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NCT ID: NCT06469398 Active, not recruiting - Acne Vulgaris Clinical Trials

A Post Market Device Study for the Treatment of Acne

Start date: July 21, 2022
Phase: N/A
Study type: Interventional

To evaluate the safety and efficacy of the Cutera laser system for the treatment of acne vulgaris.

NCT ID: NCT06468059 Active, not recruiting - Amputation Clinical Trials

Biomechanical Evaluation of a Novel, Compliant Low Profile Prosthetic Foot

Start date: April 1, 2024
Phase: N/A
Study type: Interventional

The investigators have developed a novel layered low-profile prosthetic foot that is able to provide enhanced compliance without sacrificing strength for individuals with transtibial amputation who have long residual limbs. It is hypothesized that the proposed prosthesis will offer similar benefits to these individuals as comparable higher profile prostheses offer users with shorter residual limbs. The primary goal of this Phase I proposal is to assess the degree to which the proposed prosthesis can provide benefits to prosthesis users in this population, along with characterizing the degree to which the novel prosthesis emulates its taller counterparts.

NCT ID: NCT06466603 Active, not recruiting - Anxiety Clinical Trials

Probiotics for Anxiety Study

Start date: March 4, 2024
Phase:
Study type: Observational

The purpose of this study is to observe the effect of a consumer-grade probiotic capsule called GABA (gamma-aminobutyric acid ) Probiotic ("Study Product"), a probiotic capsule containing Lactiplantibacillus plantarum 815, on anxiety. The purpose of this study is to evaluate the effects of 2 different doses of this probiotic study product on anxiety in comparison to placebo. Additionally, the study aims to observe the effects of the probiotic study product on mood, cognitive function, quality of life and sleep. After the 6-week study product use period, all participants will be given the option to continue using GABA Probiotic for an additional 4 weeks. Participants in this study will complete surveys and questionnaires about their experience before, during and after taking the study product. Additionally, this study will incorporate the use of a wrist-worn electronic device to measure sleep.

NCT ID: NCT06464341 Active, not recruiting - Breast Cancer Clinical Trials

Nodal Burden and Nodal Recurrence in Patients With Isolated Tumor Cells After Neoadjuvant Chemotherapy Treated With Axillary Dissection or Nodal Radiation: the OPBC-05/EUBREAST-14R/ICARO Study

ICARO
Start date: May 4, 2023
Phase:
Study type: Observational

The purposes of this multicenter retrospective cohort study are to determine the residual nodal burden in patients with isolated tumor cells detected in the SLN or the clipped node after NAC and to determine oncologic outcomes in this group of patients after ALND or nodal RT or observation.

NCT ID: NCT06456294 Active, not recruiting - Overdose Clinical Trials

Evaluation of a Medication Health Center to Promote Opioid Safety

Start date: June 15, 2022
Phase: N/A
Study type: Interventional

This study will assess the impact of an opioid safety clinic intervention for patients prescribed chronic opioid therapy. Outcomes are visits to the clinic, naloxone dispensings, Prescription Drug Monitoring reviews, and Urine Drug Screens conducted

NCT ID: NCT06453993 Active, not recruiting - Esophageal Cancer Clinical Trials

Temporal Variation in Exhaled Volatile Organic Compounds in Esophageal Cancer Patients

Start date: December 1, 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate whether exhaled breath can be used to detect and monitor esophageal cancer.

NCT ID: NCT06451263 Active, not recruiting - Ovarian Cancer Clinical Trials

Nudge to Gynecologic Oncology

Start date: January 19, 2024
Phase: N/A
Study type: Interventional

Ovarian cancer lacks an effective screening test, and prompt treatment at diagnosis is the only way to improve outcomes. Referral to gynecologic oncology at diagnosis of adnexal mass is recommend by guidelines from every major medical organization. Yet, 1 in 4 patients with ovarian cancer nationwide and at Penn Medicine never see a gynecologic oncologist. Even when referred to gynecologic oncology, patients from historically-marginalized groups have twice as long duration from diagnosis to seeing gynecologic oncology. In this project, the investigators will pilot a clinician nudge to gynecologic oncology referral and compare the impact to historical controls.

