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NCT ID: NCT03752931 Not yet recruiting - Clinical trials for Postoperative Cardiac Complication

Celiprolol Versus Ditiazem for the Prevention of Postoperative Cardiac Arrythmias in Thoracic Surgery

Start date: December 2018
Phase: Phase 2
Study type: Interventional

Cardiac arrythmias are the most common cardiac complications after thoracic surgery. They are made primarily of postoperative atrial fibrillation (POAF). They are associated with an increased risk of stroke, increased length of hospital stay and cost of care, and increased long-term mortality. Randomized , single-blind prospective study in the anesthesia and intensive care department of Abderrahmen Mami hospital Ariana Tunisia comparing the efficacy of Diltiazem versus Celiprolol in the prevention of postoperative cardiac arrythmias in patients proposed for pneumonectomy and bilobectomy.

NCT ID: NCT03741907 Recruiting - Cesarean Section Clinical Trials

Comparing French Ambulatory and MISGAV-LADACH C-Section Techniques

Start date: August 27, 2018
Phase: N/A
Study type: Interventional

In the last decades cesarean section rates are getting higher in many countries. The rise in those rates encourages obstetricians to improve operative techniques for a better maternal and fetal outcome. Despite its worldwide spread, a general consensus on the most appropriate technique to use has not yet been reached. The most known surgical technique is the MLC . A modified extraperitoneal method of caesarean section :" French Ambulatory Cesarean Section ( FAUCS) was described in the middle of the 90's by "Denis Fauck" and "Jacques Henri Ravina " However, no study comparing these two cesarean techniques was conducted. From where the investigators initiate this study .

NCT ID: NCT03724448 Recruiting - Clinical trials for Diagnosis, Psychiatric

The Efficacy of a Herbal Supplement in the Prevention of PTSD

Start date: May 1, 2018
Phase: Phase 1
Study type: Interventional

Psycho-traumatic disorders are a disabling condition whose epidemiological data vary according to the country but also the populations studied and the measuring instruments used. The estimated prevalence of posttraumatic stress disorder (PTSD) appeared to be increasing in recent years, and this appears to be due, among other things, to the improvement of the standardized evaluation procedure. The survey "Mental Health in General Population", conducted in metropolitan France between 1999 and 2003 on more than 36,000 people estimated its instantaneous prevalence (last month) of a full PTSD was 0.7% in the SMPG overall sample, with almost equal frequency between men (45%) and women (55%). This figure is close to that reported in a European population for the ESEMeD study. A very significant psychiatric comorbidity was found in subjects with PTSD, particularly with mood disorders, other anxiety disorders and addictive behaviors. The link with the suicidal risk was clearly established, which is the gravity of this pathology. The most important publications are made by American teams who have identified and evaluated the treatment of this pathology among veterans of the various wars led by the country.

NCT ID: NCT03717779 Not yet recruiting - Dyspnea; Cardiac Clinical Trials

Contribution LUS in the Diagnosis of Acute Heart Failure (AHF) in Patients Admitted to the ED

Start date: November 20, 2018
Study type: Observational

This study assesses the potential of lung ultrasonography to diagnose heart failure.

NCT ID: NCT03715790 Not yet recruiting - Clinical trials for Acute Myocardial Infarction

Improve SCA Bridge Study

Start date: November 2018
Study type: Observational

The purpose of the Improve SCA Bridge study is to characterize the care pathway flow of post‐acute myocardial infarction (MI) patients as a result of standard assessments of left ventricular ejection fraction (LVEF) in the acute phase (≤14 days post‐ acute MI) and chronic phase (≥40‐90 days post‐acute MI).

