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NCT ID: NCT05416112 Recruiting - Chest Pain Clinical Trials

Non-invasive Left Ventricle Contractility dp/dt as Prognostic Marker in Chest Unit Patients

dp/dt
Start date: June 1, 2022
Phase:
Study type: Observational [Patient Registry]

Ischemic heart disease is a major public health problem with high mortality rate despite the progress in management and the resources mobilized. The idea is that myocardial ischemia is generally associated with left ventricular dysfunction and, consequently, a possible alteration of the dp/dt index. As dp/dt could be assessed non-invasively by plethysmographic method, it is interesting to investigate its prognostic performance in patients with indifferentiate chest pain.

NCT ID: NCT05406960 Completed - Hysterectomy Clinical Trials

Therapeutic Effect of Herbal Infusion on Menometrorrhagia

HERBALTREAT
Start date: May 10, 2019
Phase: N/A
Study type: Interventional

This is an interventional, non-randomized, controlled, pilot study that explores a new approach to treat, Abnormal uterine bleeding-menometrorrhagia in women, being candidates for hysterectomy, based on tea infusion consumption of a mixture of two plants.

NCT ID: NCT05380375 Active, not recruiting - COPD Exacerbation Clinical Trials

Short-course Antibiotic Treatment in AECOPD: a Meta-analysis of Double-blind Studies

Start date: February 24, 2022
Phase:
Study type: Observational

Chronic obstructive pulmonary disease (COPD) is a common disease worldwide and a leading cause of death and disability globally. Given that bacteria are implicated in a substantial proportion of acute exacerbation of COPD (AECOPD), antibiotics are frequently used. However, this current practice may lead to antibiotic overuse further increasing drug resistance and side effects. Although the small literature on interventions to prove the effective of short course of antibiotic, a metaanalysis of published randomised double-blind studies comparing the same antibiotics compared to a previous study is performed to determine whether a short course of antibiotic treatment is as effective as a very short course in patients with an exacerbation of COPD (EACOPD). The authors systematically searched electronic databases on the literature of controlled trials on Medline and Embase with no language, location, or time restrictions. The authors retrieved observational and controlled trials comparing different durations of the same oral antibiotic therapy in the treatment of acute exacerbations of COPD. The authors included 30 randomized, placebo-controlled trials for COPD patients. There was no statistically significant difference between shorter and longer antibiotic courses in early clinical success. In conclusion, Short-course antibiotic treatment is as effective as very short-course treatment in patients with mild to moderate exacerbations of chronic bronchitis and COPD.

NCT ID: NCT05369559 Recruiting - Fluid Therapy Clinical Trials

Mini Bolus for Fluid Challenge Responsiveness in the Emergency Department

MIBORED
Start date: March 3, 2022
Phase: Early Phase 1
Study type: Interventional

Intravascular volume expansion is a common intervention in critically ill patients with acute circulatory failure.we test the hypothesis that a mini-bolus fluid challenge, of either 50 ml or 100 ml, can predict fluid responsiveness in spontaneously breathing patients with hemodynamic instability.

NCT ID: NCT05366855 Recruiting - Clinical trials for Generalized Pustular Psoriasis

Long-Term Safety and Efficacy of Imsidolimab (ANB019) in Subjects With Generalized Pustular Psoriasis

GEMINI2
Start date: April 21, 2022
Phase: Phase 3
Study type: Interventional

This is a Phase 3, long term extension study to evaluate the safety and efficacy of imsidolimab compared with placebo in adult subjects with generalized pustular psoriasis (GPP).

NCT ID: NCT05361759 Recruiting - Clinical trials for Cardiac Implantable Electronic Devices

National Tunisian Registry of Cardiac Implantable Electronic Devices

NATURE-CIED
Start date: January 18, 2021
Phase:
Study type: Observational [Patient Registry]

The National Tunisian Registry of Cardiac Implantable Electronic Devices is an observational, prospective and multicenter study aiming to assess the epidemiological, clinical and therapeutic profile of cardiac implantable electronic Devices in Tunisia. Cardiologists from both sectors (public and private) are participating in the study, with 26 investigational centers. Data is captured electronically by DACIMA Clinical Suite, according to FDA 21 CFR part 11 (Food and Drug Administration 21 Code of Federal Regulations part 11), HIPAA (Health Insurance Portability and Accountability Act) & ICH (International Conference on Harmonisation) requirements.

NCT ID: NCT05359302 Recruiting - Quality of Life Clinical Trials

Effects of Ramadan Fasting on Sleeping and Quality of Life

Start date: March 15, 2022
Phase:
Study type: Observational [Patient Registry]

Include participants who intend to practice Ramadan fasting and accept to complete the three part of the study .

NCT ID: NCT05352893 Recruiting - Clinical trials for Generalized Pustular Psoriasis

Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Subjects With GPP

GEMINI1
Start date: April 14, 2022
Phase: Phase 3
Study type: Interventional

This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of imsidolimab compared with placebo in adult subjects with generalized pustular psoriasis (GPP).

NCT ID: NCT05352490 Completed - Dyspnea Clinical Trials

Diagnosis of Heart Failure in Chronic Obstructive Pulmonary Disease Using the Lung Ultrasound

Start date: March 9, 2022
Phase:
Study type: Observational

Acute Heart failure (AHF) is a common cause of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This association is frequently underestimated with regard to the difficulty of clinical diagnosis. The investigators expect that the application of the lung ultrasound could be useful in this issue.

NCT ID: NCT05340972 Recruiting - Heart Diseases Clinical Trials

Evaluate the Predictive Impact of the MEESSI Score

MEESSI
Start date: January 15, 2009
Phase:
Study type: Observational

Our primary purpose is to assess MEESSI score in predicting mortality and readmission of patients managed for acute heart failure (AHF) in Emergency Department. European Society of Cardiology recommend risk stratification for patients with AHF.