The Effect of the 3/7 vs 3X9 Method in Resistance Training on Metabolic Stress in Cardiac Rehabilitation

Coronary Artery Disease Clinical Trial

Official title:

Acute Effects of the 3/7 Method and 3X9 Method in Resistance Training on Testosterone, Glucocorticoid Cortisol, Growth Hormone and Lactate in Heart Failure and Coronary Artery Disease During Cardiac Rehabilitation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05391620
• Other study ID #: 2020276
• Status: Completed
• Phase: N/A
• Start date: February 22, 2022
• Est. completion date: October 25, 2022

Study information

• Verified date: February 2024
• Source: Université Libre de Bruxelles
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The study proposes to measure the effect of resitance training (RT) (3/7 method) on biological markers of muscle hypertrophy in a cardiac population.

3/7 method consisting of five sets of an increasing number of repetitions (3 to 7) during successive sets and brief inter-set intervals (15 s). This method is compare to 3X9 method, 3 series of 9 repetitions with inter-set (1min).The training exercise consisted of contraction on machine (leg press, triceps press, leg curl, traction, leg extension) with load of ~ 70% of one repetition maximal (1RM).

Before these trainings all subject perform HIIT on bicycles (2 min high intensity (80% Wmax) and 2 min low intensity (50% Wmax) during 30 minutes.

The investigators collect blood sample before exercice, after HIIT and after RT.

It is randomized cross-over study.

Description:

The subjects come on two different days minimum 2 days and maximum 10 days between the two tests. They were instructed to avoid exercise the day before they participated in the study.

The investigators collect blood 2 minutes after endurance training (HIIT) and 2 min after RT training.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 25
• Est. completion date: October 25, 2022
• Est. primary completion date: June 10, 2022
• Accepts healthy volunteers: No
• Gender: Male
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Clinical Coronary artery diseases

• Heart failure with reduced ejection fraction

Exclusion Criteria:

• angina

• acutely decompensated heart failure

• electrocardiographic evidence of ischemia

• significant valvular disease

• orthopedic/neurologic disorders that limited exercise

Related Conditions & MeSH terms

• Coronary Artery Disease
• Coronary Disease
• Heart Failure
• Myocardial Ischemia
• Resistance Training

Intervention

Other:
• Cardiac rehabilitation with 3/7 method
HIIT ( 2 min 80% wmax: 2 min 50% wmax) during 30 minutes 3/7 method 3 rep (15 sec of rest), 4 rep (15 sec), 5 rep (15 sec), 6 rep (15 sec), 7 rep. (total volume : 25 repetitions) at 70 of 1 repetition Leg press, Dips Press, Leg curl, Traction and Leg extension. 1 minute between each machine is planned.
• Cardiac rehabilitation with 3X9 method
HIIT ( 2 min 80% wmax: 2 min 50% wmax) during 30 minutes 3X9 method 9 rep 1 minute of rest, 9 rep (1 min) and 9 rep (total volume : 27 repetitions) at 70 of 1 repetition Leg press, Dips Press, Leg curl, Traction and Leg extension. 1 minute between each machine is planned

Locations

Country	Name	City	State
Belgium	Erasme Hospital	Brussels

Sponsors (1)

Lead Sponsor	Collaborator
Université Libre de Bruxelles

Country where clinical trial is conducted

Belgium, 

References & Publications (1)

Mang ZA, Realzola RA, Ducharme J, Bellissimo GF, Beam JR, Mermier C, de Castro Magalhaes F, Kravitz L, Amorim FT. The effect of repetition tempo on cardiovascular and metabolic stress when time under tension is matched during lower body exercise. Eur J Appl Physiol. 2022 Jun;122(6):1485-1495. doi: 10.1007/s00421-022-04941-3. Epub 2022 Apr 8. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in Lactate	mmol/l	within 2 minutes after TR training session on day 1
Primary	change in Testosterone	nmol/l	within 2 minutes after TR training session on day 1
Primary	change Glucocorticoid Cortisol	nmol/l	within 2 minutes after TR training session on day 1
Primary	change in Growth Hormone	ng/ml	within 2 minutes after TR training session on day 1
Primary	change in ph	venoust	within 2 minutes after TR training session on day 1
Primary	change PCO2 venoust	mm Hg	within 2 minutes after TR training session on day 1
Secondary	Borg scale	Borg Rating of Perceived Exertion - Borg modified (0 = no exertion at all -10 maximal exertion)	within 4 minutes after TR training session on day 1
Secondary	Pleasure of the session scale	0 = worse 10 = better	within 4 minutes after TR training session on day 1