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NCT ID: NCT03587935 Recruiting - Colonoscopy Clinical Trials

A Clinical Validation Study of a Computerized Movement Analysis of the Colonoscope

Start date: July 12, 2018
Phase:
Study type: Observational

Colonoscopy is the considered gold standard for diagnosing diseases in the colon. A colonoscopy is normally divided into the insertion from anus to cecum, the technical difficult part, and a retraction or diagnostic part. No objective measure exists to evaluate the performance of a colonoscopy. Based on a movement analysis of the colonoscope we wish to seek evidence for an automated and objective system able to differentiate between endoscopists with various experience in a clinical setting. The movement analysis is based on information's from the colonoscope. Electromagnetic coils are built in along the length of colonoscopes. They generate a pulsed magnetic field that is picked up a receiver coil. The data-points for each coil are inserted into an algorithm for the movement analyzing. This analysis is done as a change between the tip of the scope, and the next tracked magnetic coil. The result is a relative movement of the colonoscope in relation to the previous position. The study is conducted a three different University Hospitals in Denmark. Twenty physicians with experience in colonoscopy are voluntary included. Patients appointed to a screening colonoscopy are included and a minimum of five consecutive colonoscopies are recorded for each physician. We predict the system to be automated and objective tool correlated with the physician's technical level of expertise in clinical colonoscopy.

NCT ID: NCT03587220 Not yet recruiting - Neuropathic Pain Clinical Trials

A Mechanistic Evaluation of the Nociceptive Desensitizing Properties of Topical Capsaicin

Start date: August 1, 2018
Phase: N/A
Study type: Interventional

The aim of this project is to study the role of transient receptor potential (TRP-) channel V1 (TRPV1+) fibers in the development of cutaneous inflammation induced by epidermal Ultraviolet-B damage. Moreover, in this project the investigators want to evaluate if the capsaicin-desensitization action can still be induced in a skin area pretreated with topical, local anesthetic lidocaine.

NCT ID: NCT03586310 Recruiting - Sleep Monitoring Clinical Trials

Evaluation of the Ear-EEG System for Sleep Monitoring in Healthy Subjects

Start date: March 23, 2018
Phase: N/A
Study type: Interventional

Subjects sleep multiple nights in their own home, wearing actigraph, PSG (PolySomnoGraphy) and ear-EEG sensors. The object of the study is to determine the applicability of ear-EEG for sleep monitoring.

NCT ID: NCT03585933 Not yet recruiting - Clinical trials for Aortic Stenosis, Calcific

Prognostic Value of Myocardial Fibrosis in Severe Aortic Valve Stenosis

FIB-AS
Start date: September 2018
Phase:
Study type: Observational

Degenerative aortic valve stenosis (AS) is the most common valve heart disease in the developed Western countries. The hemodynamic progression of AS occurs over time and leads to LV hypertrophy (LVH) as a compensation mechanism of the heart. Morphological changes such as increasing muscle fibre thickness, collagen volume, and interstitial fibrosis occur in AS patients. These changes result in left ventricular (LV) diastolic and systolic dysfunction and, consequently, to with AS related symptoms. When symptoms associated with AS appear, patients' prognosis is poor if surgical aortic valve replacement (SAVR) or a trans-catheter aortic valve implantation (TAVI) is not performed. Primary hypothesis of the research: fibrotic changes in the myocardium are related to immediate (in hospital) or long-term complications (MACE and all-cause mortality) in patients with severe AS. The goal of the study is to determine the prognostic implications of focal as well as diffuse myocardial fibrosis in patients with severe aortic valve stenosis.

NCT ID: NCT03585894 Not yet recruiting - Headache Clinical Trials

The Role of Inflammation and Vasodilatation in PACAP38-induced Headache Using MRI on Healthy Subjects

Start date: August 1, 2018
Phase: N/A
Study type: Interventional

Studying Pituitary adenylate cyclase-activating peptide 38 (PACAP38) induced headache effects on extra- and intracerebral arteries and treated by sumatriptan and ketorolac assessed by magnetic resonance imaging (MRI) on healthy volunteers.

