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Clinical Trial Summary

This interventional study aims to test the effects of sleep disruption on pain sensitivity and biomechanics in healthy individuals during experimental knee and shoulder pain. The main question the study aims to answer is: 1) Does sleep fragmentation increase experimental knee and shoulder pain and what are the underlying mechanisms? Participants will receive two injections a) Hypertonic saline (painful) in the knee and b) hypertonic saline (painful) in the upper arm.


Clinical Trial Description

This study will include healthy participants for one baseline session and one follow-up session separated by three nights of experimental sleep disruption. The sleep fragmentation will involve three forced awakenings per night for three consecutive nights between sessions. These awakenings will be planned at 00:00, 02:30, and 05:00. In each session, the participant will answer questionnaires and have their pain sensitivity assessed using cuff-pressure algometry. Following this, they will first receive a painful saline injection into the infrapatellar fat pad of the knee. After a washout period, they will receive another painful saline injection into the deltoid muscle of the shoulder. For both injections, the pain will be rated on an NRS scale (0 representing 'no pain' and 10 representing 'worst pain imaginable') every 30 seconds, and the distribution will be marked on a body chart. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06336109
Study type Interventional
Source Aalborg University
Contact Emma Hertel
Phone +4560887473
Email eh@hst.aau.dk
Status Recruiting
Phase N/A
Start date January 26, 2024
Completion date December 31, 2024

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