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NCT ID: NCT05447091 Completed - Depressive Symptoms Clinical Trials

Examining the Effectiveness of a Tablet Video Game on Mood and Cognition

THRIVE
Start date: June 12, 2022
Phase: N/A
Study type: Interventional

Sustained negative mood and depression are characterized by functional impairment, and significant reduction in quality of life. Cognitive models of depression emphasize the role of impaired cognitive control - the mental abilities determining goal directed behaviors - in contributing to depressive symptoms. Indeed, research findings from subclinical and clinical populations show that depressive symptoms are associated with decreased cognitive control abilities. The THRIVE trial is a double-blind, proof-of-concept randomized controlled trial (RCT). The aims of the study are to investigate the feasibility and efficacy of an innovative, custom-made tablet video game, Legends of Hoa'manu (LOH), which is designed to enhance cognitive control, in alleviating mood and improving cognitive control in adults. Participants with mild to major depressive symptoms will be randomized to receive either LoH or a control intervention. Cognitive control, mood and depressive symptoms will be assessed at baseline, post training, after at a 3-week and a 3-month follow up.

NCT ID: NCT05443659 Completed - Clinical trials for Migraine in Adolescence

Real-world Data Analysis of REN Treatment in Adolescence With Migraine

Start date: July 28, 2022
Phase:
Study type: Observational

This is a Post-marketing study investigating the safety and efficacy of the REN device (Nerivio by Theranica, ISRAEL) in adolescents with migraine. Data analysis concerning the REN treatment efficacy in terms of pain and functional disability as a standalone treatment or in combination with other medications will be performed.

NCT ID: NCT05439551 Completed - Acute Infection Clinical Trials

Evaluating the Analytical Equivalency of Serum and Whole Blood Samples Run on the MeMed Key® Platform (Perseverance Study)

Start date: February 11, 2022
Phase:
Study type: Observational

This is a Prospective, multi-center, sample collection study enrolling pediatric and adult subjects presented to the ED/Urgent care, with symptoms consistent with acute bacterial or viral infection will be recruited according to eligibility criteria. The study is designed to measure the MeMed BV®️ score in whole blood and serum samples and demonstrate the equivalence between the two matrices. Patients will be managed according to the current standard of care per standard institutional procedures.

NCT ID: NCT05439473 Completed - Type2 Diabetes Clinical Trials

Evaluation of the Efficacy and Safety of Curalin as Add-On Therapy in Adults With Type 2 Diabetes Mellitus

Start date: August 3, 2021
Phase: Phase 2
Study type: Interventional

Evaluation of Efficacy and Safety of Curalin As Add-On Therapy in Adults With Type 2 Diabetes Mellitus

NCT ID: NCT05437003 Completed - Clinical trials for Idiopathic Parkinson Disease

A Prospective Study to Evaluate the Correlation Between Oculometric Measurements and Clinical Endpoints in PD Patients

Start date: August 20, 2022
Phase: N/A
Study type: Interventional

This is a prospective study in a cohort of about 500 patients with Idiopathic Parkinson's disease, examined routinely in the neurological outpatient clinic. This study aims to evaluate the correlation between oculometric measures and clinical endpoints. Subjects will be evaluated following a physician examination.The evaluations will include MDS-UPDRS examination, as well as an oculometric evaluation for eye movements. In addition, 500 healthy subjects will be evaluated.

NCT ID: NCT05422989 Completed - COVID-19 Clinical Trials

Public Health Risks and Characteristics of Upper Extremity Trauma During COVID-19

Start date: February 1, 2021
Phase:
Study type: Observational [Patient Registry]

The aim of this study was to evaluate for the first time in the Gaza-strip the characteristics and incidence of Upper Extremity Trauma (UET) during the COVID-19 pandemic. The participants, investigated the characteristics of UET cases, and evaluated the UET primary medical-care. Additionally, also evaluate the obstacles in treating UET in Gaza during the COVID-19 pandemic.

NCT ID: NCT05420961 Completed - Clinical trials for Pneumonia, Pneumococcal

A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V116 in Pneumococcal Vaccine-experienced Adults (V116-006, STRIDE-6)

Start date: July 12, 2022
Phase: Phase 3
Study type: Interventional

This a study of V116 in adults ≥50 years of age who previously received a pneumococcal vaccination ≥1 year before enrollment. The primary objectives of this study are to evaluate the safety, tolerability, and immunogenicity of V116.

NCT ID: NCT05417152 Completed - Clinical trials for Diabetic Retinopathy

Single In-Clinic Encounter With the Notal Vision Home OCT by DME Patients

Start date: June 29, 2022
Phase:
Study type: Observational

In this clinical study the Notal Vision Home OCT (NVHO) Monitoring System will be used to evaluate the ability of patients diagnosed with DME to perform sequential self-images of their eyes with the self-operated NVHO device in a home simulated environment in the doctor's office. The study population will include up to 30 patients, with DR in at least one eye at the time of enrollment. All subjects will be enrolled at one site in Israel.

NCT ID: NCT05415085 Completed - Clinical trials for Coronary Artery Disease

Culprit-first in Primary Percutaneous Coronary Intervention

Start date: May 1, 2021
Phase: N/A
Study type: Interventional

The aim of this study is to assess the impact of culprit-first versus culprit-last percutaneous coronary intervention on the door to balloon time and clinical outcomes in patients with ST-elevation myocardial infarction.

NCT ID: NCT05413031 Completed - Hand Tendon Injury Clinical Trials

Comparing Relative Motion Splint With Static Splint After Hand Extensor Tendon Repair

Start date: January 30, 2018
Phase: N/A
Study type: Interventional

Different splints are used after hand extensor tendon repair (including relative motion splint, static splint, etc.) There is no consensus regarding the benefits of either one. The aim of this study is to compare clinical outcomes after using different orthoses and rehabilitation methods after hand extensor tendon repair. Patients are randomly assigned after signing consent to either immobilization with a static splint or a relative motion splint. Patients are examined after 2 and 5 months postoperatively for finger range of motion, grip strength, and DASH questionnaire.