Clinical Trials Logo

Filter by:
NCT ID: NCT06463158 Not yet recruiting - Clinical trials for Well-Being, Psychological

The Impact of the Family Room App on Caregivers

Start date: June 17, 2024
Phase: N/A
Study type: Interventional

BACKGROUND/PURPOSE: Engaging families in patient care during serious illness can enhance care quality, reduce social isolation, boost satisfaction, and lower healthcare costs. Active involvement of family caregivers in patient care remains limited because there are no evidence-based tools to guide clinicians on how to include them effectively. Therefore, the purpose of this study is to conduct a clinical trial that includes information developed while engaged in previous work related to the development and testing of a point-of-care technology that operationalizes caregiver involvement during acute hospitalization The investigators engaged in hypothesis driven customer discovery, then performed an iterative user centered design development and testing process, and now conclude with a clinical trial in the inpatient environment.

NCT ID: NCT06463132 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Phase 1b Clinical Trial to Evaluate PEP and EUFLEXXA for Knee Osteoarthritis (KOA)

Start date: November 1, 2024
Phase: Phase 1
Study type: Interventional

Evaluate the safety and exploratory efficacy of single intra-articular injections of PEP reconstituted with 0.9% Normal Saline at a low dose (one vial PEP) and high dose (two vials PEP), with and without EUFLEXXA, for the treatment of Knee Osteoarthritis

NCT ID: NCT06463054 Recruiting - Emotion Regulation Clinical Trials

Testing an Intergenerational Model of Suicide Risk in Mother-child Dyads

Start date: April 1, 2024
Phase: N/A
Study type: Interventional

The investigators are interested in learning more about how the role of mothers' emotions has on the transmission of suicide risk to children. Eligible participants will be invited to participate in a baseline assessment, and 4 follow-up assessments in the next year. This research study is a randomized control trial. Participants that choose to enroll are randomly assigned, that is by chance (like by flipping a coin) to receive DBT Skills Training or treatment as usual (TAU). Participants may also be selected for DBT skills training, it which would occur once a week for 6 months.

NCT ID: NCT06462911 Not yet recruiting - Epilepsy Clinical Trials

Epilepsy Self-Management for Spanish Speakers: HOBSCOTCH - ESPANOL

Start date: June 2024
Phase: N/A
Study type: Interventional

The goal of this pilot study is to assess the feasibility of translating and delivering the existing home-based epilepsy self-management intervention, HOBSCOTCH, for people with epilepsy whose primary language is Spanish. The main questions it aims to answer are: 1. Can the current HOBSCOTCH program be successfully translated for Spanish speaking people with epilepsy? 2. Will people with epilepsy who speak Spanish experience improved quality of life similar to that found in people with epilepsy who received the HOBSCOTCH program in English? Participants will be asked to: - attend nine, one-hour virtual (online and/or by telephone) HOBSCOTCH-SPANISH sessions with a one-on-one certified bilingual HOBSCOTCH coach - complete a brief clinical questionnaire about their diagnosis of epilepsy - complete two questionnaires before and after the HOBSCOTCH sessions about their quality of life and about memory and thinking processes - keep a short daily diary about their seizures, symptoms and use of the self-management strategies taught in the HOBSCOTCH program - complete a brief Satisfaction Survey and a 3 question survey about shared decision making after the entire HOBSCOTCH program

NCT ID: NCT06462898 Recruiting - Nutrition, Healthy Clinical Trials

The Effect of Omega-3 Fortified Smoothies on Omega-3 Index and Physical Performance Related Outcomes Among Soldiers

H2FO3
Start date: February 1, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to test the effect of omega-3 on physical performance and recovery of Soldiers. Objectives 1: Assess the impact of 8-weeks of daily consumption of 1600mg of omega-3 fortified smoothie on O3I response. Objective 2: Determine the relationship between O3I and measures of performance and recovery. Participants will: - Be randomly assigned to placebo group or to the omega-3 fortified smoothie group. - The intervention group will take omega-3 fortified smoothies and controls will consume a non-fortified smoothie, five days a week for 8 weeks. - Participate in Army Combat Fitness Tests (ACFT) - Complete surveys that assess dietary intake, physical activity (PAQ) and sleep quality (PSQI). - Complete a finger prick to determine omega-3 index. Assessments will be collected pre/post intervention. Researchers will compare intervention and placebo groups to see if omega-3 levels increase, and improve physical performance and recovery.

