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Colonoscopy clinical trials

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NCT ID: NCT03925506 Completed - Colonoscopy Clinical Trials

Predictive Factors of Inadequate Bowel Preparation in Inpatients

QIPS
Start date: February 1, 2019
Phase:
Study type: Observational

About 50-70% only of inpatients who undergo colonoscopy have an adequate bowel cleansing, which is far below the recommended threshold of 90%. Variables associated to inadequate colon preparation have not been assessed yet. Identifying such variables would allow to augment the diagnostic yield of colonoscopy, and also to reduce costs related to the need to repeat colonoscopy. Aim of the present study is to find variables independently associated to an inadequate bowel cleansing and to subsequently build and validate a predictive model, which could prove useful in clinical practice to identify hard-to-prepare inpatients. Secondary endpoints are (i) to assess the proportion of patients with inadequate colon cleansing, (ii) to run a cost-effectiveness analysis between patients with adequate cleansing and patients who need to repeat colonoscopy. Patients undergoing urgent colonoscopy, and patients who take the preparation at home will be excluded.

NCT ID: NCT03892928 Completed - Colonoscopy Clinical Trials

Safety and Efficacy of Dexmedetomidine in Painless Colonoscopy

Start date: December 1, 2019
Phase: N/A
Study type: Interventional

104 patients who undergo painless colonoscopy from Decemenber 1,2019 to June 30,2022 will be randomized to two groups: propofol group and dexmedetomidine group. In the dexmedetomidine group,dexmedetomidine was infusion intravenously with a loading dose of 0.5 μg kg-1 for 10 min, then infusion at 0.3 μg kg-1 h-1 according to the ideal body weight of the patient until the end of colonoscopy. In the propofol group, Propofol was administrated 1 mg kg-1 intravenously, then titrated given by 0.5 mg kg-1 during the whole process.

NCT ID: NCT03813303 Completed - Anesthesia Clinical Trials

Comparison of Post Anesthetic Recovery Time in Sedated Patients for Colonoscopy

CPART
Start date: March 20, 2018
Phase: Phase 4
Study type: Interventional

Colonoscopy is an important diagnostic and therapeutic tool in colon disorders. Different drugs and levels of sedation can be used in its accomplishment. There is no consensus on which is the ideal. The aim of this study was to compare the post anesthetic recovery time between patients deeply sedated with midazolam and propofol or fentanyl and propofol. 50 American Society of Anesthesiologist physical state (ASA) I and II candidates elective colonoscopy at Luxembourg Hospital were divided into two groups A) midazolam and propofol or B) fentanyl and propofol. Time of examination, post anesthetic recovery and discharge at home, intercurrence and propofol consumption were compared.

NCT ID: NCT03807089 Completed - Colonoscopy Clinical Trials

Adenoma Detection Rate With a New Pediatric Colonoscope With a Short Turn Radius (Pentax Retroview) Compared With a Standard Pentax Pediatric Colonoscope

Start date: July 1, 2014
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether the new colonoscope that provides both a traditional and a retrograde view (bending 180 degrees to look behind itself) of the colon can detect more polyps than a standard colonoscope that only provides a forward-facing view. The investigators wish to effectively demonstrate the utility of the new colonoscope (Pentax Retroview Colonoscope) as the objective of this study is to determine polyp and adenoma detection rates in human subjects undergoing colonoscopy for polyp surveillance.

NCT ID: NCT03796169 Completed - Colonoscopy Clinical Trials

Effect of Intervention for Colonoscopy Quality is Associated With the Personal Characteristics

Start date: December 12, 2018
Phase: N/A
Study type: Interventional

This study aims to investigate whether the personal characteristics of the endoscopist is associated with effect of interventions for colonoscopy quality improvement. This is a prospective, 9-month, multicenter, single-blind study. Baseline quality indicators including adenoma detection rate, polyp detection rate, withdrawal time and adenomas per colonoscopy of each endoscopist were measured in the health promotion centers of academic hospitals for 3 months. Follow-up measurements of quality indicators were repeated every 3 months after each interventions (personal notification of quality indicators, open notification of quality indicators, and colonoscopy quality education by a GI faculty. At the end of the study, personal characteristics of each endoscopist was evaluated using fear of negative evaluation scale, cognitive flexibility inventory, and almost perfect scale.

NCT ID: NCT03775811 Completed - Colonoscopy Clinical Trials

In Vivo Computer-aided Prediction of Polyp Histology on White Light Colonoscopy

Start date: January 1, 2019
Phase:
Study type: Observational

Our group, prior to the present study, developed a handcrafted predictive model based on the extraction of surface patterns (textons) with a diagnostic accuracy of over 90%24. This method was validated in a small dataset containing only high-quality images. Artificial intelligence is expected to improve the accuracy of colorectal polyp optical diagnosis. We propose a hybrid approach combining a Deep learning (DL) system with polyp features indicated by clinicians (HybridAI). A pilot in vivo experiment will carried out.

NCT ID: NCT03773042 Completed - Colonoscopy Clinical Trials

A Study Evaluating Tolerability, Efficacy, and Safety of HSK3486 Injectable Emulsion in Patients

Start date: December 2016
Phase: Phase 2
Study type: Interventional

A double-blind, randomized, active controlled, multi-center, parallel group study comparing HSK3486 with Propofol, in patients undergoing a colonoscopy.

NCT ID: NCT03763266 Completed - Clinical trials for Inflammatory Bowel Diseases

Low Residue Diet During 3 Days vs 1 Day Prior Colonoscopy

Start date: December 6, 2018
Phase: N/A
Study type: Interventional

Colonoscopy is the gold-standard for the evaluation of the colorectal mucosa. Colonoscopy quality indicators are the adenoma detection rate, the rate of cecal intubation and the bowel preparation. The role of diet in preparing for colonoscopy is not fully established. Currently there is not enough evidence available to choice between 3 days of low residue diet versus 1 day. The research hypothesis is that the low residue diet offers a non-inferior bowel preparation and an improved tolerance.

NCT ID: NCT03760133 Completed - Colonoscopy Clinical Trials

The Change of Gut Microbiota After Bowel Preparation and the Effect of Probiotics

Start date: December 1, 2018
Phase: Phase 2
Study type: Interventional

The purpose of this study is to investigate the relationship between the change of intestinal bacterial flora and the recovery, and the incidence of symptoms such as abdominal discomfort after colonoscopy. And the investigators will also analyze the effects of probiotics on the degree of change, recovery, and symptom development in intestinal flora.

NCT ID: NCT03758872 Completed - Colonoscopy Clinical Trials

CUFF-assisted Colonoscopy vs Standard Colonoscopy

CUFF-TROCADERO
Start date: October 25, 2018
Phase:
Study type: Observational

The goal of this study is to evaluate the interest of second-generation Endocuff Vision (ECV) to improve Adenoma detection rate and / or Polyp detection rate in routine colonoscopy. This is a prospective comparative cohort, on 1034 patients, 517 patients with ECV in prospective group and 517 without ECV in retrospective group