NCT ID: NCT03584659 Not yet recruiting - Bladder Cancer Clinical Trials

Patient-reported Outcomes in Bladder Cancer

iBLAD
Start date: September 15, 2018
Phase: N/A
Study type: Interventional

Electronic reporting of patient-reported outcomes with alert algorithm will be tested in a randomized trial in bladder cancer patients undergoing chemo- or immunotherapy. The clinical endpoints will be: - Quality of life - Completion of treatment - Hospital admission - Dose reductions - Survival

NCT ID: NCT03584061 Recruiting - Herpes Zoster Clinical Trials

Treatment of Chronic Postherpetic Pain With Fat Grafting

Start date: May 1, 2018
Phase: N/A
Study type: Interventional

This study evaluates the possible beneficial effect of fat grafting for post herpetic neuralgia.

NCT ID: NCT03583229 Recruiting - Clinical trials for Platelet Dysfunction

Coronary Artery Disease After Heart Transplantation

ECP
Start date: October 13, 2016
Phase: N/A
Study type: Interventional

This study evaluates coronary artery disease after heart transplantation and its relation to platelet function. Furthermore, we will evaluate extracorporeal photopheresis as treatment of coronary artery disease after heart transplantation.

NCT ID: NCT03582631 Recruiting - Inflammation Clinical Trials

Biomarkers in Acute High-risk AbdoMinAl Surgery

BAHAMAS
Start date: June 1, 2013
Phase:
Study type: Observational

Acute high-risk abdominal surgery (AHA) is performed in hospitals worldwide. Ethiologies are heterogeneous, but it carries a high mortality rate (1)(2). In particular, emergency laparotomies performed on elderly people has a high mortality rate(3)(4). Different quality improvement programs have been suggested, but the quality of care and mortality varies between hospitals (5)(6). The use of postoperative intensive care seem to be inadequate for this high risk population (1)(7)(8). It is of paramount importance to identify the frailest and acutely deranged patients, who are in risk of poor outcome, to allocate resources for optimization postoperatively. Failure to escalate care intensity after having developed postoperative complications affect outcome. Organization, teamwork and culture is important postoperatively to be able to escalate care especially in standard care wards (9)(10). However, it is difficult to predict which patients will develop complications. Different risk assessment tools have been proposed for patients undergoing AHA (11)(12). The APACHE-II score, even though developed for critical care, seems to give the best prediction of outcome. Objective risk assessment tools support clinical decision making as subjective clinical assessment often underestimates the risk for the patients in highest risk of complications and death (13). Good clinical decision-making is likely to improve the clinical outcome by allocating appropriate resources. Prognostic tools are also useful to inform patients about what to expect in the postoperative phase and of long-term outcome. Especially in the elder population with increased risk of loss of function or independency, this can be useful to give informed consent to treatment. Furthermore, good risk assessment is important to optimize palliative care after end-of-life decisions, which is often ignored in research, but highly relevant in clinical work. Prognostic biomarkers in other high mortality populations have received much attention for risk stratification (14). An ideal biomarker should be readily available upon decision-making, easy to measure, and reliable. Furthermore, it should accurately differentiate prognosis for patients to have value in the clinical decision-making and guide the treatment. It should also be linked to the clinical outcomes. The investigators aim to identify AHA biomarkers that are prognostic or predictive for postoperative morbidity, mortality and length of hospitalization.

NCT ID: NCT03581773 Recruiting - Mucositis Clinical Trials

Folic Acid Supplement Versus Placebo for Treating Mucositis Adverse Events in Metastatic Renal Cell Carcinoma Patients Receiving Targeted Therapy

FASTERCC
Start date: December 20, 2017
Phase: Phase 2
Study type: Interventional

FASTERCC: Folic acid supplement versus placebo for treating mucositis adverse events in metastatic renal cell carcinoma patients receiving targeted therapy. A randomized, double-blind trial from the Danish renal cancer group (DARENCA study-4)