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NCT ID: NCT03254641 Recruiting - Hypogonadism, Male Clinical Trials

Calciotropic Effects After hCG Stimulation Test

Start date: April 1, 2017
Phase: N/A
Study type: Observational

We have in a pilot study found that serum calcium levels change in response to hCG stimulation test. We observed that serum calcium level measured at baseline and 72 hours after hCG stimulation were different in men with gonadal insufficiency referred for this stimulation test. Now we want to investigate a large cohort of men referred for hCG stimulation test due to suspected impaired gonadal function.

NCT ID: NCT03253276 Recruiting - Clinical trials for Primary Biliary Cirrhosis

Effect of Obeticholic Acid on Transport of Bile Acids in PBC Examined by 11C-cholyl-sarcosine PET/CT

Start date: May 19, 2016
Phase: Early Phase 1
Study type: Interventional

This is an investigator-initiated, double-blind crossover study on the mechanism of OCA treatment of patients with PBC. Hypothesis and significance We will test the hypothesis that OCA administration to patients with PBC increases hepatobiliary secretion of cholylsarcosine assessed by PET/CT using 11C-labeled cholylsarcosine (11C-CSar) as tracer. The results of this research project will elucidate the mechanism of the effect of using OCA therapeutically in patients with PBC.

NCT ID: NCT03252353 Not yet recruiting - Acromegaly Clinical Trials

Efficacy and Safety of Octreotide Capsules (MYCAPSSA) in Acromegaly

Start date: September 1, 2017
Phase: Phase 3
Study type: Interventional

Octreotide capsule is a novel, orally-administered formulation of the commercially-available injectable drug octreotide. In a recent phase 3 trial, oral octreotide capsules demonstrated maintenance of biochemical response up to 13 months in the majority of patients with acromegaly previously managed with somatostatin analog injections (reference below).

NCT ID: NCT03252132 Recruiting - Clinical trials for Diabetes Mellitus, Type 2

Resistance Training in Patients With Diabetic Neuropathy

Start date: August 10, 2017
Phase: N/A
Study type: Interventional

This is a population-based study of type 2 diabetes patients with and without neuropathy recruited from the Danish National Type 2 Diabetes cohort (DD2). Diabetic patients with neuropathy may suffer from incapacitating symptoms such as pain, muscle weakness and impaired balance. Muscle weakness may cause reduced balance and postural instability increasing the risk of frequent falls and thereby increased morbidity and mortality. Thus, diabetic neuropathy is associated with significant disabilities having major impact on activities of daily living and quality of life. The effects of resistance training on neuropathy symptoms, muscle strength and muscle structure in patients with and with diabetic neuropathy will be examined.

NCT ID: NCT03251612 Not yet recruiting - Clinical trials for Colorectal Cancer Metastatic

Predictive Value of Drug Sensitivity Testing Tumorspheres From Patients With Metastatic Colorectal Cancer

Start date: October 2017
Phase: Phase 2
Study type: Interventional

The purpose of the present study is to investigate the benefit of anti-cancer therapy administered on the basis of drug sensitivity testing. This concerns colorectal cancer patients who have previously received standard treatment.

NCT ID: NCT03250195 Recruiting - Fertility Disorders Clinical Trials

Non-invasive Detection of Male Infertility With FDG-PET/MRI (Spectroscopy and DWI)

Start date: August 7, 2017
Phase: N/A
Study type: Interventional

The aim of the study is to examine the value of the new MRI techniques (spectroscopy and DWI), and FDG-PET in prognostication of male infertility.

NCT ID: NCT03248453 Completed - Education, Medical Clinical Trials

Feedback Given by an Automatic and Objective System in Simulated Colonoscopy Increase Learning and Time Spent Practicing

Start date: December 2016
Phase: N/A
Study type: Interventional

The aim is to investigate if feedback given by an automatic and objective system in simulated colonoscopy (the investigation of the large intestine) increase learning and time spent practicing.

NCT ID: NCT03247010 Recruiting - Clinical trials for Castration-resistant Prostate Cancer

Bone Marrow Suppression and Recovery During Radionuclide Treatment

Start date: June 20, 2017
Phase: N/A
Study type: Observational

Radium-223-dichloride is approved therapy for patients with metastatic castration-resistant prostate cancer and bone metastases. Therapy is administered intravenously every 4 weeks for up to 6 cycles. More than 20 % of patients treated at Rigshospitalet develop bone marrow suppression as a side effect to Radium therapy, which delays or excludes the patient from further oncological therapy. Especially thrombocytopenia is a frequent side-effect and can be long lasting. The aim of the study is to examine whether biomarkers of bone marrow recovery (immature platelets, platelet volume, reticulocytes, red cell distribution width) can predict development of hematological toxicity during Radium therapy. Furthermore, to investigate whether these biomarkers can predict recovery from toxicity in patients who develop bone marrow suppression during therapy.

NCT ID: NCT03246464 Recruiting - Myopia Clinical Trials

Clinical Study Of Nearsightedness; TReatment With Orthokeratology Lenses

Start date: March 1, 2017
Phase: N/A
Study type: Interventional

Myopia is a common disease of the eye with increasing prevalence in the Western World as well as in South East Asia where 60-90% of the children are affected. High myopia is associated with an increasing risk of sight threatening complications such as retinal detachment, glaucoma, macular choroidal degeneration and myopic choroidal neovascularization. In myopia the eye is elongated compared to an emmetropic eye. If the elongation of the eye can be controlled the progression of myopia can be controlled. Asian studies have shown reduction in axial length growth by 36-46% in children using orthokeratology contact lenses (OKL). OKL are custom fit, form stable lenses. During sleep the cornea is reshaped creating an emmetropic vision during the day, so no glasses or contact lenses are needed. Twin and family studies have shown a high heritability for the development of myopia, and more than 40 genetic loci have been identified indicating that the effect of OKL in Asian children might not be the same in North European children which is why we want to execute a similar study on North European children. Purpose: 1. Investigate if nightly wear of OKL reduces the progression of childhood myopia (change in axial length) in Danish children when compared to a control group using monofocal glasses. 2. Investigate the safety (Efron score) of OKL. 3. Investigate children's quality of life impact of refractive correction (questionnaire) using OKL compared to glasses. 4. Identify possible predictors for progression of myopia (AC/A ratio, peripheral defocus and higher order aberrations). Method: A randomized controlled 18 months prospective 1:1 study of a group of Danish children. 50 children will be included; 25 in each group. The participants will undergo several measurements reflecting the anatomy and function of the eye at baseline, 6, 12 and 18 month to evaluate the effect.

NCT ID: NCT03246451 Recruiting - Clinical trials for Glucose Metabolism Disorders

The Role of GLP-1 Receptor Signalling in the Glucose-lowering Effect of Metformin in Patients With T2D

Start date: July 1, 2017
Phase: N/A
Study type: Interventional

Delineation of the role of glucagon-like peptide-1 receptor signalling in the glucose-lowering effect of metformin during meal ingestion in patients with type 2 diabetes.