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NCT ID: NCT05205135 Active, not recruiting - Dementia Clinical Trials

Feasibility Study of Project Carer Matters for Family Caregivers of Persons With Dementia

Start date: March 1, 2021
Phase:
Study type: Observational

The study uses the Reach, Effectiveness, Adoption, Implementation and Maintenance (RE-AIM) framework to assess the Carer Matters programme for dementia caregivers in Singapore. A parallel mixed-methods study design is applied to assess the programme's feasibility and effectiveness.

NCT ID: NCT05204901 Not yet recruiting - Clinical trials for Gastrointestinal Diseases

Using Magnetic Field Tracking to Confirm Nasogastric Tube Placement at Point of Care

Start date: January 17, 2022
Phase: N/A
Study type: Interventional

This is a trial on the feasibility of magnetic tracking for the confirmation of nasogastric tube location in human patients.

NCT ID: NCT05203848 Active, not recruiting - Healthy Aging Clinical Trials

Community Dance Program (CDP) for Older Adults

Start date: September 9, 2021
Phase: Phase 1
Study type: Interventional

Objectives: The primary objective of the proposed project is to develop and evaluate a Community Dance Program (CDP) for community-dwelling older adults, which is aimed at promoting physical strength, balance, cognition, mental and psycho-social well-being of the older adults. A distinctive feature of our project is that a team of researchers across disciplines and community partners will collaborate to develop the program and bring benefits to the older adults living in the community.

NCT ID: NCT05203406 Recruiting - Physical Activity Clinical Trials

The Cardio-Sarcopenia Study

Start date: February 1, 2022
Phase:
Study type: Observational

The use of surrogate markers such as body mass index (BMI) as a target outcome of physical activity may not be appropriate in older adults who are at risk of muscle sarcopenia. In the presence of sarcopenia, reductions in body weight may lead to lower BMI values. We have previously found deleterious changes in cardiac structure and function among sarcopenic older adults, raising a possible biological syndrome of 'cardio-sarcopenia'. In this study, we will investigate the impact of physical activity on temporal changes in cardiac and skeletal muscle , and BMI, over six- to twelve month period, on older adults with this syndrome. By targeting the cardio-sarcopenic phenotype as a modifiable risk factor that may be altered by physical activity, the results will provide new knowledge into retarding deleterious consequences of cardiovascular ageing. This new target challenges the paradigm of using BMI as an anthropometric marker in health prevention. If proven, this will dramatically change primary prevention targets among older adults, justifying the use of cardio-sarcopenia as a rational anthropometric target.

NCT ID: NCT05201950 Not yet recruiting - Education, Medical Clinical Trials

Study of Virtual Simulated Resuscitation in Junior Clinicians

Start date: January 2022
Phase: N/A
Study type: Interventional

The investigators seek to examine the impact of virtual patient simulation on junior clinicians' resuscitation skills in an academic emergency department. Exposure to real life resuscitation cases is opportunistic, with variation in case mix across different junior clinicians. Junior clinicians are closely supervised during resuscitations, with limited independence to make decisions, for patient safety. High fidelity simulation, such as in-situ mock codes with a high fidelity manikin, is resource intensive. Constraints in facilitator and learner time and manpower reduce the feasibility of holding large numbers of simulations for large numbers of learners, leading to limited breadth of case mix exposure in simulation cases. Virtual patient simulation may allow greater and more uniform breadth of exposure and allow automated feedback and rapid cycle deliberate practiceacross a wide range of cases, with reduced resource intensiveness, and prepare them to better utilise limited opportunities for resuscitation during real life or high fidelity simulation. Virtual simulators have been found to be useful for improving skills rather than knowledge or attitudes in health professions education. Such skills include communication, radiograph interpretation, dermatological diagnosis, and cardiac arrest procedures. What is not known is: 1. Whether going directly to in-situ simulation with a high fidelity manikin is the best learning approach for resuscitation, given its potentially detrimental high cognitive load, compared to going first to virtual patient simulation. 2. Whether the benefits of virtual simulation extend beyond cardiac arrest and to other resuscitation scenarios, such as trauma, sepsis, and others. The investigators' hypothesis is that in junior clinicians in the emergency department who have received didactic materials in trauma and sepsis resuscitation, proceeding next to learning by virtual patient resuscitation simulation is associated with improved scores in resuscitation performance for trauma and sepsis, as measured by checklists of required actions during observed in-situ simulation with a high-fidelity manikin, compared to proceeding next to learning by team-based in-situ simulation with a high fidelity manikin. This pilot study aims to determine the feasibility of a randomised controlled trial to test the above hypothesis.

