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NCT ID: NCT03403647 Enrolling by invitation - Clinical trials for Vitamin D Deficiency

Effect of Vitamin D on Everolimus Trough Concentrations Among Heart Transplanted Patients

Start date: January 2018
Phase: N/A
Study type: Interventional

Vitamin D is part of the regular treatment regimen among patients after heart transplantation. Due to potential drug-drug interaction between vitamin D and everolmus, these patients are in increased risk for increased everolimus metabolism, potentially leading to under- immunosupression.

NCT ID: NCT03403205 Not yet recruiting - Wilson Disease Clinical Trials

Efficacy and Safety of WTX101 Administered for 48 Weeks Versus Standard of Care in Wilson Disease Subjects

Start date: January 31, 2018
Phase: Phase 3
Study type: Interventional

Wilson Disease (WD) is an autosomal recessive disorder of impaired copper (CU) transport caused by mutations in the ATP7B gene. WTX101 (bis-choline tetrathiomolybdate) is a first-in-class copper-protein-binding agent with a unique mechanism of action, under investigation as a novel therapy for WD. It is formulated as an enteric coated tablet (15 mg strength) for oral administration. The purpose of this study is to evaluate the efficacy of WTX101 administered for 48 weeks compared to standard of care (SOC) in WD subjects aged 18 and older.

NCT ID: NCT03402841 Not yet recruiting - Clinical trials for Non-Germline BRCA Mutated Ovarian Cancer

Multicentre Study of Olaparib Maintenance Monotherapy in Platinum Sensitive Relapsed Non gBRCAm Ovarian Cancer Patients

OPINION
Start date: January 20, 2018
Phase: Phase 3
Study type: Interventional

The purpose of the study is to assess the efficacy and safety of single-agent olaparib as a maintenance treatment in patients with relapsed High Grade Serous Ovarian Cancer (including patients with primary peritoneal and/or fallopian tube cancer) or high grade endometrioid cancer who do not have known deleterious or suspected deleterious germline BRCA mutations (non-gBRCAm) and who had responded following platinum based chemotherapy.

NCT ID: NCT03402399 Recruiting - Clinical trials for Myelofibrosis, Post PV

Defining the Molecular Risk in Israeli Patients With Secondary Compared to Primary Myelofibrosis

MRMF01
Start date: December 10, 2017
Phase: N/A
Study type: Interventional

The aim of the study is to determine the rate of HMR mutations in PMF and secondary MF (post PV/ET) subjects, and correlate the rate of mutations with clinical features as known prognostic scores.

NCT ID: NCT03400943 Not yet recruiting - Leiomyoma Clinical Trials

Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids (ASTEROID 3)

Start date: February 20, 2018
Phase: Phase 3
Study type: Interventional

The primary objective of this study is to show superiority in the treatment of HMB of vilaprisan in subjects with uterine fibroids compared to placebo. The secondary objectives of this study are to additionally evaluate the efficacy and safety of vilaprisan in subjects with uterine fibroids.

NCT ID: NCT03399097 Not yet recruiting - Obesity Clinical Trials

Characterizing the Intestinal Hormonal Secretion in Non-obese, Obese and Non-obese Patients After Bariatric Surgery

Start date: January 2018
Phase: N/A
Study type: Observational

The enteroendocrine system is composed from different cells along the different parts of the gastrointestinal tract, secreting diverse hormones and bariatric surgery alters intestinal hormone secretion, affecting glycemic control and weight. The aim of the study is to characterize the composition and secretory profile of enteroendocrine cells in the obese, non-obese and non-obese post bariatric surgery.

NCT ID: NCT03398928 Recruiting - Delirium in Old Age Clinical Trials

Delirium Treatment With Acupuncture in Internal Medicine Departments

Start date: January 1, 2017
Phase: N/A
Study type: Interventional

Delirium frequently occurs in hospitalized older people, and treatment options are limited. Acupuncture has been shown to reduce agitation in the setting of dementia. The investigators will test the hypothesis that it may also assist in treating delirium.

NCT ID: NCT03398655 Recruiting - Clinical trials for Recurrent Platinum Resistant Ovarian Cancer

A Study of VB-111 Combined With Paclitaxel vs. Paclitaxel for Treatment of Recurrent Platinum-Resistant Ovarian Cancer (OVAL)

OVAL
Start date: December 19, 2017
Phase: Phase 3
Study type: Interventional

The purpose of this phase 3, randomized, multicenter study is to compare VB-111 plus paclitaxel to paclitaxel in adult patients with Recurrent Platinum-Resistant Ovarian Cancer.

NCT ID: NCT03398577 Not yet recruiting - Clinical trials for Coronary Disease With Diabetes Mellitus

Effects of SGLT2 Inhibitor in Diabetic Patients With Coronary Artery Disease

Start date: February 1, 2018
Phase: Phase 4
Study type: Interventional

The aim of this study is to explore the effect of newly added SGLT2I medication or placebo, to standard medication regimen in diabetic patients with documented stable coronary disease. Therefore, in the present study the investigators plan to focus on possible anti-inflammatory and athero-thrombotic protective effects of Dapagliflozin compared to placebo, in secondary prevention population of stable coronary patients with diabetes. Additionally, the investigators will explore NT proBNP dynamics, which related to ventricular filling pressures in this specific population.

NCT ID: NCT03398213 Recruiting - COPD Exacerbation Clinical Trials

Acupuncture Treatment of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation

Start date: November 25, 2017
Phase: N/A
Study type: Interventional

Chronic obstructive pulmonary disease (COPD) is a major health problem. Acute exacerbations are a health-care burden involving frequent hospitalizations and elevated costs. They have effective therapies with significant side effects. Acupuncture has been shown to reduce dyspnea and other COPD-related symptoms. The investigators will compare the efficacy and safety of the addition of true acupuncture to usual care with both sham-acupressure added to usual care and usual care only for the treatment of acute exacerbations of COPD among inpatients.