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NCT ID: NCT05051930 Not yet recruiting - Clinical trials for Chronic Obstructive Pulmonary Disease

A Clinical Trial of TQC3721 Suspension for Inhalation

Start date: September 2021
Phase: Phase 1
Study type: Interventional

To evaluate the safety, tolerability and pharmacokinetic characteristics of TQC3721 suspension for inhalation in single/multiple administration(s) in healthy subjects; to evaluate the safety,tolerability and efficacy TQC3721 suspension for inhalation in multiple administrations in patients with Chronic Obstructive Pulmonary Disease(COPD)and asthma.

NCT ID: NCT05051891 Not yet recruiting - Clinical trials for Treatment-na?ve Mantle Cell Lymphoma

A Randomized, Open-label, Multi-center, Phase III Study of Orelabrutinib in Combination With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) vs. R-CHOP Alone in Patients With Treatment-naїve Mantle Cell Lymphoma

Start date: September 2021
Phase: Phase 3
Study type: Interventional

To evaluate the efficacy of orelabrutinib combined with R-CHOP vs. R-CHOP alone in the treatment of treatment-naїve mantle cell lymphoma.

NCT ID: NCT05051865 Not yet recruiting - Melanoma Clinical Trials

To Explore the Efficacy and Safety of Camrelizumab Combined With SHR1020 in the Treatment of Advanced Melanoma

Start date: September 30, 2021
Phase: Phase 2
Study type: Interventional

This study is being conducted to explore the efficacy and safety of camrelizumab combined with SHR1020 in the treatment of advanced melanoma.

NCT ID: NCT05051852 Recruiting - HPV Infection Clinical Trials

A Multicenter Cohort Study of HPV Viral Load in Predicting the Prognosis of LSIL

Start date: September 1, 2021
Phase:
Study type: Observational [Patient Registry]

Human papillomavirus (HPV) infection has become one of the most important health problems faced by women all over the world. A large number of studies have shown that women's cervical, vaginal and perianal precancerous lesions, related cancers, condyloma acuminatum and other sexually transmitted diseases (STD) are closely related to HPV infection. Among them, the persistent infection of high-risk human papillomavirus (HR-HPV) is closely related to the occurrence of invasive cervical cancer. Previous studies have shown that there are significant differences in the effects of multiple HPV infection and persistent infection of different types (such as type-16, -18, -39 and -52) on different levels of cervical lesions, and there is a certain correlation between HPV load in the process of persistent infection and the degree of cervical lesions. In addition, other studies have shown that HPV-16 viral load has certain clinical significance in predicting Cin2 / CIN3 high-grade cervical lesions, and HPV viral load level is significantly different in cervical low-grade squamous intraepithelial lesion (LSIL) and cervical high-grade squamous intraepithelial lesion (HSIL). The above biological changes such as HPV infection type, quantity and proportion can promote the occurrence and development of cervical precancerous lesions and related cancers to varying degrees. It can be seen that the study of the relationship between HPV viral load and cervical lesions is of great significance for clinical disease development prediction and cervical cancer screening.

NCT ID: NCT05051826 Completed - Resistance, APC Clinical Trials

Effect of Resistance Training in Water Combined With Land on Starting and Turning ,12-weeks Resistance Training

Start date: February 9, 2021
Phase: N/A
Study type: Interventional

Resistance training has been widely used in various sports and is a common practice aimed at improving competition performance, especially in swimming. Swimming performance is highly dependent on muscle strength, especially short distances. Water or land resistance training can improve the swimming performance, especially the swimming performance of 50 meters and 100 meters. Both type of training has their own strength and weakness. Hence, combining both methods strength may enhance swimmer performance. In addition, competitive swimming consists of different stages, namely start, clean swim, turn and finish. However, there is no literature on the influence of resistance training on starting and turning.

NCT ID: NCT05051761 Not yet recruiting - Alopecia Areata Clinical Trials

Study to Evaluate Safety and Efficacy of Jaktinib in Adults With Alopecia Areata

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Start date: October 2021
Phase: Phase 3
Study type: Interventional

This is a multi-center Phase 3 study to evaluate the safety and effectiveness of an investigational study drug (called Jaktinib) in adults (≥18 years and <65 years) who have 50% or greater scalp hair loss. The study is placebo-controlled, meaning that some patients entering the study will not receive active study drug but will receive tablets with no active ingredients (a placebo). It is double-blinded, meaning that the Sponsor, the study doctors, the staff, and the patients will not know whether a patient is on active study drug (or the dose) or placebo.

NCT ID: NCT05051280 Recruiting - Clinical trials for Cardiovascular Diseases

Left Atrial Appendage Occlusion Under Cone-beam Computed Tomography Fusion Image Guidance

Start date: August 1, 2020
Phase: N/A
Study type: Interventional

Left atrial appendage occlusion is being widely recommended as a treatment strategy for patients with nonvalvular AF to prevent stroke, especially those who cannot tolerate long-term oral anticoagulation or have other reasons for nonpharmacologic therapy. Currently, there are a number of guidance for left atrial appendage occlusion, such as transesophageal echocardiography, intracardiac echocardiogram, fluoroscopy, computed tomographic/computed tomographic angiography and so on. Procedures such as atrial septal puncture, device size selection and operational view are guided by different methods in various centers. Our center has developed a new approach to guidance: Cone-beam CT and cardiac computed tomographic angiography were combined by three-dimensional - three-dimensional image fusion in guiding left atrial appendage occlusion.

NCT ID: NCT05051241 Not yet recruiting - Clinical trials for Advanced Solid Tumor

A Study of GFH018 in Patients With Advanced Solid Tumors

Start date: September 2021
Phase: Phase 1
Study type: Interventional

This is the first in human study of GFH018 comprised of a dose escalation part and a dose expansion part in subjects with advanced solid tumors after single/multiple administration. The study is designed to explore the safety/tolerability, pharmacokinetics, and MTD of GFH018 and to define a RP2D of GFH018.

NCT ID: NCT05051215 Recruiting - Microbiota Clinical Trials

Gut Microbiota and Nonpuerperal Mastitis

Start date: August 15, 2021
Phase:
Study type: Observational

Nonpuerperal mastitis (NPM), mainly including Plasma cell mastitis (PCM) and Granulomatous mastitis (GM), which clinical presentation is an accessible and painful breast mass accompanied by skin redness and swelling, nipple retraction and fistula formation . Much progress has been made in exploring the etiology and pathogenesis of NPM, while the exact etiology remains unknown, NPM is thought to arise from interactions between genetic susceptibility factors, epigenetic effects, and various environmental factors. While microbiota as an environment factor to some inflammatory and autoimmune diseases accept widespread attention, if gut microbiota also as a risk factor for NPM, it is worthy to be considered.

NCT ID: NCT05050877 Completed - Clinical trials for Coronary Artery Disease

Risk Factors and Prognosis of Adverse Cardiovascular and Kidney Events After Coronary Intervention II

Start date: June 1, 2000
Phase:
Study type: Observational

As a multi-center, retrospective observation study in southern China, this study included the main study population of patients who underwent coronary angiography at 5 hospitals from Guangzhou, Shenzhen, Yangjiang, Maoming and Longyan from January 2000 to Decemeber 2020. The hospitalization information was collected in the form of direct derivation of the case, and cardiac and renal adverse events were collected through outpatient system. Data on all-cause death were obtained from the Guangdong Provincial Public Security and matched to the electronic Clinical Management System of the Guangdong Provincial People's Hospital records.