Coronary Artery Disease Clinical Trial
Official title:
Neutrophil Gelatinase-associated Disease: a Potential Biomarker of the Severity of Coronary Artery Disease
Serum NGAL has been described as a biomarker of neutrophil activation and an inflammatory marker which correlates to obesity and its metabolic complications. Since neutrophil activation has been implicated in the pathogenesis of coronary artery disease, the investigators hypothesized that serum NGAL levels would be higher in patients with CAD and that serum concentration would correlate with the extent of CAD as documented by coronary angiography, serving as a potential biomarker of the severity of CAD.
Inflammation is considered to play a major role in coronary artery disease (CAD) which
accounts for high morbidity and mortality rates in the western world. Several lines of
evidence support a role for neutrophils in the development of atherosclerosis and its
progression.
Neutrophil gelatinase-associated lipocalin (NGAL), also known as Lipocalin-2, is a 25-kDa
secretory glycoprotein that was originally identified in mouse kidney cells and human
neutrophil granules. This protein has been used as a marker of neutrophil activation in
several studies, while recently it was found to be an inflammatory marker closely related to
obesity and its metabolic complications.
Recently, lactoferrin, a protein which co-localizes with NGAL in the specific granules of
human neutrophils has been proposed as a more dynamic marker of neutrophil activation
compared to the widely used myeloperoxidase in patients with CAD.
In line with the accumulating evidence, this study is designed to investigate the
relationship between serum NGAL concentration and the presence or the severity of coronary
artery disease according to coronary angiography.
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Observational Model: Case Control, Time Perspective: Prospective
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