Study type: Interventional

This will be a randomized, open-label study to determine if camostat+ bicalutamide decreases the proportion of people with COVID-19 who require hospitalization, compared to historical controls. Patients with symptomatic COVID-19, diagnosed as outpatients, will be randomized 1:1, stratified by gender, to treatment with standard of care alone (Arm 1) or with camostat and bicalutamide (Arm 2).