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NCT ID: NCT06336109 Recruiting - Healthy Clinical Trials

Fragmented Sleep, Pain, and Biomechanics

Start date: January 26, 2024
Phase: N/A
Study type: Interventional

This interventional study aims to test the effects of sleep disruption on pain sensitivity and biomechanics in healthy individuals during experimental knee and shoulder pain. The main question the study aims to answer is: 1) Does sleep fragmentation increase experimental knee and shoulder pain and what are the underlying mechanisms? Participants will receive two injections a) Hypertonic saline (painful) in the knee and b) hypertonic saline (painful) in the upper arm.

NCT ID: NCT06335420 Not yet recruiting - Clinical trials for Colorectal Cancer Prevention

Prophylactic Properties of Carrot Juice in Patients With High-Risk Colorectal Polyps

Px7
Start date: April 2024
Phase: N/A
Study type: Interventional

The goal of this prospective randomized double-blinded bi-national study is to test the prophylactic effect of polyacetylenes from carrots on the population of patients who had a resection of high-risk adenomas of the large bowel. The main question it aims to answer is: Will carrot juice rich in polyacetylenes inhibit neoplastic transformation and growth in high-risk humans? Participants will have to drink 100 ml of juice daily after the adenoma resection for 1 year and keep a simple diary/calendar. Researchers will compare the group with ingestion of FaOH/FaDOH rich carrot juice versus the group consuming placebo juice, to see if the polyacetylenes significantly reduces neoplastic transformation and growth in high-risk patients.

NCT ID: NCT06334653 Not yet recruiting - Energy Metabolism Clinical Trials

Exercise-regulated Organ Crosstalk, Influence of IL-6

EVEX
Start date: April 9, 2024
Phase: N/A
Study type: Interventional

Overall the study investigates organ crosstalk during exercise. More specifically, the study investigates the role of IL-6 in regulating glucose, fatty acid, and amino acid kinetics at whole body level and in skeletal muscle, liver, and brain. Furthermore, the study investigates the uptake and release of extracellular vesicles in skeletal muscle, liver, and brain in reponse to exercise.

NCT ID: NCT06334276 Not yet recruiting - Drowning Clinical Trials

Developing an Utstein-style Danish Drowning Registry: Nationwide Fatal and Nonfatal Drowning Data Since 2016

DROWN_INHOS
Start date: January 1, 2025
Phase:
Study type: Observational

This nationwide, registry-based study aims to link Danish Prehospital Drowning Data data with inhospital data to develop a Utstein-style Danish Drowning Registry. This study will report mortality and neurological outcomes 30 days after a drowning incident since 2016.

NCT ID: NCT06334198 Recruiting - Constipation Clinical Trials

The Effect of Naldemedine on Opioid-induced Bowel Dysfunction

Start date: March 12, 2024
Phase: Phase 2
Study type: Interventional

Opioid-induced bowel dysfunction is a frequent condition during opioid therapy for chronic pain. Indeed, up to 90% of people on opioid treated patients experience constipation. Standard laxative treatment is often ineffective in opioid-induced constipation, but peripheral acting mu-receptor antagonists (PAMORAs) have the potential to block the effects of opioids in the gastrointestinal tract while preserving the central analgesic effect. In this study, we will investigated the effects of Naldemedine in preventing the development of opioid-induced bowel dysfunction and constipation during treatment with tramadol

NCT ID: NCT06334172 Recruiting - Clinical trials for Glucose Metabolism Disorders (Including Diabetes Mellitus)

The Role of Oxytocin in Regulating Blood Glucose

GLOXY-1
Start date: January 1, 2024
Phase: N/A
Study type: Interventional

Investigating the effect of oxytocin on pancreatic endocrine functions by determining insulin and glucagon secretion within physiological ranges of plasma glucose.

NCT ID: NCT06334003 Not yet recruiting - IVF Clinical Trials

Cardiometabolic Function in Offspring, Mother and Placenta After Assisted Reproductive Technology

COMPART
Start date: May 1, 2024
Phase:
Study type: Observational

The overall objective is to establish the first-of-its-kind longitudinal cohort of pregnant women, biological fathers/partners and offspring from pregnancies achieved by frozen embryo transfer (FET), fresh-embryo transfer (fresh ET) and naturally conceived (NC) to investigate maternal cardiometabolic profiles, fetal growth patterns and placental function during pregnancy as well as metabolic and endocrine health in the offspring. Additionally, the aim is to explore genetic and epigenetic patterns in placenta, fetus and parents. As secondary objectives, the investigator group will examine telomere length and minipuberty hormones in children born after FET, fresh-ET and NC.

NCT ID: NCT06333847 Active, not recruiting - Low Back Pain Clinical Trials

Are Multimorbidity and Related Factors Associated With Non-response Bias in Patients With Spinal Pain?

Start date: June 1, 2023
Phase:
Study type: Observational

The study aims to explore if non-response bias exists among individuals with chronic back pain, focusing on the impact of chronic disease count, treatment burden from multimorbidity, and health-related quality of life. Data is gathered from patients at Aalborg University Hospital's Rheumatology Department via electronic means and medical records. The analysis comprises two-wave assessments, investigating disparities among patients responding to study invitations based on response patterns: first, second, or third invitation responses. Utilizing baseline data, a one-way ANOVA is employed to detect potential between-group variations in the mentioned factors. Subsequently, a repeated measures ANOVA is conducted to evaluate differences among groups over time. Additionally, statistical analyses are conducted to scrutinize variances in age and gender distribution between respondents and non-respondents to the questionnaire invitations at baseline.

NCT ID: NCT06333795 Not yet recruiting - Diarrhea Clinical Trials

Faecal Microbiota Transplantation Against Chronic Diarrhea in Patients With Systemic Sclerosis

FaeMiCue
Start date: April 1, 2024
Phase: N/A
Study type: Interventional

This clinical trial aims to assess the safety and effectiveness of faecal Microbiota Transplantation (FMT) in improving chronic diarrhea symptoms among patients with systemic sclerosis.

NCT ID: NCT06333080 Recruiting - Clinical trials for Diabetes Mellitus, Type 2

The Effect of Adherence to Oral Semaglutide on Glycaemic Control in People With Type 2 Diabetes Treated With Metformin

DIACRON
Start date: May 1, 2024
Phase:
Study type: Observational

The objective of the trial is to investigate the effect of adherence to oral semaglutide dosing instructions on glycaemic control in people with type 2 diabetes, which are dysregulated on metformin and naïve to second line antidiabetic treatment.