NCT ID: NCT03706755 Completed - Anesthesia Clinical Trials

Comparison of Two Doses of Norepinephrine in Preventing Hypotension After Spinal Anesthesia

Start date: May 3, 2018
Phase: Phase 4
Study type: Interventional

The purpose of the study is to determine the more effective intravenous bolus of norepinephrine for maintaining blood pressure during a spinal anesthesia for a cesarean delivery with the fewer side effects. Low blood pressure has been shown to decrease uterine perfusion and foetal outcomes during cesarean delivery under spinal anesthesia. For elective or semi-urgent cesarean delivery, all participants will receive spinal anesthesia with a local anesthetic and either sufentanil or fentanyl. This study plans to enroll 124 pregnant women. Patients will be randomly assigned according to a computer generated system to be in one of two groups.

NCT ID: NCT03704909 Recruiting - Clinical trials for Maternal Hypotension

Epinephrine vs Ephedrine to Prevent Maternal Hypotension During Cesarean Section

Start date: September 1, 2018
Phase: Phase 4
Study type: Interventional

Spinal anesthesia is the preferred method for elective cesarean sections due to considerable risks regarding airway management associated with physiological changes of pregnancy. Cesarean sections normally require an anesthetic block at T4 level, so maternal hypotension is reported to occur in up to 80% of spinal anesthesia cases. This can result in significant morbidity for both the mother and fetus.The purpose of this study is to determine if an intravenous bolus of epinephrine is as effective and safe compared to an intravenous bolus of ephedrine associated with crystalloid coloading for maintaining arterial blood pressure during cesarean deliveries under spinal anesthesia. All participants will receive spinal anesthesia with a local anesthetic and sufentanil. This study plans to enroll 120 pregnant women. Patients will be randomly assigned according to a computer generated system to be in one of two groups.

NCT ID: NCT03701256 Completed - Clinical trials for Neuromuscular Blockade

Bilateral Transversus Abdominis Plane Block Versus Atracurium During Laparoscopic Gynecology Procedures.

Start date: February 1, 2015
Phase: Phase 4
Study type: Interventional

A monocentric, prospective, randomized controlled trial, including patients proposed for a laparoscopic gynecologic surgery comparing the muscular relaxing effect of a bilateral ultrasound-guided Transversus Abdominis Plane block to usual neuromuscular blockade agent (Atracurium)

NCT ID: NCT03700346 Recruiting - Septic Shock Clinical Trials

Muscle Lactate and Lactate to Pyruvate Ratio Clearance in Septic Shock Patients

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

We conducted this study aiming to assess the performance of muscle Lactate and lactate to pyruvate (L/P) ratio clearance in predicting mortality in septic shock patients by using microdialysis.

NCT ID: NCT03698682 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Short Compared With Standard Duration of Antibiotic Treatment for AECOPD

Start date: September 2013
Phase: Phase 2
Study type: Interventional

Chronic obstructive pulmonary disease (COPD) is one of the most common diseases in the world. Acute exacerbation of COPD (AECOPD) refers to an exaggeration of the symptoms of the disease. Currently, the 3 Anthonisen criteria appear to be most satisfactory in defining the AECOPD: The increase in the volume of sputum, the alteration of its appearance which becomes purulent and The increase in dyspnea. Our recent study, showed that administration of levofloxacin is superior to placebo in the treatment of AECOPD; it is accompanied by a substantial reduction in mortality and a significant reduction in the residence time in hospital.The choice of antibiotic to be used in this situation is challenging to the clinician who must choose between traditional antibiotics (cyclins, aminopenicillins, cotrimoxazole...) and new antimicrobial agents. Antibiotic treatment duration was not based on a strong scientific rationale. Yet at the time of the dramatic emergence of bacterial resistance, reducing the selection pressure by reducing the exposure to antibiotic should be a major issue. In addition, the decrease in costs and associated side effects reinforces the interest of short treatments. Unfortunately, few studies with a satisfactory methodology are available in the literature. In fact, we present the rational and the interest in shortening the durations of antibiotic treatment of AECOPD by levofloxacin in patients admitted to the emergency for exacerbation of COPD and to study the epidemiology of viral and bacterial AECOPD.