Cardiac CT Angiography in Patients With Acute Ischemic Stroke

Coronary Artery Disease Clinical Trial

— ACUTE  

Official title:

Assessment of Cardiac CT Angiography in Patients Undergoing Thrombectomy for Ischemic Stroke

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06176872
• Other study ID #: 2022-100951-BO-ff
• Status: Not yet recruiting
• Start date: January 1, 2024
• Est. completion date: January 1, 2027

Study information

• Verified date: December 2023
• Source: Universitätsklinikum Hamburg-Eppendorf
• Contact: Jennifer Erley, MD
• Phone: +4915157487213
• Email: j.erley[@]uke.de
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Mortality rates after acute ischemic stroke remain high despite continuously improving treatment. In this context, it is important to note that a relevant portion of acute ischemic stroke patients die from adverse cardiovascular events, such as myocardial infarction, rather than from complications associated with the stroke itself. A possible reason might be that this patient group often suffers from at least moderate asymptomatic coronary artery disease. This study seeks to integrate cardiac computed tomography angiography into the standard-of-care diagnostic protocol of acute ischemic stroke. The aim of this prospective mono-centric trial is to enable accurate diagnosis of therapy-relevant coronary artery disease, other concomitant cardiac findings and cardiac causes of acute ischemic stroke, without delaying stroke therapy. In the long-run, the goal is to investigate whether cardiac computed tomography angiography and the resulting therapeutic measures (interventions or medications added) can improve functional outcome and rate of adverse cardiac complications in patients with acute ischemic stroke compared to a retrospective matched-cohort of patients without cardiac CT imaging.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 165
• Est. completion date: January 1, 2027
• Est. primary completion date: January 1, 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 40 Years and older

Eligibility

Inclusion Criteria:

• Patients aged 40 years or above, presenting at the Emergency Department of the University Medical Center Hamburg-Eppendorf with a suspected acute ischemic stroke and a relevant neurological deficit (NIHSS score > 4).

Exclusion Criteria:

• A causal differential diagnosis for the acute stroke syndrome with absent intracranial vessel occlusion.

• No correlation for the patients' symptoms in the cranial CTA (no vessel obstruction).

Related Conditions & MeSH terms

• Acute Ischemic Stroke
• Cerebral Infarction
• Coronary Artery Disease
• Ischemia
• Ischemic Stroke
• Stroke

Intervention

Diagnostic Test:
• Cardiac Computed Tomography Angiography
Non-invasive imaging of the heart, the greater vessels and the coronary arteries using computed tomography.

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Universitätsklinikum Hamburg-Eppendorf	Siemens Healthcare Diagnostics Inc

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Diagnosis of therapy-relevant CAD and concomitant cardiac findings resulting in new therapeutic measurements.	Number of (newly) prescribed medications (e.g., anticoagulants), cardiac diagnostics/interventions/planned interventions, clinical status (NIHSS, mRs).	1 day at hospital discharge
Secondary	The rate of adverse cardiovascular events (MACE).	rate of major adverse cardiovascular events (MACE).	90 and 365 days