NCT ID: NCT06462885 Completed - Clinical trials for Perioperative/Postoperative Complications

Living Alone is Predictive of Non-home Discharge Following Elective Total Hip Arthroplasty: a Matched-pairs Cohort Analysis

Start date: January 1, 2021
Phase:
Study type: Observational

The goal of this observational study is to assess the effect of living alone on total hip arthroplasty thirty-day outcomes. The main questions it aims to answer are: Is living alone associated with discharge disposition (home versus non-home)? Is living alone associated with greater incidences of secondary adverse events? Participants will be sampled from the 2021 American College of Surgeons National Surgical Quality Improvement Program

NCT ID: NCT06462820 Not yet recruiting - Clinical trials for Major Depressive Disorder

SAINT for MDD in an Inpatient Setting Follow-on

Start date: June 30, 2024
Phase: Phase 2/Phase 3
Study type: Interventional

Randomized, multi-site, sham-controlled, double-blinded study

NCT ID: NCT06462807 Recruiting - HIV/AIDS Clinical Trials

Improving the Organizational Social Context to Address Structural Racism and Discrimination

Start date: May 31, 2023
Phase: N/A
Study type: Interventional

Despite the widespread use of effective antiretroviral therapy (ART), the HIV epidemic continues to impact racial and ethnic minority populations disproportionately. Although Black/African American persons account for 13% of the U.S. population, they account for 41% of new HIV diagnoses and experience the lowest rates of retention in HIV care and viral suppression (VS) compared to other racial/ethnic groups. Structural racism and discrimination (SRD) likely contribute to racial disparities in HIV outcomes. Although the outpatient setting is a vitally important aspect of care provision for PLWH, there are limited data on the impact of intra-organizational SRD on HIV outcomes. Longitudinal engagement in HIV care is needed for sustained VS, decreased community transmission of HIV. The organizational social context (OSC) includes organizational culture (organizational norms and values that drive quality of care), organizational climate (perception of the culture and how it impacts personal well-being), and workers' attitudes. Using a randomized controlled trial, we will implement ARC (Accessibility, Responsiveness, Continuity) to improve organizational behavior and reduce racial disparities in HIV outcomes for PLWH. ARC is an evidence-based intervention that uses three strategies (ARC principles, ARC component tools, and ARC mental models) to create OSCs that support the implementation of interventions to improve patient outcomes. Clinics will be randomized to ARC (n = 2) or standard of care (SOC; n= 2). Those assigned to ARC will address SRD occurring at the organizational level affecting care, including referral and treatment patterns for PLWH. A pre-implementation period will be followed by ARC and ARC-associated implementation strategies for 36 months and then a 12-month post-implementation period where we will continue to measure HIV outcomes in both arms. We will compare HIV outcomes, namely VS and retention in care, and intermediate outcomes, such as linkage to mental health treatment and staff turn-over in clinics assigned to ARC and SOC. We will also evaluate whether individual (self-efficacy, perceived discrimination) and organizational factors (OSC and cohesion of OSC measures) mediate the relationship between ARC, intermediate, and HIV outcomes. In preparation to the RCT, we will evaluate baseline OSC measures across 12 HIV clinics in Philadelphia and determine aspects of the OSC associated with VS and retention in care in a multi-level model adjusting for neighborhood SRD, patient-level factors, and clustering of patients nested in clinics and neighborhoods. We will then test the effectiveness of ARC in improving a primary outcome of VS and secondary outcome of retention in care at the end of the implementation period. We will examine the acceptability, sustainability, and cost of implementing ARC in outpatient HIV care. This research will advance understanding of the impact of SRD on HIV treatment outcomes and health services research and the implementation of a disseminable evidence-based practice aimed at reducing SRD.

NCT ID: NCT06462794 Not yet recruiting - Solid Tumor, Adult Clinical Trials

First In Human Study of CX-801 in Advanced Solid Tumors

Start date: June 30, 2024
Phase: Phase 1
Study type: Interventional

The purpose of this first-in-human study, CTMX-801-101, is to characterize the safety, tolerability, and antitumor activity of CX-801 as monotherapy and in combination with pembrolizumab in adult participants with advanced solid tumors.

NCT ID: NCT06462781 Not yet recruiting - Refractory Migraine Clinical Trials

Localized Injection of Lidocaine and Glucocorticoid for Headache Treatment

LIGHT
Start date: March 2025
Phase: Phase 2
Study type: Interventional

The goal of this clinical trial is to test whether injecting lidocaine and steroids into two blood vessels of the brain can help treat chronic headaches (migraines). The main questions this study aims to answer are: - Is this treatment safe for chronic migraine patients? - Is this treatment effective for chronic migraine patients? Participants will: - Be treated once with lidocaine and steroid infused into the middle meningeal arteries (two blood vessels in the brain). - Attend appointments scheduled 1 week, 6 weeks, and 12 weeks after the treatment for a checkup. - Keep a log of their symptoms.