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NCT ID: NCT03806049 Not yet recruiting - Ovarian Cancer Clinical Trials

Trial Comparing Niraparib-bevacizumab-TSR042 and Niraparib-bevacizumab to Standard of Care in Recurrent Ovarian Cancer

Start date: June 2019
Phase: Phase 3
Study type: Interventional

NSGO / AVANOVA-Triplet: This three-arm randomized trial is to demonstrate efficacy of niraparib-bevacizumab-TSR-042 triplet combination against standard of care treatment and to demonstrate efficacy of niraparib-bevacizumab-TSR-042 triplet combination against niraparib-bevacizumab doublet combination for patients with platinum-sensitive epithelial ovarian, fallopian tube, or peritoneal cancer

NCT ID: NCT03799939 Not yet recruiting - Clinical trials for Rectal Adenocarcinoma

Chimney Trial of Parastomal Hernia Prevention

Start date: January 2019
Phase: N/A
Study type: Interventional

Chimney trial is designed to compare the effectiveness and safety of specifically designated polyvinylidene fluoride mesh (PVDF, Dynamesh IPST) to controls in a multi center, randomized setting.

NCT ID: NCT03795064 Recruiting - Venous Ulcer Clinical Trials

Immediate Versus Early Endovenous Ablation In Venous Ulcer

Start date: December 5, 2018
Phase: N/A
Study type: Interventional

The study is conducted to assess the effects of immediately started foam sclerotherapy in venous ulcer compared to early intervention.

NCT ID: NCT03785847 Recruiting - Clinical trials for Respiration Disorders

Normal Variability of Tidal Breathing Flow-volume Curves During Sleep in Healthy Children

Start date: December 20, 2018
Phase:
Study type: Observational

The study includes a comprehensive health examination with focus on respiratory health and the TBFV recordings using impedance pneumography (Ventica®) during sleep at night in healthy children.

NCT ID: NCT03783234 Recruiting - Aged Clinical Trials

Triage Assessment and NEWS-score as Risk Predictor in Older Frailty Adults in the ED

Start date: December 11, 2018
Phase:
Study type: Observational

Emergency Department Triage Systems have not been shown to sufficiently recognize frail elderly patients in need of urgent assessment and care. In this prospective, observational study the performance of the 3-level triage system and the National Early Warning Score (NEWS) 2 are assessed (separately and combined) for predicting adverse outcomes in older frailty patients visiting in the ED. Observational data for this study is gathered as part of GAOPS - main study (ClinicalTrials.gov Identifier: NCT03751319).

NCT ID: NCT03775538 Recruiting - Parkinson Disease Clinical Trials

Safety of CDNF by Brain Infusion in Patients With Parkinson's Disease. Extension to HP-CD-CL-2002 Clinical Study

Start date: July 5, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

This study is an extension to the HP-CD-CL-2002 clinical study. It evaluates the long-term safety and tolerability of CDNF in patients with Parkinson's disease when dosed directly into the brain using an implanted investigational drug delivery system (DDS). Long-term safety of the DDS is also being evaluated. All patients will receive monthly infusions of either mid- or high-dose of CDNF for a period of 6 months.

NCT ID: NCT03774303 Recruiting - Pain Clinical Trials

Effectiveness of Mobile Application Intervention in Day Surgery

Start date: January 19, 2018
Phase: N/A
Study type: Interventional

In Finland about 50% of surgical operations for all under 16 years of age are made as day surgery which means that the patient comes to the hospital and is discharged on the day of the operation. Day surgery will continue to grow in the next few years. Its benefits include shorter hospitalization, family reunion and rapid recovery. The preschool children and their parents who come in for day surgery feel fear, anxiety and stress, which depend on the amount of knowledge and its quality. By developing the preparation of preschool children and their parents for day surgery, and by testing new methods more attention can be paid to the special features of day surgery, supporting the families, and increasing family involvement in the whole process. The purpose of this study is to describe and evaluate the effectiveness of a new mobile application intervention compared to the effectiveness of the traditional preparing method when measuring preschool children's fear and pain and their parents' anxiety and stress. The aim is to produce new information and to develop day surgery of preschool children. The study consist of two phases. The first phase of the research is a systematic literature review and meta-analysis. The purpose of the review is to assess and describe the methods previously used in the preparation of parental day surgery and their effectiveness for preschool children fear and pain and parents' anxiety and stress. The second phase of the study is carried out as a randomized controlled trial (=RCT). The parents of the preschool children are randomized to the mobile application group (n = 50-60) and the control group (n = 50-60). The sample size is based on power-analysis, with anxiety as the primary outcome. The material for the second phase of the study is collected at the day surgery department of the Oulu University Hospital. The study group is prepared for day surgery with a new mobile application and the control group according to the traditional preparing method. The study examines the effectiveness of a new intervention compared to the effectiveness of the traditional preparing method when measuring preschool children's fear and pain and their parents' anxiety and stress. The collected data are analyzed using the Mann-Whitney, t-test, Khi square test, and Fisher's accurate test.

