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NCT ID: NCT03197597 Completed - Clinical trials for Bordetella Pertussis, Whooping Cough

EUpertstrain 4 Study of Bordetella Pertussis Isolates

Start date: October 12, 2015
Phase: N/A
Study type: Observational

This study focus on the genetic changes of B. pertussis clinical isolates. For this panels of B. pertussis isolates has been collected during four periods in different European countries.

NCT ID: NCT03196453 Not yet recruiting - Overweight Clinical Trials

Fit Child - Clinical Study on Weight Control

Start date: August 1, 2017
Phase: N/A
Study type: Interventional

Children with abnormal weight development of BMI will be given either placebo or a probiotic protein formula and measures of weigh gain during a 3-mont treatment will be conducted

NCT ID: NCT03194646 Not yet recruiting - Leiomyoma Clinical Trials

Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids

Start date: June 30, 2017
Phase: Phase 3
Study type: Interventional

The study is performed to assess the efficacy and safety of Vilaprisan in subjects with uterine fibroids compared to standard of care

NCT ID: NCT03192813 Recruiting - Clinical trials for Aortic Valve Stenosis

Safety and Efficacy Comparison Of Two TAVI Systems in a Prospective Randomized Evaluation II

Start date: April 20, 2017
Phase: N/A
Study type: Observational

Current care randomized clinical trial comparing the CE marked Symetis ACURATE neo™ Aortic Bioprosthesis and ACURATE TF™ Transfemoral Delivery System with the CE marked Medtronic CoreValve Evolut R TAVI system (or any future CE-marked CoreValve versions). The collected data will also be used to apply for regulatory approval in France by HAS (Haute Autorité de Santé).

NCT ID: NCT03192020 Not yet recruiting - Clinical trials for Dupuytren Contracture

Trial Comparing Treatment Strategies in Dupuytren's Contracture

Start date: August 14, 2017
Phase: Phase 4
Study type: Interventional

Trial is a prospective, randomized, controlled, outcome assessor-blinded, three armed parallel 1:1:1, multicenter trial. The research objective is to determine, which treatment strategy 1) primary percutaneous needle fasciotomy (PNF) followed by surgical limited fasciectomy (LF) in patients who do not respond to PNF, 2) primary collagenase clostridium histolyticym (CCH) followed by LF in patients who do not respond to CCH or 3) LF as the primary (and secondary) treatment modality is the most efficacious and cost-effective in treating Dupuytren´s contracture.

NCT ID: NCT03191799 Not yet recruiting - Hemophilia A Clinical Trials

A Study to Evaluate the Safety and Tolerability of Prophylactic Emicizumab in Hemophilia A Patients With Inhibitors

Start date: July 27, 2017
Phase: Phase 3
Study type: Interventional

This is a phase IIIb, single arm, open-label, multi-center study to evaluate the safety and tolerability of emicizumab in participants with congenital hemophilia A who have documented inhibitors against Factor VIII (FVIII) at enrollment. Approximately 200 participants, aged 12 or older, will be enrolled in this study and are expected to be enrolled at approximately 85 sites globally. Participants will receive an initial weekly dose of prophylactic emicizumab subcutaneously for 4 weeks, followed by a weekly maintenance dose subcutaneously for the remainder of the 2-year treatment period.

NCT ID: NCT03191396 Not yet recruiting - Diabetes Clinical Trials

Research Study Comparing a New Medicine Semaglutide to Liraglutide in People With Type 2 Diabetes

Start date: June 25, 2017
Phase: Phase 3
Study type: Interventional

This study is conducted in Europe. The aim of the study is to compare the effect of semaglutide subcutaneous (s.c., under the skin) 1.0 mg once-weekly to liraglutide s.c.1.2 mg once-daily on blood sugar levels after 30 weeks of treatment in people with type 2 diabetes. The study will last approximately 9 months (37 weeks). Each participant will have 7 visits at the clinic and 3 phone calls with the study doctor. At the visits, participants will have a number of tests, for example: general health checks, blood samples, heart and eye checks etc. Participants will also fill in some forms about their health and satisfaction with their diabetes treatment.

NCT ID: NCT03191331 Recruiting - Clinical trials for Gestational Diabetes

Dietary Intervention, Gestational Weight Gain and Gestational Diabetes.

Start date: June 6, 2017
Phase: N/A
Study type: Interventional

The aim of this pilot study is to conduct a dietary intervention for overweight (body maas index BMI≥25) and obese (BMI≥30) pregnant women in two maternity care clinics and explore the effect of the intervention on gestational weight gain and the prevalence of gestational diabetes between the intervention and control groups.

NCT ID: NCT03189576 Recruiting - Colorectal Cancer Clinical Trials

Measuring Molecular Residual Disease in Colorectal Cancer After Primary Surgery and Resection of Metastases

Start date: October 1, 2015
Phase: N/A
Study type: Interventional

Circulating tumour DNA (ctDNA) is a promising tool when monitoring the residual disease in colorectal cancer (CRC). Current staging procedures are insufficient to identify the patient cohort at high risk, who might benefit from additional adjuvant therapy. We will show that the assessment of ctDNA is a non-invasive approach and easily taken at different time points via simple blood draw to monitor residual disease from the colorectal cancer patients after primary surgery. Minimal residual disease could be used in the future for individualized treatment decisions after primary surgery.

NCT ID: NCT03186989 Recruiting - Clinical trials for Mild Alzheimer's Disease

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IONIS-MAPTRx in Patients With Mild Alzheimer's Disease

Start date: June 5, 2017
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose is to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of IONIS-MAPTRx in patients with Mild Alzheimer's Disease