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NCT ID: NCT03631875 Recruiting - Clinical trials for Anesthesia Intubation Complication

Co-induction Ketamine-propofol: Effects on Laryngeal Mask Airway Insertion Conditions in Children

Start date: June 1, 2018
Phase: Phase 4
Study type: Interventional

Background: Large doses of propofol needed for induction and laryngeal mask (LM) insertion in children may be associated with hemodynamic sides effects. Co-induction with low doses of ketamine 0.5 mg/ kg has the advantage of reducing dose and therefore maintaining hemodynamic stability. Aim: To examine the effect of co-induction on LM insertion, hemodynamics and recovery in children

NCT ID: NCT03629522 Completed - Cesarean Section Clinical Trials

Effects of Ondansetron on Hemodynamics in Cesarean Section Under Spinal Anesthesia

Start date: August 1, 2017
Phase: Phase 4
Study type: Interventional

BACKGROUND: Spinal anesthesia (SA) induced maternal hypotension is the most frequent and troublesome complication in cesarean section (CS), compromising both maternal and neonatal well-being. Many strategies have been used to prevent its occurrence but no single technique has been confirmed to be completely effective. the investigators hypothesized that ondansetron, a serotonin-receptor-antagonist, could have beneficial effects on maternal hemodynamics during CS under SA. METHODS: In this prospective double-blind placebo-controlled study, one hundred healthy parturients were randomized to receive either 8 mg of intravenous ondansetron (group O) or the same volume of saline (group S), 5 minutes prior to the induction of SA. All women received a coloading volume of 500 ml of saline. Maternal hemodynamics: blood pressure, heart rate and cardiac output (CO) were measured with a non-invasive device based on pulse wave transit time: the esCCO device Nihon Kohden hemodynamic monitor. Ephedrine was administered to treat hypotension (systolic blood pressure less than 80% of baseline).

NCT ID: NCT03627598 Recruiting - Clinical trials for Hypercapnic Respiratory Failure

High Flow Oxygen and Non Invasive Ventilation for Hypercapnic Respiratory Failure

Start date: July 1, 2018
Phase: N/A
Study type: Interventional

this study evaluates high flow oxygen therapy in addition to non invasive ventilation (NIV) to treat hypercapnic respiratory failure. Between sessions of NIV, half of participants will have high flow nasal cannula while the others will have standard low flow oxygen therapy.

NCT ID: NCT03626753 Completed - Postoperative Pain Clinical Trials

Comparison of Two Routes of Administration of a Multimodal Analgesic Protocol in Postoperative Cesarean Section

Start date: January 1, 2015
Phase: Phase 2/Phase 3
Study type: Interventional

Many drugs with various mechanisms of action are used for postcaesarean pain relief. Although the response to pain relief is sometimes believed to be individual, it is very important to establish the most effective with the least adverse effects type of oral analgesia for women after caesarean section. Optimal pain control post-caesarean section will benefit not only the mother and her baby, but also a healthcare system. Optimal pain control may shorten the time spent in hospital after caesarean section and, therefore, reduce healthcare costs.

NCT ID: NCT03625388 Not yet recruiting - Clinical trials for Chronic Myelogenous Leukemia

Low Dose Dasatinib (50 mg Daily) as First-line Treatment for Newly Diagnosed Chronic‐Phase Chronic Myeloid Leukemia

Start date: October 2018
Phase: Phase 2
Study type: Interventional

The purpose of this multicenter randomized study is to compare efficacy and safety of dasatinib 50 mg once daily and dasatinib 100 mg once daily in patients with early chronic phase (CP) chronic myeloid leukemia (CML)

NCT ID: NCT03604952 Completed - COPD Clinical Trials

Effects of Ramadan Observance in Male Patients With Chronic Obstructive Pulmonary Disease

Start date: June 18, 2015
Study type: Observational [Patient Registry]

Purpose: To analyze the effects of Ramadan observance (RO) on pulmonary variables, exercise performance and postural balance in patients with chronic obstructive pulmonary disease (COPD). Methods: Twenty COPD patients (age=72.7 ± 4.1 yr, non-smokers, without cardiac or neuromuscular complications) were evaluated. Tests performed one week before Ramadan (C), and during the second (R-2) and the fourth weeks of Ramadan (R-4) included standard spirometry, a quality of life questionnaire (VQ11), a 6-min walking test (6MWT), measurement of maximal voluntary contraction force of the quadriceps (MVC), Timed Get Up and Go (TUG), Berg Balance Scale (BBS) and Unipedal Stance (UST).

NCT ID: NCT03585829 Enrolling by invitation - Fasting Clinical Trials

Ramadan Fasting in Patients With Corticotrope Deficiency Treated Either by Hydrocortisone or by Prednisolone

Start date: May 17, 2018
Phase: Phase 4
Study type: Interventional

Selected patients will be randomised to either hydrocortisone or prednisolone. Each treatment period is of 14 days. Abnormal clinical symptoms, blood glucose and quality of life will be monitored.

NCT ID: NCT03580187 Recruiting - Clinical trials for Blunt Injury of Thorax

Nebulized Morphine in Chest Trauma Patients: A Prospective Study

Start date: January 10, 2014
Phase: Phase 3
Study type: Interventional

This is a prospective study carried out from 2014 to 2016 including patients aged ≥ 18 years, admitted for isolated chest trauma. Each patient received a nebulization of 10 mg morphine. If Visual Analog Score (VAS) assessed after 10 minutes still> 4, nebulization was repeated every 10 minutes until pain relief. At 30 minutes, VAS> 4 means failure.

NCT ID: NCT03577080 Completed - COPD Clinical Trials

Chronic Obstructive Pulmonary Disease

Start date: October 28, 2016
Phase: N/A
Study type: Interventional

Chronic Obstructive Pulmonary Disease (COPD) is a preventable respiratory characterized by airflow obstruction that is not fully reversible. This disease a major cause of mortality worldwide. It is projected to rank the third-leading cause of death in 2020. The objective of this study is to examine the effects of a physical therapy intervention in stable patients with COPD.

NCT ID: NCT03528967 Completed - Clinical trials for Placental Insufficiency

Enoxaparin in the Prevention of Placental Insufficiency in Pregnant Women

Start date: October 23, 2013
Phase: Phase 4
Study type: Interventional

Assessment of the effectiveness of Enoxaparin, at a preventive dose, combined with Aspirin treatment versus Aspirin only treatment in reducing placental insufficiency in pregnant women.