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NCT ID: NCT00343980 Terminated - Clinical trials for Diabetes Mellitus, Type 2

Safety and Efficacy of Inhaled Pre-prandial Human Insulin in Type 2 Diabetes

Start date: October 10, 2006
Phase: Phase 3
Study type: Interventional

This trial is conducted in Asia, Europe and Oceania. The aim of this research study is to compare the efficacy of adding inhaled preprandial insulin to glimepiride compared to adding rosiglitazone to glimepiride for the treatment of type 2 diabetes and to verify its safety (hypoglycaemia, pulmonary function, body weight, insulin antibodies and side effects)

NCT ID: NCT00332657 Terminated - AMD Clinical Trials

Anecortave Acetate Risk Reduction Trial (AART)

Start date: September 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to demonstrate that Anecortave Acetate for Depot Suspension (15 mg or 30 mg) is safe and effective in arresting the progression of dry age-related macular degeneration (AMD) in patients who are at-risk for progressing to wet AMD.

NCT ID: NCT00310661 Terminated - Clinical trials for Neuroleptic-induced Tardive Dyskinesia

Sarizotan in the Treatment of Neuroleptic-induced Tardive Dyskinesia

Start date: December 2004
Phase: N/A
Study type: Interventional

TD is a troublesome and potentially irreversible side effect associated with the use of neuroleptics. While the newer neuroleptics are improved in this regard, they all still carry the risk of TD. The present study proposes that sarizotan is a potential agent for treating neuroleptic-induced TD based on preliminary data indicating efficacy in the management of dyskinesias associated with Parkinson's disease. Its efficacy is further substantiated by pre-clinical data obtained from the vacuous chewing movement (VCM) model in rats, a model we employ ourselves in investigating the relationship between D2 occupancy and TD. The present study also examines the effects of sarizotan on cognitive function, given the association between TD and cognitive deficits.

NCT ID: NCT00276991 Terminated - HIV Infections Clinical Trials

Traditional CAM Therapy in the Treatment of HIV/AIDS

Start date: November 2007
Phase: Phase 1/Phase 2
Study type: Interventional

This research work is important for the cure/control of HIV infection. The objectives of a treatment case on HIV patient is essentially to bring down the viral load closer to undetectable level. The studies are depend on the potential influence of 'Kallunk Oxide' on the CD4+ T cells and the effectiveness on surface of HIV-1. The basic study is to break surface protein and directly inhibit a protein's increased functions, not only in the CD4+T cell but also CD3 and CD8+ T cells, by appropriate antidote. The 'Yogaprabhava', the drug's effectiveness, and progressive immunity with diet and lifestyle can be more easily studied.

NCT ID: NCT00271167 Terminated - Heart Diseases Clinical Trials

A Trial of INO-1001 in Patients Undergoing Heart Surgery That Involves Heart-lung Bypass

Start date: October 2005
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the safety of INO-1001, an intravenous PARP (poly-[ADP ribose] polymerase) inhibitor, in patients undergoing heart surgery. The study also measures whether INO-1001 reduces the side effects caused by heart-lung bypass machines.

NCT ID: NCT00265382 Terminated - Schizophrenia Clinical Trials

Safety And Tolerability Of Ziprasidone In Adolescents With Schizophrenia

Start date: June 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the safety and tolerability of ziprasidone during long-term open-label administration in adolescents (ages 13-17) with schizophrenia.

NCT ID: NCT00263042 Terminated - Clinical trials for Cardiovascular Disease

Comprehensive Rimonabant Evaluation Study of Cardiovascular ENDpoints and Outcomes

CRESCENDO
Start date: December 2005
Phase: Phase 3
Study type: Interventional

The primary objective is to show whether rimonabant reduces the risk of a heart attack (MI), stroke, or death from an MI or stroke in patients with abdominal obesity with other cardiovascular (CV) risk factors. The secondary objective is to show whether rimonabant reduces the risk of MI, stroke, CV death, or CV hospitalization in these patients.

NCT ID: NCT00261352 Terminated - Type 2 Diabetes Clinical Trials

GALLANT 14 Tesaglitazar vs. Metformin and Fenofibrate

Start date: March 2005
Phase: Phase 3
Study type: Interventional

This is a 24-week study to determine the lipid metabolic effects, safety, and tolerability of tesaglitazar compared with metformin and metformin in combination with fenofibrate in patients with type 2 diabetes and low high-density lipoprotein cholesterol (HDL-C). Improvement in dyslipidemia will be evaluated. The study comprises a 2-week enrollment period, 6-week run-in and a 24-week randomized, double blind, parallel group, multi-center, active controlled (metformin with or without fenofibrate) treatment period and a 3-week follow-up. From visit 2 (run-in), all patients will receive a standardized dose of statin (rosuvastatin)

NCT ID: NCT00257192 Terminated - Schizophrenia Clinical Trials

Safety And Efficacy Of Ziprasidone In Adolescents With Schizophrenia

Start date: April 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine if flexibly-dosed ziprasidone is safe and effective for the treatment of adolescents (ages 13-17) with schizophrenia

NCT ID: NCT00255645 Terminated - Type 2 Diabetes Clinical Trials

G-PLUS (GALLANT, GALLEX and ARMOR - Post Treatment Follow-up Study)

Start date: September 2005
Phase: Phase 3
Study type: Observational

This is a long-term safety follow-up study to assess the post-treatment safety, at 12 and 24 months, in patients with type 2 diabetes after participation in the phaseII/III studies GALLANT, GALLEX and ARMOR. In addition, selected patients, including those with pre-defined laboratory or clinical findings, will have a 12-week post-treatment follow-up visit, including laboratory evaluation and adverse event recording.