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NCT ID: NCT05436015 Recruiting - Pain Clinical Trials

Effectiveness of Virtual Nature-based Intervention During First Stage of Labour

Start date: March 1, 2022
Phase: N/A
Study type: Interventional

Rationale: The birth environment effects on childbirth experience and feelings of security of birthing women. Fear of Childbirth (FOB) is experienced by 6-10% of women in Finland and FOB predicts postpartum depression. Real or artificial views of nature have several positive health effects including reduction of anxiety and stress. Feasible and cost-effective nature-based intervention is being studied in this pilot RCT. Objectives: To develop a virtual nature-based intervention for the delivery ward and to assess its feasibility and effectiveness. The study assesses how the nature-based intervention carried out during the first stage of labour affects the anxiety, fear, stress, pain and childbirth experience of birthing women. The aim is to provide evidence-based information on the feasibility and effectiveness of this intervention. Methods: Sixty women will be randomized into two groups: Nature-based intervention group and control group. All participants will have assessments during first stage of labour in nature-based intervention group before and after intervention and in control group at the same time without intervention. In both groups also 2-6 hours after childbirth, 2 days after childbirth and 2 weeks after childbirth.

NCT ID: NCT05435703 Completed - Clinical trials for Primary Aldosteronism

Renal Cysts and Primary Aldosteronism

Start date: October 7, 2020
Phase:
Study type: Observational

During routine subtyping of confirmed primary aldosteronism by adrenal vein sampling extra plasma samples are drawn from both renal veins and from inferior vena cava. Plasma renin concentration and renin activity are analysed from these samples. Adrenal computed tomographies are analysed for cysts and other possible pathology by a blinded radiologist. Aim is to evaluate correlation between renal pathology and renin measurements.

NCT ID: NCT05428969 Recruiting - Clinical trials for Acute Myeloid Leukemia

A Study to Assess Safety, Tolerability and Preliminary Efficacy of Bexmarilimab in Combination With Standard of Care in Patients With Hematological Malignancies (BEXMAB)

Start date: June 2, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

This is a study to assess the safety of increasing dose levels of bexmarilimab when combined with standard of care (SoC) in patients with myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) or acute myeloid leukemia (AML); Phase 1 aims to identify the recommended phase 2 dose (RP2D) of bexmarilimab based on safety, tolerability and pharmacological activity; Phase 2 will investigate the preliminary efficacy of the combination treatment in selected indications from Phase 1.

NCT ID: NCT05426265 Not yet recruiting - Clinical trials for Major Depressive Disorder

The Effects of Videogames on Depression Symptoms and Brain Dynamics

Start date: July 1, 2022
Phase: N/A
Study type: Interventional

The purpose of the study is to evaluate the effects of a game-based digital-therapeutics (DTx) medical software device on the symptoms of depression in adults with confirmed major depressive disorder.

NCT ID: NCT05425784 Not yet recruiting - Periodontitis Clinical Trials

Home Use of Dual-light Photodynamic Therapy for Chronic Periodontitis

Start date: August 1, 2022
Phase: N/A
Study type: Interventional

This early-stage research is designed to determine the efficacy of the Lumoral method in chronic periodontitis patients. Improved supragingival plaque control can help to also sustain the subgingival plaque management in the long term. In addition, the device might have a photobiomodulation effect on periodontal tissues.

NCT ID: NCT05413733 Not yet recruiting - Clinical trials for Traumatic Brain Injury

Neuropsychological Rehabilitation Over the Internet

IRENE
Start date: June 13, 2022
Phase: N/A
Study type: Interventional

Helsinki University Hospital (HUS) has decided on a strategy to provide digital health care services for several medical specialties - a project called the Health Village (HealthVillage.fi). Within Health Village a specific digital My Path program, iRENE Digital Pathway, has been developed for web-based neuropsychological rehabilitation. iRENE Digital Pathway is a structured program for adults with an acquired brain injury (ABI), which utilizes psychoeducative information and self-evaluation questionnaires for attentional, memory and executive disorders with a feedback, and provides training for internal and external memory and other cognitive strategies. The current study will explore if web-based neuropsychological rehabilitation is a feasible and effective method for carrying out rehabilitation for adults with ABI.

NCT ID: NCT05403671 Not yet recruiting - Cancer Survivor Clinical Trials

Fit for Everyday Life - Increasing Exercise and Physical Activity in Those Rehablilitating From Cancer

Start date: September 1, 2022
Phase: N/A
Study type: Interventional

The aim of the study is to increase the physical activity and exercise of those recovering from cancer (after treatments) and to promote a functional return to everyday life and coping in everyday life. The aim of the study is to evaluate the effects of a exercise intervention on the quality of life, functional fitness (functional muscle strength and endurance tests) and the amount of physical activity of the participants in the study.

NCT ID: NCT05401201 Not yet recruiting - Dental Plaque Clinical Trials

Dual-light Antibacterial Photodynamic Therapy as an Adjunctive Treatment to Triamcinolone in OLP

Start date: August 1, 2022
Phase: N/A
Study type: Interventional

This study is designed to investigate the effectiveness of plaque control intervention by home-use dual-light aPDT Lumoral -device as an adjunctive or alternative treatment to triamcinolone acetonide (TCA) mouth rinse on the symptoms and clinical appearance of symptomatic gingival involvement of oral lichen planus (OLP).

NCT ID: NCT05396430 Not yet recruiting - Clinical trials for Cesarean Section Complications

Duration of Urinary Catheter Treatment After Cesarean Delivery Under Spinal Anesthesia

Start date: June 1, 2022
Phase: N/A
Study type: Interventional

In this study a total of 150 parturients undergoing cesarean delivery under spinal anesthesia will be randomized to have their urinary catheters kept in place for 8, 10 or 12 hours. The incidence of urinary retention and interventions needed for any potential urinary retention will be assessed.

NCT ID: NCT05396417 Not yet recruiting - Clinical trials for Cesarean Section Complications

How Well do the Current Cesarean Deliveries Adhere to the Published ERAS Guidelines?

Start date: July 1, 2022
Phase:
Study type: Observational [Patient Registry]

Local guidelines for the postoperative care of women who have undergone cesarean delivery at the HUS/Women's hospital are based recommendations by the ERAS society. This study will take a prospective sample of 500 parturients who have gone through a cesarean delivery and their care will be verified against the local check-list for cesarean delivery.