Cardiovascular Diseases Clinical Trial
To test the hypothesis that implantable cardioverter defibrillator (ICD) therapy will improve survival in coronary heart disease patients at high risk of death, especially arrhythmic death.
Status | Completed |
Enrollment | 0 |
Est. completion date | December 1998 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 80 Years |
Eligibility | Men and women, up to age 80, with a left ventricular ejection fraction less than .36 and an abnormal signal averaged electrocardiogram. |
Allocation: Randomized, Primary Purpose: Treatment
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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National Heart, Lung, and Blood Institute (NHLBI) |
Argenziano M, Spotnitz HM, Whang W, Bigger JT Jr, Parides M, Rose EA. Risk stratification for coronary bypass surgery in patients with left ventricular dysfunction: analysis of the coronary artery bypass grafting patch trial database. Circulation. 1999 Nov 9;100(19 Suppl):II119-24. — View Citation
Bigger JT Jr, Parides MK, Rolnitzky LM, Meier P, Levin B, Egan DA. Changes in sample size and length of follow-up to maintain power in the coronary artery bypass graft (CABG) patch trial. Control Clin Trials. 1998 Feb;19(1):1-14. — View Citation
Bigger JT Jr, Whang W, Rottman JN, Kleiger RE, Gottlieb CD, Namerow PB, Steinman RC, Estes NA 3rd. Mechanisms of death in the CABG Patch trial: a randomized trial of implantable cardiac defibrillator prophylaxis in patients at high risk of death after coronary artery bypass graft surgery. Circulation. 1999 Mar 23;99(11):1416-21. — View Citation
Bigger JT Jr. Prophylactic use of implanted cardiac defibrillators in patients at high risk for ventricular arrhythmias after coronary-artery bypass graft surgery. Coronary Artery Bypass Graft (CABG) Patch Trial Investigators. N Engl J Med. 1997 Nov 27;337(22):1569-75. — View Citation
Bigger JT.The CABG Patch Trial. In: Santini M, ed. Progress in Clinical Pacing,1994. Armonk, NY: Futura Media Services, Inc., 1995:809-827.
Cook JR, Flack JE, Gregory CA, Deaton DW, Rousou JA, Engelman RM. Influence of the preoperative signal-averaged electrocardiogram on left ventricular function after coronary artery bypass graft surgery in patients with left ventricular dysfunction. The CABG Patch Trial. Am J Cardiol. 1998 Aug 1;82(3):285-9. — View Citation
Curtis AB, Bigger JT Jr, DiMarco JP, Anderson JL. Epicardial cardioverter-defibrillators do not cause postoperative arrhythmias. The CABG Patch Trial Investigators. Coronary Artery Bypass Graft. Am J Cardiol. 1998 Nov 1;82(9):1114-7, A9. — View Citation
Curtis AB, Cannom DS, Bigger JT Jr, DiMarco JP, Estes NA 3rd, Steinman RC, Parides MK. Baseline characteristics of patients in the coronary artery bypass graft (CABG) Patch Trial. Am Heart J. 1997 Nov;134(5 Pt 1):787-98. — View Citation
Flack JE 3rd, Cook JR, May SJ, Lemeshow S, Engelman RM, Rousou JA, Deaton DW. Does cardioplegia type affect outcome and survival in patients with advanced left ventricular dysfunction? Results from the CABG Patch Trial. Circulation. 2000 Nov 7;102(19 Suppl 3):III84-9. — View Citation
Kron IL, Cope JT, Baker LD Jr, Spotnitz HM. The risks of reoperative coronary artery bypass in chronic ischemic cardiomyopathy: results of the CABG Patch Trial. Circulation. 1997 Nov 4;96(9 Suppl):II-21-5. — View Citation
Namerow PB, Firth BR, Heywood GM, Windle JR, Parides MK. Quality-of-life six months after CABG surgery in patients randomized to ICD versus no ICD therapy: findings from the CABG Patch Trial. Pacing Clin Electrophysiol. 1999 Sep;22(9):1305-13. — View Citation
Olshansky B, Telfer EA, Curtis AB, Bigger JT Jr. Predictive value of preoperative left ventricular ejection fraction and functional class for mortality and morbidity after high-risk coronary artery bypass grafting. Am J Cardiol. 2000 Jun 15;85(12):1489-91; A7. — View Citation
Spotnitz HM, Herre JM, Baker LD Jr, Fitzgerald DM, Kron IL, Bigger JT Jr. Surgical aspects of a randomized trial of defibrillator implantation during coronary artery bypass surgery. The CABG Patch Trial. Circulation. 1996 Nov 1;94(9 Suppl):II248-53. — View Citation
Spotnitz HM, Herre JM, Raza ST, Hammon JW Jr, Baker LD Jr, Fitzgerald DM, Kron IL, Bigger JT Jr. Effect of implantable cardioverter-defibrillator implantation on surgical morbidity in the CABG Patch Trial. Surgical Investigators of the Coronary Artery Bypass Graft Patch Trial. Circulation. 1998 Nov 10;98(19 Suppl):II77-80. — View Citation
The Coronary Artery Bypass Graft (CABG) Patch Trial. The CABG Patch Trial Investigators and Coordinators. Prog Cardiovasc Dis. 1993 Sep-Oct;36(2):97-114. — View Citation
Whang W, Bigger JT Jr. Diabetes and outcomes of coronary artery bypass graft surgery in patients with severe left ventricular dysfunction: results from The CABG Patch Trial database. The CABG Patch Trial Investigators and Coordinators. J Am Coll Cardiol. 2000 Oct;36(4):1166-72. Erratum in: J Am Coll Cardiol 2001 Jun 1;37(7):2012. — View Citation
* Note: There are 16 references in all — Click here to view all references
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