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NCT ID: NCT03841630 Not yet recruiting - Healthy Clinical Trials

A Safety Study of LY3437943 Given as a Single Injection in Healthy Participants

Start date: March 13, 2019
Phase: Phase 1
Study type: Interventional

This study is being conducted to determine the side effects related to LY3437943 given as a single injection under the skin to healthy participants. Blood tests will be performed to check how much LY3437943 gets into the bloodstream and how long the body takes to get rid of it. Each enrolled participant will receive a single dose of LY3437943 or placebo. The study will last up to approximately 71 days for each participant, including screening.

NCT ID: NCT03840668 Not yet recruiting - Dry Eye Clinical Trials

Acceptability of the Use of USB-Powered Eye Mask

Start date: March 2019
Phase: N/A
Study type: Interventional

Portable USB-powered eyemasks provide convenience to dry eye sufferers to perform eyelid warming at home. Such eyemasks can be plugged into a copyrighted device developed in collaboration with Ngee Ann Polytechnic that tracks patients' usage. This revolutionary device transmits a signal to an online database whenever the device is used. Through our copyrighted Android/ iOS application, you or your physician can monitor the frequency of eyelid warming over a long period.

NCT ID: NCT03839823 Not yet recruiting - Breast Cancer Clinical Trials

Study to Compare the Combination of Ribociclib Plus Goserelin Acetate With Hormonal Therapy Versus Combination Chemotherapy in Premenopausal or Perimenopausal Patients With Advanced or Metastatic Breast Cancer

RIGHT Choice
Start date: February 28, 2019
Phase: Phase 2
Study type: Interventional

To compare the combination of Ribociclib plus goserelin acetate with hormonal therapy versus combination chemotherapy in premenopausal or perimenopausal patients with advanced or metastatic breast cancer

NCT ID: NCT03832101 Recruiting - Multitasking Clinical Trials

Improvement of Facial Recognition Ability and Multitasking

Start date: February 13, 2018
Phase: N/A
Study type: Interventional

This study aims to determine the efficacy of training on facial recognition and multitasking. The researchers hypothesize that participants who have undergone facial recognition and multitasking training will demonstrate an improved facial recognition ability and performance in multi-tasking. The researchers also hypothesize that measures of sustained and selective attention will predict performance on multitasking tasks. This work sets the ground work for future research into if and how facial recognition and multitasking ability can be improved.

NCT ID: NCT03816241 Completed - Organ Donation Clinical Trials

Mechanisms of Nudges on Families' Decision-Making Process

Start date: September 2016
Phase: N/A
Study type: Interventional

As part of a larger study, participants are told to read 1 out of 4 anecdotes depicting an organ donation scenario where they are required to make a decision on behalf of their mother who has just suffered an accident. The participants are then surveyed on their attitudes towards organ donation.

NCT ID: NCT03814161 Not yet recruiting - Clinical trials for Geriatric, Frailty, Emergency Department

FRailty Among Elderly Emergency Department Patients With Outcome Measures

Start date: January 20, 2019
Study type: Observational

Our study aims to compare 4 clinical frailty scores, namely Clinical Frailty Scale (CFS), Edmonton Frail Scale (EFS), FRAIL 5-item scale (FRAIL) and SARC-F Sarcopenia Score (SARC-F), which can potentially be adopted for daily practice in the busy ED. It is timely as we projected that we will be seeing more elderly patients attending the ED for various medical and surgical conditions. Their attendance at the ED would be a good opportunity to screen for frailty among them, and to intervene to prevent adverse outcomes such as ED re-attendance or subsequent hospitalisation that might lead to poor functional outcomes and higher dependence on step-down care facilities.

NCT ID: NCT03813394 Not yet recruiting - Clinical trials for Metastatic Nasopharyngeal Cancer

Bevacizumab and Pembrolizumab Combination in EBER-ISH Positive NPC

Start date: March 1, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

This is a single center, randomized, phase Ib/II open-label study of pembrolizumab (pembro or MK-3475) with or without bevacizumab in patients with recurrent non-curable or metastatic nasopharyngeal carcinoma (NPC).

NCT ID: NCT03813290 Not yet recruiting - Clinical trials for Generalised Anxiety Disorder

A Neuro-Technological Intervention for Adolescents With GAD

Start date: June 2019
Phase: N/A
Study type: Interventional

This study aims to evaluate the safety and acceptability of a basic neuro-technological intervention in the treatment of adolescents with Generalised Anxiety Disorder (GAD). Our technology will deliver a mindfulness-based anxiety regulation intervention through a neuro- / bio-feedback-based virtual reality (VR) game interface that is driven by a novel algorithm.

NCT ID: NCT03811301 Recruiting - Clinical trials for Amyotrophic Lateral Sclerosis

[BrainConnexion] - Neurodevice Phase II Trial

Start date: November 21, 2017
Phase: Phase 2
Study type: Interventional

This study aims to evaluate the safety of a wireless implantable neurodevice microsystem in tetraplegic patients, as well as the efficacy of the electrodes for long-term recording of neural activities and the successful control of an external device.

NCT ID: NCT03809975 Not yet recruiting - Osteoarthritis Clinical Trials

Collaborative Model of Care Between Orthopaedics and Allied Healthcare Professionals Trial (CONnACT)

Start date: January 2019
Phase: N/A
Study type: Interventional

Osteoarthritis knee is the leading cause of chronic disability among older adults. Our current model of care is doctor-centric and inefficient leading to suboptimal use of allied health intervention for effective lifestyle and behaviour changes resulting in potentially, unnecessary surgery. The study is designed using an effectiveness-implementation hybrid study design utilizing a mixed methods approach. The hybrid study has dual aims. The primary aim is to evaluate the clinical effectiveness (pain, function and quality of life) of a 12-week multidisciplinary (Orthopaedics, Physiotherapy, Dietetics, Psychology) personalized, community-based program for patients with knee osteoarthritis through a randomized-controlled trial. The secondary aim is to obtain data that will inform the context for implementation and guide future wider scale application. The investigators hypothesize that this multidisciplinary program is clinically more effective in the treatment of knee osteoarthritis at 12 months compared to standard care.