NCT ID: NCT05198479 Not yet recruiting - Clinical trials for Metastatic Nasopharyngeal Cancer

Phase II 177Lu-DOTATATE Study in Metastatic NPC With a Safety run-in

SG-AAA-II-01
Start date: March 2022
Phase: Phase 2
Study type: Interventional

This study is the first phase II study of 177Lu-DOTA0-Tyr3-Octreotate in metastatic NPC. Patients whom have failed 2 or more lines of therapy or exhausted standard therapy and are avid on 68Ga-DOTATATE imaging will be eligible to receive up to 4 cycles of 177Lu-DOTA0-Tyr3-Octreotate. The primary outcome will be progression free survival at 6 months.

NCT ID: NCT05198193 Recruiting - Falls Prevention Clinical Trials

Evaluation and Development of Falls Prevention and Management in the Community for Older Adults

Start date: February 1, 2022
Phase: N/A
Study type: Interventional

This study investigates how differently-framed messages can affect people's attitude towards falls risk and prevention in older adults. This study considers the potentiality of adult children acting as change agents in influencing parents in falls prevention.

NCT ID: NCT05196750 Active, not recruiting - Behavior Clinical Trials

Effect of Obstetric Anesthesia and Delivery Mode On Neurodevelopmental And Behavioural Outcomes In A Population-Based Birth Cohort

Start date: August 1, 2021
Phase:
Study type: Observational

The study aims to determine: 1. The association between Obstetric anesthesia events at delivery (such as mode of anesthesia, drugs given, desaturation and hypotension) on pediatric neurodevelopmental and behavioural outcomes. 2. Mode of delivery on pediatric neurodevelopmental and behavioural outcomes. 3. Effect of labour epidural analgesia on neurodevelopmental and behavioural outcomes. 4. To determine if these would differ between very preterm, moderate preterm, late preterm and term infants. The study team hypothesise that: 1. Adverse maternal events during anesthesia and labor analgesia may be associated with poorer neurodevelopmental outcomes in infants. 2. Delivery via a lower segment caesarean section (LSCS) combined with a general anesthetic during delivery may be associated with adverse pediatric neurodevelopmental and behavioural outcomes. 3. The use of labour epidural analgesia is associated with poorer neurodevelopmental and behavioural outcomes. 4. These differences may be more pronounced in preterm infants as compared to term infants.

NCT ID: NCT05194436 Recruiting - Asthma Clinical Trials

Wheeze Detection Using Aevice Medical Device

Start date: April 23, 2021
Phase:
Study type: Observational

The primary objective of this study is to determine if Aevice Medical Device can detect wheeze as accurately as a physician through auscultation. The secondary objective is to investigate if Aevice Medical Device can be used for remote auscultation of the lung.

NCT ID: NCT05188625 Completed - Clinical trials for Gestational Diabetes

Online Self-learning for Women With Gestational Diabetes Mellitus

iSelf-Learn
Start date: January 13, 2021
Phase: N/A
Study type: Interventional

This study aims to determine the feasibility and acceptability of using telehealth in the care of women with Gestational Diabetes Mellitus (GDM) by providing a self-learning alternative via an online portal compared to a one-to-one dietary education, conducted face-to-face in a dietitian clinic. The investigators hypothesize that the use of technology would enable a higher percentage of women to receive the necessary dietary education, thereby empowering behaviour change and resulting in positive maternal blood glucose control and pregnancy outcomes. The primary hypothesis is that the new care model will reach out to a higher proportion compared to the conventional model (Service utilization), as determined by the completion of the online self-learning, comparing it to attendance rates with the conventional model. The secondary hypothesis is that the new care model will be able to provide care that would be comparable to those in the traditional outpatient clinic setting, as measured by the blood glucose and pregnancy outcomes, as well as patient satisfaction and patient experience.