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NCT ID: NCT06460844 Not yet recruiting - Clinical trials for Retinitis Pigmentosa

Study to Evaluate Safety of RTx-015 Injection in Retinitis Pigmentosa Patients

Start date: August 2024
Phase: Phase 1
Study type: Interventional

A Phase 1, open-label, non-randomized, dose-escalation study, where approximately 9 eligible patients with retinitis pigmentosa will be enrolled sequentially in up to 3 dose cohorts of RTx-015. Enrolled patients will receive a single, unilateral intravitreal injection of RTx-015 in the study eye at Visit 3 (Day 0) and be followed for a total of 12 months.

NCT ID: NCT06460818 Recruiting - Women's Health Clinical Trials

Surgical Sample Collection- Sampling During Uterine Surgery

Start date: February 27, 2024
Phase:
Study type: Observational

The goal of this clinical trial is to evaluate anatomical locations for sample collection for future decisions for diagnostic test development.

NCT ID: NCT06460493 Recruiting - COPD Clinical Trials

Effect of Ensifentrine Treatment on CAT Score

Start date: June 11, 2024
Phase: Phase 3
Study type: Interventional

This is an open-label study at one study center that will assess the effect of twice-daily nebulized ensifentrine on COPD Assessment Test (CAT™) scores over 12 weeks in subjects with moderate to severe COPD. Subjects will continue their long-acting dual or triple COPD maintenance treatments during study participation.

NCT ID: NCT06460350 Not yet recruiting - Clinical trials for Total Knee Arthroplasty

NEUROCUPLE™ in TKA Patients

Start date: June 24, 2024
Phase: N/A
Study type: Interventional

This is a randomized (1:1) placebo-controlled clinical trial to determine the feasibility and effectiveness of 30-day application of NEUROCUPLE™ patch for pain reduction and opioid consumption following TKA. Results will establish NEUROCUPLE™ as an effective non-opioid postoperative pain management device for FDA approval. Importantly, we have a placebo device (device without the captor array layer) that looks exactly like the active device, allowing us to conduct a true placebo randomized study.

NCT ID: NCT06460324 Completed - Multiple Sclerosis Clinical Trials

A Study to Assess COVID-19 Vaccination Immune Response in Multiple Sclerosis Patients Treated With Ofatumumab

Start date: May 20, 2022
Phase:
Study type: Observational

This was a non-interventional, retrospective, observational cohort study involving the abstraction and review of pertinent data from medical records by participating physicians, who completed a customized electronic case report form hosted on the secure electronic data capture system.

NCT ID: NCT06460298 Not yet recruiting - Clinical trials for Triple Negative Breast Cancer

ProAgio in Combination With Gemcitabine in Patients With Metastatic Triple Negative Breast Cancer

Start date: July 1, 2024
Phase: Phase 1/Phase 2
Study type: Interventional

This is a Phase I/II Trial Evaluating the Safety and Efficacy of ProAgio, an anti- αvβ3 Integrin Cytotoxin, in Combination with Gemcitabine in Patients with Metastatic Triple Negative Breast Cancer

NCT ID: NCT06460220 Recruiting - Suicide Clinical Trials

SAFETY-Parent: Online Learning Module to Support Parents of Suicidal Youth

SAFETY-P
Start date: June 10, 2024
Phase: N/A
Study type: Interventional

This project aims to adapt the parent component of Safe Alternatives for Teens and Youth (SAFETY) outpatient intervention to SAFETY-Parent (SAFETY-P), a self-paced interactive learning module for parents, to be implemented as an augmentation for youth being seen for suicidal ideation, suicidal behavior, or recent suicide attempts across multiple settings at Nationwide Children's Hospital (NCH, Columbus, Ohio).

NCT ID: NCT06460181 Recruiting - Mental Fatigue Clinical Trials

Impact of Astaxanthin on Cognition in Recreationally Active Females

Start date: August 1, 2024
Phase: Phase 4
Study type: Interventional

The purpose of this study is to examine the protentional that the antioxidant Astaxanthin has on mitigating cognitive decline following mental fatigue.

NCT ID: NCT06460116 Not yet recruiting - Clinical trials for Educational Problems

Health Equity and Rural Education (HERE!) Clinical Trial

HERE
Start date: July 1, 2024
Phase: N/A
Study type: Interventional

The goal of this community-engaged research is two-fold. The first goal is to gather stakeholder feedback to inform a school-based community health worker intervention with youth with poor school attendance and an enhanced usual care condition. The second goal is to evaluate the feasibility of implementing the school-based community health worker intervention and enhanced usual care approach within rural schools. The main question it aims to answer is whether it is feasibile to recruit children with poor school attendance and their families to the intervention, to complete the trauma-informed intervention, and to complete the associated study measures of meeting social determinants of health/mental health needs, school-based health center utilization, and behavioral helath symptoms. At least 38 rural students in grades 6-12 with poor school attendance and their parents/guardians will meet with the school-based community health worker for support around social determinants of health needs that may be barriers to attendance. Researchers will also assess the feasibility of recruiting at least 10 rural students and their parents/guardians to complete the study measures in an enhanced usual care condition in which the school-based health center without a school-based community health worker is reminded of the availability of an online social services directory.

NCT ID: NCT06459674 Recruiting - Obesity Clinical Trials

Inspiratory Muscle Training in Postmenopausal Women

MRS
Start date: February 7, 2024
Phase: N/A
Study type: Interventional

This study is being conducted by the Department of Kinesiology within the School of Public Health at Indiana University Bloomington. The purpose of this study is to better understand how inspiratory muscle strength training affects cardiovascular health and mood disturbance in postmenopausal women.