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NCT ID: NCT03701256 Completed - Clinical trials for Neuromuscular Blockade

Bilateral Transversus Abdominis Plane Block Versus Atracurium During Laparoscopic Gynecology Procedures.

Start date: February 1, 2015
Phase: Phase 4
Study type: Interventional

A monocentric, prospective, randomized controlled trial, including patients proposed for a laparoscopic gynecologic surgery comparing the muscular relaxing effect of a bilateral ultrasound-guided Transversus Abdominis Plane block to usual neuromuscular blockade agent (Atracurium)

NCT ID: NCT03700346 Recruiting - Septic Shock Clinical Trials

Muscle Lactate and Lactate to Pyruvate Ratio Clearance in Septic Shock Patients

ClMLsepsis
Start date: January 1, 2018
Phase: N/A
Study type: Interventional

We conducted this study aiming to assess the performance of muscle Lactate and lactate to pyruvate (L/P) ratio clearance in predicting mortality in septic shock patients by using microdialysis.

NCT ID: NCT03698682 Recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

Short Compared With Standard Duration of Antibiotic Treatment for AECOPD

AECOPD
Start date: September 2013
Phase: Phase 2
Study type: Interventional

Chronic obstructive pulmonary disease (COPD) is one of the most common diseases in the world. Acute exacerbation of COPD (AECOPD) refers to an exaggeration of the symptoms of the disease. Currently, the 3 Anthonisen criteria appear to be most satisfactory in defining the AECOPD: The increase in the volume of sputum, the alteration of its appearance which becomes purulent and The increase in dyspnea. Our recent study, showed that administration of levofloxacin is superior to placebo in the treatment of AECOPD; it is accompanied by a substantial reduction in mortality and a significant reduction in the residence time in hospital.The choice of antibiotic to be used in this situation is challenging to the clinician who must choose between traditional antibiotics (cyclins, aminopenicillins, cotrimoxazole...) and new antimicrobial agents. Antibiotic treatment duration was not based on a strong scientific rationale. Yet at the time of the dramatic emergence of bacterial resistance, reducing the selection pressure by reducing the exposure to antibiotic should be a major issue. In addition, the decrease in costs and associated side effects reinforces the interest of short treatments. Unfortunately, few studies with a satisfactory methodology are available in the literature. In fact, we present the rational and the interest in shortening the durations of antibiotic treatment of AECOPD by levofloxacin in patients admitted to the emergency for exacerbation of COPD and to study the epidemiology of viral and bacterial AECOPD.

NCT ID: NCT03631875 Recruiting - Clinical trials for Anesthesia Intubation Complication

Co-induction Ketamine-propofol: Effects on Laryngeal Mask Airway Insertion Conditions in Children

Start date: June 1, 2018
Phase: Phase 4
Study type: Interventional

Background: Large doses of propofol needed for induction and laryngeal mask (LM) insertion in children may be associated with hemodynamic sides effects. Co-induction with low doses of ketamine 0.5 mg/ kg has the advantage of reducing dose and therefore maintaining hemodynamic stability. Aim: To examine the effect of co-induction on LM insertion, hemodynamics and recovery in children

NCT ID: NCT03629522 Completed - Cesarean Section Clinical Trials

Effects of Ondansetron on Hemodynamics in Cesarean Section Under Spinal Anesthesia

EffOnd
Start date: August 1, 2017
Phase: Phase 4
Study type: Interventional

BACKGROUND: Spinal anesthesia (SA) induced maternal hypotension is the most frequent and troublesome complication in cesarean section (CS), compromising both maternal and neonatal well-being. Many strategies have been used to prevent its occurrence but no single technique has been confirmed to be completely effective. the investigators hypothesized that ondansetron, a serotonin-receptor-antagonist, could have beneficial effects on maternal hemodynamics during CS under SA. METHODS: In this prospective double-blind placebo-controlled study, one hundred healthy parturients were randomized to receive either 8 mg of intravenous ondansetron (group O) or the same volume of saline (group S), 5 minutes prior to the induction of SA. All women received a coloading volume of 500 ml of saline. Maternal hemodynamics: blood pressure, heart rate and cardiac output (CO) were measured with a non-invasive device based on pulse wave transit time: the esCCO device Nihon Kohden hemodynamic monitor. Ephedrine was administered to treat hypotension (systolic blood pressure less than 80% of baseline).

NCT ID: NCT03627598 Recruiting - Clinical trials for Hypercapnic Respiratory Failure

High Flow Oxygen and Non Invasive Ventilation for Hypercapnic Respiratory Failure

Start date: July 1, 2018
Phase: N/A
Study type: Interventional

this study evaluates high flow oxygen therapy in addition to non invasive ventilation (NIV) to treat hypercapnic respiratory failure. Between sessions of NIV, half of participants will have high flow nasal cannula while the others will have standard low flow oxygen therapy.

NCT ID: NCT03626753 Completed - Postoperative Pain Clinical Trials

Comparison of Two Routes of Administration of a Multimodal Analgesic Protocol in Postoperative Cesarean Section

Start date: January 1, 2015
Phase: Phase 2/Phase 3
Study type: Interventional

Many drugs with various mechanisms of action are used for postcaesarean pain relief. Although the response to pain relief is sometimes believed to be individual, it is very important to establish the most effective with the least adverse effects type of oral analgesia for women after caesarean section. Optimal pain control post-caesarean section will benefit not only the mother and her baby, but also a healthcare system. Optimal pain control may shorten the time spent in hospital after caesarean section and, therefore, reduce healthcare costs.

NCT ID: NCT03625388 Not yet recruiting - Clinical trials for Chronic Myelogenous Leukemia

Low Dose Dasatinib (50 mg Daily) as First-line Treatment for Newly Diagnosed Chronic‐Phase Chronic Myeloid Leukemia

Start date: October 2018
Phase: Phase 2
Study type: Interventional

The purpose of this multicenter randomized study is to compare efficacy and safety of dasatinib 50 mg once daily and dasatinib 100 mg once daily in patients with early chronic phase (CP) chronic myeloid leukemia (CML)

NCT ID: NCT03604952 Completed - COPD Clinical Trials

Effects of Ramadan Observance in Male Patients With Chronic Obstructive Pulmonary Disease

Start date: June 18, 2015
Phase:
Study type: Observational [Patient Registry]

Purpose: To analyze the effects of Ramadan observance (RO) on pulmonary variables, exercise performance and postural balance in patients with chronic obstructive pulmonary disease (COPD). Methods: Twenty COPD patients (age=72.7 ± 4.1 yr, non-smokers, without cardiac or neuromuscular complications) were evaluated. Tests performed one week before Ramadan (C), and during the second (R-2) and the fourth weeks of Ramadan (R-4) included standard spirometry, a quality of life questionnaire (VQ11), a 6-min walking test (6MWT), measurement of maximal voluntary contraction force of the quadriceps (MVC), Timed Get Up and Go (TUG), Berg Balance Scale (BBS) and Unipedal Stance (UST).

NCT ID: NCT03585829 Enrolling by invitation - Fasting Clinical Trials

Ramadan Fasting in Patients With Corticotrope Deficiency Treated Either by Hydrocortisone or by Prednisolone

Start date: May 17, 2018
Phase: Phase 4
Study type: Interventional

Selected patients will be randomised to either hydrocortisone or prednisolone. Each treatment period is of 14 days. Abnormal clinical symptoms, blood glucose and quality of life will be monitored.