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NCT ID: NCT06258642 Not yet recruiting - Clinical trials for Small Cell Lung Cancer Recurrent

Irinotecan Liposome Combined With Anlotinib as Second-line Regimen for SCLC

Start date: February 2024
Phase: N/A
Study type: Interventional

This study is a single arm, multi-center, prospective clinical trial. The purpose of this study is to evaluate the efficacy and safety of liposomal irinotecan combined with anlotinib hydrochloride for relapsed small-cell lung cancer, who have progressed on or less than 6 month after platinum-based first-line therapy.

NCT ID: NCT06258434 Not yet recruiting - Colorectal Cancer Clinical Trials

Liquid Biopsy Based Multiomics Study for Colorectal Cancer Early Screening

COLO-LIMULOID
Start date: February 10, 2024
Phase:
Study type: Observational [Patient Registry]

The primary objective is to determine the diagnostic sensitivity and specificity of the newly developed liquid biopsy based multiomics Colorectal Cancer (CRC) screening test (CRC-Appareo) for detecting advanced neoplasia (including colorectal cancer and advanced adenomas) in high risk patients and patients with confirmed CRC, using colonoscopy as the reference method. The secondary objective is to compare the screening performance of the multiomics Colorectal Cancer (CRC) screening test with commercially available FIT (Fecal Immunochemical Test) assay in detecting advanced neoplasia.

NCT ID: NCT06257966 Not yet recruiting - Clinical trials for Type2 Diabetes Mellitus

A Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Dulaglutide in Combination Therapy Diabetes Mellitus Type 2 Patients With Metformin

Start date: March 1, 2024
Phase: Phase 3
Study type: Interventional

The aim of the study is to compare the efficacy and safety of two JY09 doses versus dulaglutide as add-on therapy to metformin in participants with type 2 diabetes mellitus (T2DM)

NCT ID: NCT06255795 Not yet recruiting - Clinical trials for Extranodal Natural Killer T Cell Lymphoma

The Efficacy and Safety of Chidamide, Anti-PD-1 Antibody in Combination With Pegaspargase Versus DDGP in the Treatment of Newly Diagnosed, Stage III to IV Extranodal Natural Killer/T-Cell Lymphoma

Start date: February 15, 2024
Phase: Phase 3
Study type: Interventional

A multicenter, prospective, randomized, open-label, controlled trial to evaluate the efficacy and safety of chidamide, anti-PD1 antibody, and pegaspargase versus dexamethasone, cisplatin, gemcitabine, and pegaspargase (DDGP) in the treatment of newly diagnosed, stage III to IV extranodal natural killer/T-cell lymphoma.

NCT ID: NCT06255769 Not yet recruiting - Myocardial Ischemia Clinical Trials

Diagnosis of Myocardial Ischemia With MCG Using SPECT as a Reference Standard

Start date: February 12, 2024
Phase:
Study type: Observational

This is a prospective clinical study aiming to investigate the efficacy of Magnetocardiography (MCG) in detecting myocardial ischemia in patients of a suspected non-ST-elevation-acute coronary syndrome (NSTE-ACS) by using Single photon emission computed tomography (SPECT) as the gold standard for determining the presence and severity of myocardial ischemia.

NCT ID: NCT06255704 Not yet recruiting - Clinical trials for Mantle Cell Lymphoma

A Single-arm, Single-center, Open-label Phase II Study of Zanubrutinib Combined With R-CHOP/R-DHAP in Newly Diagnosed Mantle CellLymphoma Patients

Z+RCHOP/RDHAP
Start date: March 15, 2024
Phase: Phase 2
Study type: Interventional

Evaluation the efficacy and safety of Zanubrutinib + R-CHOP/R-DHAP for the treatment mantle cell lymphoma.

NCT ID: NCT06255392 Not yet recruiting - Breast Cancer Clinical Trials

Randomized, Open, Controlled, Multicenter Phase III Clinical Study of Fluzoparib in Combination With Apatinib Versus Investigator-Selected Chemotherapy for HRD-Positive/HER2-negative Advanced Breast Cancer

Start date: February 2024
Phase: Phase 3
Study type: Interventional

This study develops a new therapeutic approach for HER2-negative advanced breast cancer patients without precise treatment targets. The trial aims at extending the combination target therapy involving PARP inhibitors and anti-angiogenesis from only BRCA mutation carriers to all patients with homologous recombination repair defects (HRD-positive). The phase III randomized clinical study will investigate the effectiveness of the combination therapy of PARP inhibitor "fludzoparib" and anti-angiogenic "apatinib" in treating HRD-positive/HER2-negative advanced breast cancers.

NCT ID: NCT06255379 Not yet recruiting - Rectal Cancer Clinical Trials

Study of Fruquintinib Combined With Tegafur Gimeracil Oteracil in Patients With Metastatic Colorectal Cancer

Start date: May 6, 2024
Phase: Phase 2
Study type: Interventional

This is an Open, Single-arm, Multicenter, Prospective Phase II Study of Fuquinitinib Combined With Tegafur Gimeracil Oteracil in the Third-line Treatment of Patients With Advanced Metastatic CRC

NCT ID: NCT06255262 Not yet recruiting - Clinical trials for Biliary Tract Cancer

Durvalumab Combined With Surufatinib as Maintenance Therapy in Patients With Advanced Biliary Tract Cancer

Start date: February 15, 2024
Phase: Phase 1/Phase 2
Study type: Interventional

A Real-World Study of Durvalumab combined with Surufatinib as maintenance therapy in patients with advanced biliary tract cancer whose disease did not progress after completion of first-line Durvalumab combined with Gemcitabine+cisplatin treatment.

NCT ID: NCT06254742 Not yet recruiting - Clinical trials for Patients With Nonmyeloid Malignancies Receiving Antineoplastic Therapy Based on Chemotherapy Regimens at Moderate to High Febrile Neutropenia (FN) Risk

A Trial of HHPG-19K Injection and Auto-HHPG-19K Injection in Prevention of Chemotherapy-related Moderate to Severe Neutropenia of Patients With Nonmyeloid Malignancies

Start date: February 2024
Phase: Phase 3
Study type: Interventional

The study is being conducted to evaluate the preference, and safety of HHPG-19K Injection and Auto-HHPG-19K Injection in Prevention of chemotherapy-related moderate to severe neutropenia of Patients with nonmyeloid malignancies.