NCT ID: NCT06445465 Active, not recruiting - Parkinson's Disease Clinical Trials

Study to Evaluate a Potential PET Radioligand for Imaging Alpha-synuclein Deposits in the Brain

Start date: December 24, 2020
Phase: Early Phase 1
Study type: Interventional

The overall goal of this protocol is to evaluate [18F]MNI-1216 (also known as [18F]ACI-12589) as an α-synuclein targeted radiopharmaceutical in 3 parts as follows: - Part 1: first in human (FiH) imaging - Optional Part 2: expansion of FiH imaging - Optional Part 3: retest imaging A total of up to 30 participants may be enrolled and participate in the study. Part 1 of the study will include up to 10 participants (target of up to 5 healthy volunteers and up to 5 participants with idiopathic Parkinson's Disease). There will be an ongoing review of study data in Part 1 to evaluate the characteristics of tracer binding and safety. If the study results are deemed adequate in Part 1, Part 2 and/or Part 3 may be initiated. The decision to initiate Part 3 may also include a review of data from Part 2, if Part 2 is performed and the data are available. If performed, Part 2 will include up to 20 participants, including health volunteers and participants with α-synucleinopathies to acquire additional tracer-related data. If performed, Part 3 will include up to 10 participants from in Part 1 and/or Part 2 (including health volunteers and participants with α-synucleinopathies) to evaluate the reliability of [18F]MNI-1216 ([18F]ACI-12589) Positron Emission Tomography (PET) imaging.

NCT ID: NCT06441955 Active, not recruiting - COVID-19, Long Haul Clinical Trials

Covid-19 Long Haul Preventative and Health Promotion Care Clinical Trial Acceleration Program.

Start date: March 1, 2024
Phase: Phase 4
Study type: Interventional

We are conducting a study on alternative treatments for patients who have received an current or previous positive COVID-19 diagnosis with mild-serve symptoms or undiagnosable condition after testing positive for severe acute COVID-19 infection and are experiencing long-haul symptoms. The symptoms of long COVID can include extreme tiredness (fatigue), shortness of breath, memory and concentration issues (brain fog), heart palpitations, dizziness, joint pain, muscle aches, cough, headaches, anxiety, and depression. It's important to note that there are various other symptoms that individuals can experience after a COVID-19 infection, such as loss of smell, chest pain or tightness, difficulty sleeping (insomnia), pins and needles, depression, anxiety, tinnitus, earaches, nausea, diarrhea, stomach aches, loss of appetite, cough, headaches, sore throat, and changes to the sense of smell or taste. To be included in the study, participants must have had symptoms for more than 4 weeks. The goal of the study is to measure biomarkers, identify new ones through clinical trials, and individualize and optimize treatment plans, which may or may not include COVID-19 post-market antivirals, vaccines, and medical care. It's essential to conduct thorough clinical trials to understand the long-term effects of COVID-19 and to develop personalized treatment plans for individuals experiencing long-haul symptoms.

NCT ID: NCT06438003 Active, not recruiting - Obesity Clinical Trials

Improving Healthy Living Opportunities: Laurel HARVEST

Start date: January 27, 2023
Phase: N/A
Study type: Interventional

The goal of this pre-post intervention study is to understand how community-engaged approaches to policy, systems, and environmental approaches can work to improve fruit and vegetable consumption and food security status among an Appalachian Kentucky community. The main approaches taken will be to employ a Community Advisory Board to define our target population of need, and appropriate intervention strategies. The investigators aim to understand if nutrition-based programming and food system approaches for lower-income, single-parent households, and multi-generational households can improve health. Participants will engage in annual data collection to assess dietary quality and food security status.