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Cardiac Disease clinical trials

View clinical trials related to Cardiac Disease.

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NCT ID: NCT01616017 Completed - Cardiac Disease Clinical Trials

Comparison of Cardiac Output Measured by Ultrasound Dilution Method and Pulmonary Artery Thermodilution Technique

Start date: May 2012
Phase: N/A
Study type: Observational

Cardiac output (CO) is an important hemodynamic variable in the management of critically ill patients. The pulmonary artery catheter (PAC) requires invasive techniques with potential complications and there is increasing interest in less invasive methods of measuring CO. This study is designed to compare CO values from PAC thermodilution (COTD) and ultrasound dilution (COUD).

NCT ID: NCT01609686 Completed - Cardiac Disease Clinical Trials

Pharmacokinetics of Tranexamic Acid in Patients With Varying Renal Function Undergoing Cardiac Surgery With the Use of Cardiopulmonary Bypass

Start date: January 2012
Phase: N/A
Study type: Observational

Cardiopulmonary bypass surgery is associated with extensive blood loss in upto 20% of patients. Tranexamic acid (TXA) is a routinely administered antifibrinolytic agent that reduces blood loss and blood transfusion requirement. However, standard dosing of TXA in patients suffering from renal dysfunction and undergoing cardiopulmonary bypass surgery may lead to higher blood concentration of TXA when compared to the patients with normal renal function. Solid phase microextraction (SPME) is a fast and simple method to measure TXA levels. This prospective study on cadiac surgical patients undergoing cardiopulmonary bypass aims to study the pharmacokinetics of TXA in patients with renal dysfunction. Two patient groups will be studied who will receive either TXA 50mg/kg bolus or BART regimen (30 mg/kg, 16 mg/kg/h + 2 mg/kg pump prime) depending on the type of cardiac surgical procedure and bleeding risk. Hypothesis: Standard dosing of TXA used in cardiac surgery result in higher blood concentration of TXA in patients with renal dysfunction when compared to patients with normal renal function.

NCT ID: NCT01600482 Completed - Clinical trials for Coronary Artery Disease

Clinical Investigation for Safety and Efficacy Study of CELT ACD Arterial Closure Device

Start date: May 2012
Phase: N/A
Study type: Interventional

The objective of the CELT ACD® Vascular Closure Device study is to evaluate the safety and effectiveness of the CELT ACD® device to achieve hemostasis of the common femoral artery access site in patients on anticoagulation who are undergoing a percutaneous coronary intervention (PCI) procedure using either a 6F or 7F procedural sheath.

NCT ID: NCT01502332 Recruiting - Cardiac Disease Clinical Trials

Intensive Alveolar Recruitment Protocol After Cardiac Surgery

Start date: December 2011
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate prospectively the impact of two protective mechanical ventilation strategies, both using low-tidal volume ventilation (6 mL/kg/ibw) after cardiac surgery. The study will select patients presenting signals of deficient gas exchange (PaO2/FIO2 < 250 at a PEEP of 5 cmH2O) in the immediate post-operative period. An aggressive alveolar recruitment protocol applying opening pressures of 45 cmH2O, followed by ventilation with PEEP = 13 cmH2O, will be compared to the standard alveolar recruitment protocol of the institution, where an opening pressure of 20 cmH2O in the airways is followed by ventilation with PEEP = 8 cmH2O. After a stabilizing period of four hours of controlled mechanical ventilation, the patients will follow the routine weaning protocol and physiotherapy protocol of the institution.

NCT ID: NCT01487941 Completed - Cardiac Disease Clinical Trials

Setrox JS Master Study

Start date: December 2011
Phase: N/A
Study type: Observational

The purpose of this study is the evaluation of safety and efficacy of the pacemaker lead "Setrox JS".

NCT ID: NCT01486836 Completed - Cardiac Disease Clinical Trials

Lumax DX / Linox DX Evaluation

Start date: November 2011
Phase: N/A
Study type: Observational

The objective of this study is to investigate the safety and efficacy of the Lumax DX / Linox DX system. No hypothesis has been defined.

NCT ID: NCT01466218 Completed - Clinical trials for Obstructive Sleep Apnea

World Trade Center (WTC) CHEST

Start date: November 2011
Phase: N/A
Study type: Observational

This project will evaluate the effects of World Trade Center (WTC) exposure in WTC responders 10-13 years following the events of 9/11. Prior studies have described persistent pulmonary function abnormalities in a significant portion of responders. The investigators study seeks to examine the relationship between pulmonary function abnormalities and other markers of chronic cardiopulmonary disease and further elucidate the pathophysiologic effects of exposure to inhaled particulate matter (PM) on 9/11. This study will provide critical information regarding risk of exposure to PM, risk factors for disease and potential for improvements in diagnosis and treatment.

NCT ID: NCT01461629 Completed - Heart Failure Clinical Trials

Self-management and Cognitive Function in Adults With Heart Failure

Heart ABC
Start date: June 2010
Phase: N/A
Study type: Observational

The purpose of this study is to assess the relationship between cognitive impairment, patient self-management, health, and health service use in adults with heart failure (NYHA Class 2 and 3). The research questions are: 1. How is cognitive impairment (memory, attention, global and executive function) related to various aspects of impaired self-management (knowledge of adherence, adherence to sodium restriction and medications, symptom monitoring of weight changes, and decision and action to seek care)? 2. How are these relationships altered when adjusting for medical, demographic, and psychosocial factors? 3. What are the relationships among degree of cognitive impairment, quality self-management, health status, and health service use?

NCT ID: NCT01460992 Completed - Cardiac Disease Clinical Trials

ProMRI AFFIRM Study of the EVIA/ENTOVIS Pacemaker With Safio S Pacemaker Leads

ProMRIAFFIRM
Start date: March 2012
Phase: N/A
Study type: Observational

This investigation is designed to demonstrate the clinical safety of the EVIA/ ENTOVIS pacemaker system when used under specific MRI conditions.

NCT ID: NCT01404767 Terminated - Hypertension Clinical Trials

Tight Hemodynamic Control in Patients Who Are Chronically on Metoprolol

Start date: April 2011
Phase: Phase 4
Study type: Interventional

This study proposes to assess the effect of the standard of care, which is continuation of the pre op beta blocker dose into the post operative period compared to the administration of esmolol titrated to a pre determined target HR. The primary outcome will compare postoperative plasma levels of metoprolol in 2 cohorts in a group who has been continued on metoprolol (administrated via a nasogastric tube in NPO patients) to a group who has been withdrawn from metoprolol but given an esmolol infusion titrated to HR. Secondary outcomes will compare a) the hemodynamic responses, documenting the incidence of unplanned hypotension and bradycardia and b) to compare the effects of Heart rate to the incidence of myocardial ischemia, arrhythmias, delirium and infarction.