NCT ID: NCT03765684 Not yet recruiting - Pregnancy Related Clinical Trials

Factors Affecting Newborn Body Composition and Later Health in Helsinki Birth Cohort 2018-2020

HeBiCo
Start date: December 1, 2018
Phase:
Study type: Observational

In Helsinki BIrth Cohort 2018-2020 a large, longitudinal and well-phenotyped birth cohort of infants and their parents will be established. All the children born in Helsinki Women's Hospital and Espoo hospital (15 000 annual deliveries), their mothers and fathers will be recruited in the study. Data on maternal and paternal diet quality, physical activity and depression during pregnancy will be collected. Newborn body composition will be measured and registry data will be collected. Health of offspring will be followed during their later life.

NCT ID: NCT03759314 Recruiting - Malnutrition Clinical Trials

Identification of Risk Patients in Emergency Medical Services

Start date: September 1, 2018
Phase:
Study type: Observational

Background: Inadequate nutrition has been associated with growing risk of falling and impaired ability in elderly patients. Falling is a significant threat to the health of the elderly. It is estimated that one third of people over the age of 65 experience at least one falling each year. Over 60% of the falls cause serious injury or disability. Adequate nutrition increases the muscle strength of the elderly. Therefore, determining and managing the nutrition level is important for preventing falling. As far as we know emergency medical services has never before reported being a part of prevention by performing risk identification.

NCT ID: NCT03757455 Not yet recruiting - Pancreatic Cancer Clinical Trials

ERAS Protocol in Pancreaticoduodenectomy and Total Pancreatectomy

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

In the study, the enhanced recovery after surgery (ERAS) program is applied to total pancreatectomy (TP) and low-risk pancreaticoduodenectomy (PD) patients identified by a small number of acinar cells in the cut edge of the pancreas. The research setting is randomized and controlled. All patients arriving at the Tampere University Hospital (TAUH) for PD or TP surgery are recruited into the study. Recruited patients are randomized to the ERAS protocol and to the standard protocol recovery program. The ERAS program differs from the normal care protocol preoperatively, intraoperatively and postoperatively as explained in the following section. In the ERAS protocol, both on the previous day of the surgery and on the following days, the patient is discussed with the patient about the benefits of the protocol used and the recovery program objectives. The purpose is to motivate and encourage the patient. On the day of surgery, the patient's intake of food and fluids is allowed to be closer to the surgery and the patient is also given a carbohydrate drink two hours before surgery. The nasogastric tube set at the beginning of surgery is removed at the end of the surgery and peripancreatic or perihepatic drains are not routinely placed. After surgery, drinking is allowed after four hours and the patient is encouraged to move as actively as possible in the bed. On the first and second postoperative day, the patient is allowed to enjoy normal food and drink according to his or her ability, and pancreatic capsules are given in the course of food. Additionally, the analgesic to be administered through the epidural cannula is dosed as far as possible to allow mobilization of the patient. The discussion on the benefits and recovery targets of the ERAS protocol are continued. On the third postoperative day, the epidural infusion is discontinued and the pain medication is moved to opioid-based pain management. This is continued until specific criteria for passing to the follow-up care are met. Typical complications (pancreatic fistula, delayed gastric emptying, postpancreatectomy hemorrhage) are registered during hospitalization and their severity ratings according to ISGPS, ISPGF and Clavien-Dindo classifications are also determined. Other variables registered are the number of intensive care days, situations requiring new surgeries, 30 and 90 day mortality, the completion time of the criteria for passing to follow up care, and the total length of hospitalization. In addition, the need for readmissions is registered. The implementation of the ERAS protocol is followed by a separate tracking template, in which the nurses record the progress of the goals specified in the protocol on a daily basis. The results of the study are analyzed with the intention-to-treat principle.