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Obstructive Sleep Apnea clinical trials

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NCT ID: NCT05077748 Not yet recruiting - Clinical trials for Obstructive Sleep Apnea

An 18-year Follow-up Study on OSA in a Population-based Cohort

Start date: October 20, 2021
Phase:
Study type: Observational

Our research team has established a polysomnography (PSG) quantified population-based paediatric sleep cohort in 2003 for a childhood OSA prevalence study. Subjects were recruited from 13 randomly selected primary schools. All subjects from this original cohort will be invited to join this 18-year follow-up study to repeat the following data collection: questionnaires, anthropometric measurement, sleep study, 24-hour ambulatory blood pressure (ABP) measurement, echocardiography and neurocognitive assessment.

NCT ID: NCT05074056 Not yet recruiting - Clinical trials for Obstructive Sleep Apnea

Ketorolac on Postoperative Pain Reduction in Pediatric Patients With Adenotonsillectomy

Start date: October 1, 2021
Phase: N/A
Study type: Interventional

Postoperative pain management in pediatric patient with tonsillectomy is challenging. Despite being used in many procedures for postoperative pain management, perioperative ketorolac usage in pediatric tonsillectomy surgery is very limited. A recent survey shows that only 8.2% of anesthesiologists use NSAIDS for perioperative management of children with OSA undergoing adenotonsillectomy. We propose to conduct a perspective, randomized study to investigate the opioid-sparing effect of perioperative ketorolac in pediatric patients who have tonsillectomy.

NCT ID: NCT05067088 Recruiting - Clinical trials for Obstructive Sleep Apnea

Novel physIologiC prEdictors of Positive Airway Pressure Effectiveness

NICEPAP
Start date: January 1, 2022
Phase:
Study type: Observational

Millions of Americans suffer from high blood pressure, diabetes, strokes and motor vehicle accidents due to ineffective treatment of obstructive sleep apnea (OSA). Our preliminary data suggest that physiological causes of OSA such as easy arousability (low arousal threshold) or unstable breathing control (high loop gain) may influence effectiveness of OSA's most common treatment, continuous positive airway pressure (CPAP). The NICE-PAP study will examine how the physiologic traits that cause OSA in each individual impact CPAP effectiveness and can lead to personalized OSA treatments that improve patient lives.

NCT ID: NCT05057975 Not yet recruiting - Clinical trials for Obstructive Sleep Apnea

Validation of an Integrated Digital Solution (SUNrise®) Versus Polysomnography for Obstructive Sleep Apnea Diagnosis

SUNSAS
Start date: October 2021
Phase: N/A
Study type: Interventional

Validation of an integrated digital solution (SUNrise®) of mandibular movement automatic analysis by artificial intelligence versus polysomnography for obstructive sleep apnea diagnosis: a prospective, randomized, parallel-arm, open-label, multicenter, national, controlled study.

NCT ID: NCT05055271 Active, not recruiting - Clinical trials for Obstructive Sleep Apnea

Delphi Consensus Excessive Daytime Sleepiness in OSA

Start date: April 1, 2021
Phase:
Study type: Observational

The objective of this study is to generate expert consensus statements on the differential diagnosis, definition, and management of EDS in patients with OSA who are adequately treated with primary therapy.

NCT ID: NCT05053685 Recruiting - Clinical trials for Obstructive Sleep Apnea

Metanephrines in Obstructive Sleep Apnoea

Start date: July 29, 2020
Phase:
Study type: Observational

Although most patients have essential (unexplained) hypertension, some patients have a treatable underlying condition. One such condition is phaeochromocytoma, a tumour that produces excessive stress hormones. Left undiagnosed, patients may develop a hypertensive crisis that can be fatal. Measurements of stress hormones (both 24-hour urine collection and morning blood tests) are highly sensitive for detecting these tumours. However, these stress hormones may also be elevated in obstructive sleep apnoea (OSA) which affects 1 in 5 adults. The investigators hypothesize that in patients with OSA, blood tests will be better than 24-hr urine tests at ruling out a tumour. If this is confirmed, then OSA patients with suspected phaeochromocytoma could be investigated with a morning blood test instead of a traditional urine test, reducing unnecessary additional tests and patient anxiety. In this single site study, the investigators plan to recruit 70 patients undergoing polysomnography. 24hr urine and bloods will be measured. Patients with elevated hormone levels will undergo imaging to rule out a tumour. The primary outcome will be the accuracy of each test in ruling out a tumour. The secondary outcomes will be the relationship between stress hormone level and severity of OSA, which may help to explain the increased cardiovascular risk in patients with OSA, and the change in stress hormone level with treatment for OSA

NCT ID: NCT05050383 Not yet recruiting - Clinical trials for Obstructive Sleep Apnea

DISE: Phenotyping Obstruction Patterns

DISE-PhOP
Start date: September 2021
Phase: N/A
Study type: Interventional

Drug-induced sleep endoscopy (DISE) represents an opportunity to evaluate the upper airway in sleep-like conditions. In its current clinical form, however, DISE does not routinely determine the functional impact of anatomic and neuromuscular factors on airflow obstruction. We will apply nasal pressure (CPAP) during DISE to generate pressure-flow and pressure-area relationships, deriving functional determinants of upper airway obstruction during sleep. In addition, we will use objective anatomic measurements from computerized tomography (CT) and submental ultrasound. Our findings will allow us to streamline the upper airway exam during DISE, and will further the goal of developing personalized solutions that address specific pathogenic mechanisms of pharyngeal collapse and airflow obstruction during sleep. We will use the physiologic and anatomic features derived from DISE and imaging to determine which are predictive of success to standard-of-care surgical interventions (e.g. skeletal, soft tissue, neurostimulation) .

NCT ID: NCT05049369 Not yet recruiting - Clinical trials for Obstructive Sleep Apnea

Long-term Results of Tonsillectomy in the Treatment of Obstructive Sleep Apnea in Adults

Start date: November 1, 2021
Phase: N/A
Study type: Interventional

Long-term results of tonsillectomy in the treatment of obstructive sleep apnea in adults

NCT ID: NCT05049135 Not yet recruiting - Clinical trials for Obstructive Sleep Apnea

Feasibility of a Sensor-less Sleep Monitor (Somnofy®) in Diagnosis and Follow-up in Obstructive Sleep Apnea.

Start date: September 2021
Phase:
Study type: Observational

To evaluate the feasibility of a sensor-less sleep monitor (Somnofy®) in diagnosis and follow-up in obstructive sleep apnea. The study will explore the monitor's usefulness in detection of apnea during sleep, and compare the data to standard diagnostic registrations.

NCT ID: NCT05043389 Recruiting - Clinical trials for Obstructive Sleep Apnea

Impact of Myofuntional Therapy Program on Increasing Tongue Strength and Improving Sleep Apnea

Start date: January 1, 2021
Phase: N/A
Study type: Interventional

This Research studies for compare muscle strength among OSA patients who treat with myofunctional therapy program in Rajavithi hospital