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NCT ID: NCT06434142 Completed - Stress Disorder Clinical Trials

Wear Assessment of Novel PEEK Telescopic Attachment for Overdenture

Start date: February 11, 2024
Phase: N/A
Study type: Interventional

To assess the wear of Zirconia-PEEK versus cobalt-chromium-PEEK telescopic attachments for implant retained complete mandibular overdenture. The wear of Zirconia-PEEK telescopic attachments can affect the retention of implant retained complete mandibular overdenture.

NCT ID: NCT06433713 Completed - Postoperative Pain Clinical Trials

Effect of Intraoperative Intravenous Lidocaine on Postoperative Pain and Return of Bowel Function After Cesarean Sections

Start date: December 1, 2023
Phase: Phase 2
Study type: Interventional

Postoperative discomfort is a frequently seen adverse event after to caesarean operation. Early mobilization and bonding of the mother and her infant are typically impacted by this phenomenon. Nevertheless, the current state of postoperative analgesia and recovery remains inadequate in clinical settings. In the context of major abdominal surgery, opioids are often regarded as the preferred postoperative analgesic. Nevertheless, they possess adverse side effects that might impact the process of recuperation after surgery. These symptoms include nausea and vomiting, decreased bowel movement, and shallow breathing. One additional challenging consequence after surgery is the delayed restoration of bowel function, which has the potential to extend the duration of hospitalization and impede the initiation of oral feeding, resulting in gaseous colonic distension. The administration of lidocaine infusion has been shown to possess analgesic, anti-hyperalgesic, and anti-inflammatory characteristics. The use of intravenous lidocaine after surgery is postulated to have the dual effect of mitigating postoperative pain and expediting the resumption of bowel movements. Recent studies have shown that the administration of intravenous lidocaine, either as a single dosage or by continuous infusion, may have potential advantages in maintaining gastrointestinal motility and exerting an impact on biochemical pain mechanisms. However, the literature presents contradictory data about the effectiveness of lidocaine in providing sufficient postoperative pain relief and reducing postoperative ileus. Consequently, this study was conducted and aimed to assess the effect of intravenous intraoperative lidocaine on postoperative pain and early return of bowel function following elective caesarean section. This randomized clinical trial was conducted at Obstetrics and Gynecology Department, Faculty of Medicine, Cairo University Hospitals from August till December 2023. A total of 60 pregnant women underwent elective caesarean section were enrolled and randomized into two groups; experimental group who received IV infusion of lidocaine starting with skin incision, which was maintained until skin closure and control group who received 0.9% normal saline at the same rate as that described in the experimental group. Both groups were compared as regard total operative time, medications given, start-stop time of the study drug infusion, and degree of pain using visual analogue scale, need for analgesics, time for first healing of normal intestinal sounds and time to first flatus and symptoms of lidocaine toxicity were recorded.

NCT ID: NCT06432413 Completed - Colorectal Cancer Clinical Trials

Emerging Role of NOTCH-related Long Non-coding RNA(s) as Biomarkers in Liquid Biopsy From Colorectal Cancer Patients

Start date: June 1, 2021
Phase:
Study type: Observational

This work aims to Investigate the role of circulating notch associated lncRNAs SNHG3 and LUNAR1 as possible non invasive prognostic biomarkers for colorectal cancer (CRC) monitoring via measuring the gene expression level of lncRNAs SNHG3 and LUNAR1 in serum of CRC patients compared with control subjects. Also, to investigate the correlation between SNHG3 and LUNAR1 expression levels and CRC clinicopathological features and their relevance for CRC patients' clinico-pathological features outcomes assessment

NCT ID: NCT06432049 Completed - Clinical trials for Comparing Different Types of Restorations for Restoring Endodontically Treated Permanent First Molar in Children

Endocrown Restoring First Permanent Molar in Children

Start date: December 5, 2022
Phase: N/A
Study type: Interventional

Clinical and radiographic evaluation of endodontically treated first permanent molars in thirty children restored with three different restorations over 12 months

NCT ID: NCT06431568 Completed - Cesarean Section Clinical Trials

Ondansetron Prior Spinal Anaesthesia

Ondansetron
Start date: October 1, 2023
Phase:
Study type: Observational [Patient Registry]

Since Ondansetron is commonly used during cesarean deliveries to treat nausea and vomiting, this study will observe the correlation between ondansetron administration and effect on hemodynamics in order to confirm that the use of Ondansetron can reduce incidence of hypotension and bradycardia associated with spinal in cesarean section, and to identify the optimal timing and dose for administration.

NCT ID: NCT06430944 Completed - Femur Fracture Clinical Trials

Comparative Study Between Single and Double Limb Hip Spica Cast in Fracture Femur in Young Children

Start date: May 1, 2022
Phase: N/A
Study type: Interventional

We performed a randomized control trial including 84 children aged two to six years who presented with femoral fractures. They were randomized into two groups; the first was managed by single limb cast fixation (42 patients), and the second was managed by double limb cast fixation (42 patients). The primary outcomes were postprocedural functional outcomes and parents' satisfaction, while the secondary outcomes were the rates of complications.

NCT ID: NCT06430710 Completed - Deep Overbite Clinical Trials

Tooth Borne Versus Temporary Anchorage Devices (TAD) Based Intrusion Systems for the Correction of Anterior Deep Overbite

Start date: September 25, 2022
Phase: N/A
Study type: Interventional

Compare the tooth borne versus fixed orthodontic intrusive system (TADs) for the correction of anterior deep overbite

NCT ID: NCT06428916 Completed - Clinical trials for Respiratory Distress Syndrome

Facilitated Tucking Position During Endotracheal Suctioning

Start date: December 1, 2022
Phase: N/A
Study type: Interventional

Aim of the present study The present study will aimed to determine the effect of facilitated tucking position during endotracheal suctioning on physiological criteria and behavioural responses of the preterm neonates. Research Hypotheses 1. Preterm neonates who receive facilitated tucking position during endotracheal suctioning exhibit more stable physiological criteria than those who do not. 2. Preterm neonates who receive facilitated tucking position during endotracheal suctioning exhibit more stable behavioral responses than those who do not.

NCT ID: NCT06428474 Completed - Dental Caries Clinical Trials

Implementation of Oral Health Educational Program on Orphan Children

Start date: September 1, 2023
Phase: N/A
Study type: Interventional

Oral diseases are most prevalent among children. Orphans children are one of the most vulnerable groups to diseases especially oral diseases. Knowledge toward oral cavity and oral hygiene measures is low among this group, leading to poor practice of oral hygiene measures, which outcomes to oral diseases. Implementation of health education program orphan children who are living in orphanages is important. the aim of this study is to evaluate the effectiveness of health education program on the knowledge and practice of orphan children. 80 children were enrolled in this study from different orphanages in Alexandria, Egypt. Knowledge and practice were evaluated before and after intervention using predesigned questionnaire, and oral hygiene was evaluated using simplified oral hygiene index

NCT ID: NCT06428318 Completed - Pneumonia Clinical Trials

Diagnostic Value of the Biofire®in Community Acquired Pneumonia

Start date: May 15, 2023
Phase: N/A
Study type: Interventional

This study aimed to determine the impact value of the BioFire FilmArray Pneumonia panel compared to conventional sputum culture in critically ill patients with pneumonia.