Atrial Fibrillation and Non-obstructive Coronary Lesions

Coronary Artery Disease Clinical Trial

— AF-CAD  

Official title:

Is Atrial Fibrillation is Associated With Non-significant Coronary Angiography Findings?

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04537507
• Other study ID #: UMB-KKI-102
• Status: Completed
• Start date: January 2010
• Est. completion date: January 2022

Study information

• Verified date: September 2021
• Source: Medical University of Bialystok
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Atrial fibrillation (AF) is the most common cardiac arrhythmia associated with excessive risk of ischemic stroke and heart failure as well as reduced life expectancy. On the other hand, chronic coronary syndromes (CCS) remains the main cause of morbidity and mortality in an aging population. Both disease entities share common risk factors such as hypertension, diabetes and obesity The purpose of the study is to investigate the hypothesis indicating lack of significant coronary lesions in AF vs. sinus rhythm (SR) patients.

Description:

Atrial fibrillation (AF) and chronic coronary syndromes (CCS) share common risk factors and both disease entities frequently co-exist. Additionally, AF symptoms may mimic CCS. Objectives: To investigate the hypothesis indicating lack of significant coronary lesions in AF vs. sinus rhythm (SR) patients.

The prevalence of CCS in patients with AF varies from 17% to 47% whereas AF in patients with CCS is much less common, ranging from 0.2% to 5.Patients with AF more often have concomitant CCS as compared with sinus rhythm controls. Additionally, AF is more frequently present in patients with either peripheral- or cerebrovascular artery disease than in non-atherosclerotic individuals We conducted a multi-center retrospective study including consecutive patients referred for elective coronary angiography.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 8000
• Est. completion date: January 2022
• Est. primary completion date: December 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Coronary angiography

Exclusion Criteria:

• We excluded patients with acute coronary syndromes (ACS), Tako-tsubo cardiomiopathy and history of ischemic heart disease, as well as those referred for coronary angiography before heart valve surgery. Prior cardiosurgical valve replacement was also the exclusion criterion.

Related Conditions & MeSH terms

• Atrial Fibrillation
• Chronic Kidney Diseases
• Coronary Artery Disease
• Coronary Disease
• Fibrillation, Atrial
• Kidney Diseases
• Myocardial Ischemia
• Renal Insufficiency, Chronic

Intervention

Procedure:
• Coronary angiography

Locations

Country	Name	City	State
Poland	Department of Cardiology, Medical University of Bialystok, Bialystok, Poland	Bialystok
Poland	Medical Univeristy of Bialystok	Bialystok
Poland	Department of Cardiology and Internal Medicine, Medical University of Gdansk, Gdynia, Poland	Gdansk
Russian Federation	Department of Internal diseases, I.M.Sechenov First Moscow State Medical University, Moscow, Russian Federation	Moscow
United Kingdom	iverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom	Liverpool

Sponsors (4)

Lead Sponsor	Collaborator
Medical University of Bialystok	I.M. Sechenov First Moscow State Medical University, Liverpool Heart and Chest Hospital NHS Foundation Trust, Medical University of Gdansk

Countries where clinical trial is conducted

Poland,  Russian Federation,  United Kingdom, 

References & Publications (2)

Rogalska E, Kuzma L, Wojszel ZB, Kurasz A, Napalkov D, Sokolova A, Tomaszuk-Kazberuk A. Atrial fibrillation is a predictor of nonobstructive coronary artery disease in elective angiography in old age: a cross-sectional study in Poland and Russia. Aging Cl — View Citation

Tomaszuk-Kazberuk A, Kozinski M, Kuzma L, Bujno E, Lopatowska P, Rogalska E, Dobrzycki S, Sobkowicz B, Lip GYH. Atrial fibrillation is more frequently associated with nonobstructive coronary lesions: the Bialystok Coronary Project. Pol Arch Intern Med. 20 — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Coronary artery disease	Number of Participants with significant findings on coronary angiography	Through study completion, an average of 8 years