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NCT ID: NCT03528967 Recruiting - Clinical trials for Placental Insufficiency

ENOXAPARINE in the Prevention of Placental Insufficiency in Pregnant Women

PRESANCE
Start date: October 23, 2013
Phase: Phase 4
Study type: Interventional

Assessment of the effectiveness of Enoxaparin, at a preventive dose, combined with Aspirin treatment versus Aspirin only treatment in reducing placental insufficiency in pregnant women.

NCT ID: NCT03505814 Recruiting - Weaning Failure Clinical Trials

Interest of High Flow Nasal Cannula Oxygen Therapy in Pediatric Intensive Care Unit

Start date: March 1, 2017
Phase: N/A
Study type: Interventional

monocentric randomized controlled trial starting from Mars 2017, recruitment is still ongoing. Patients aged between 0-45 days needing mechanical ventilation (MV) with tracheal intubation were included random assignation in two groups for post-extubation management: Group Optiflow (GO) for patients receiving High Flow Nasal Cannula Oxygen Therapy HNFC and Control Group (CG) for conventional treatment. Patients were evaluated during the first 72h following extubation. Primary endpoint was the incidence of reintubation. Secondary endpoints were incidence of post-extubation respiratory failure, time to reintubate and weaning time from oxygen. Respiratory and hemodynamic parameters were assessed and compared between the two groups upon extubation, after 2 hours (H2), at H6, H12, H24, H36, H48 and H72. Length of stay (LOS) and mortality were also estimated.

NCT ID: NCT03488277 Recruiting - Clinical trials for Effects of; Anesthesia, Spinal and Epidural, in Pregnancy

Leg Elevation for Prevention of Post Spinal Hypotension in Cesarean Section

Start date: January 10, 2018
Phase: N/A
Study type: Interventional

Prospective trial including full term parturients scheduled for a cesarean section under spinal anesthesia. patients are being randomly assigned into 2 groups: LE group: will be positioned in 15° left tilt with leg elevation with a 30cm height pillow under the heels, this position will be hold after spinal anesthesia until fetal extraction. Control group: will be positioned in supine with 15° left tilt. the 2 groups will receive a 10ml/kg of crystalloid co-load intravenously, and the spinal anesthesia will be performed in sitting position with the same dose of Bupivacain, morphine and sufentanil.

NCT ID: NCT03484065 Recruiting - Clinical trials for Afibrinogenemia, Congenital

Quality of Life in Patients With Congenital Afibrinogenemia

QualyAFIB
Start date: June 2016
Phase:
Study type: Observational

The aim of this observational study is to evaluate the quality of life in patients with congenital afibrinogenemia using the Haemo-QoL SF for kids and the Haem-A-QoL for adult patients.

NCT ID: NCT03480828 Completed - Clinical trials for Accuracy of DE and DTF in Prediction of Extubation Success

Diaphragm Ultrasound to Predict Weaning Outcomes in Mechanically Ventilated Patients

Start date: April 1, 2017
Phase:
Study type: Observational

This trial enrolled all the adult patients who were mechanically ventilated for more than 48 hours and met all creteria for extubation. Patients who needed reintubation for upper aiway obstruction, neurological or hemodynamic alteration were excluded. The diaphragm ultrasound was performed during spontaneous breathing test or pressure support ventilation trial measuring the dipahragmatic excursion (DE) and the diaphragm thickening fraction (DTF) whithin 24 hours before extubation.

NCT ID: NCT03466411 Not yet recruiting - Crohn's Disease Clinical Trials

A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease

GALAXI
Start date: April 13, 2018
Phase: Phase 3
Study type: Interventional

The purpose of this program is to evaluate the efficacy and safety of guselkumab in participants with Crohn's disease.

NCT ID: NCT03458078 Completed - Pain, Postoperative Clinical Trials

Analgesic Efficacy of Two Adjuvants During Spinal Anaesthesia.

Start date: February 1, 2017
Phase: Phase 2/Phase 3
Study type: Interventional

: Pain modulation is very important after operation, particularly for women who undergo caesarean section. A pain-free postoperative period is essential following a caesarean section so new mothers may care for and bond with their neonates. The consequences of the improper pain management which raise the healthcare costs and prolong the recovery process. Intrathecal adjuvants are often administered during this procedure to provide significant analgesia, but they may also have bothersome side effects. Intrathecal midazolam and magnesium sulfate produces effective postoperative analgesia with no significant side effects. Objectives: This prospective, randomized, double-blind study was designed to compare the analgesic efficacy and safety of intrathecal midazolam vs. Magnesium sulfate vs plain bupivacaine as an adjunct to bupivacaine in pregnancy patients scheduled for elective caesarean section.

NCT ID: NCT03440060 Recruiting - Clinical trials for Acute Exacerbation Copd

Procalcitonin-guided Antibiotic Therapy During Severe Acute Exacerbation of COPD

Start date: October 5, 2017
Phase: N/A
Study type: Interventional

This study assess whether a procalcitonin guided antibiotic therapy can reduce significantly unnecessary antibiotic prescription during severe exacerbation of COPD requiring mechanical ventilation without compromising patients' outcome. The first group of patients will receive systematically empiric antibiotic therapy and the second group will receive antibiotics only if procalcitonin value is at or greater than 0.25 ng/ml.

NCT ID: NCT03434691 Recruiting - Septic Shock Clinical Trials

Effects of Dexmedetomidine vs Midazolam on Microcirculation in Septic Shock Patients

Start date: February 8, 2018
Phase: N/A
Study type: Interventional

To investigate changes in the concentration of glucose, lactate, pyruvate and glycerol in the extracellular fluid of the skeletal muscle following Dexmedetomidine administration in patients with septic shock.

NCT ID: NCT03428880 Completed - Block Clinical Trials

Ultrasound Guided QLB III Versus Intrathecal Morphine for Analgesia After Cesarean Section

QLB
Start date: February 15, 2017
Phase: Phase 4
Study type: Interventional

Subarachnoid morphine (SAM) is the gold standard for treating postoperative pain after cesarean delivery (CD) but it has undesirable side effects, that's why the aim of our study is to identify whether ultrasound-guided Quadratus lumborum block type 3, a new regional anesthetic technique that blocks the abdominal wall neural afferents, can provide at the same time better postoperative analgesia after CD with less side effects